Itih‐4, a serine protease inhibitor regulated in interleukin‐6–dependent liver formation: role in liver development and regeneration

Bhanumathy, Cunnigaiper D.; Tang, Yi; Monga, Satdarshan P.; Katuri, Varalakshmi; Cox, Jos A.; Mishra, Bibhuti; Mishra, Lopa

doi:10.1002/dvdy.1235

Cited by 50 publications

(42 citation statements)

References 59 publications

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“…We recently engineered a mouse in which the gene for IL-6 regulated protein, itih4, has been deleted (29). ITIH4 is a member of a liver-restricted serine protease inhibitor family, expressed in hepatoblasts, and is a biomarker of foregut cancers of uncertain function (30)(31)(32).…”

Section: Resultsmentioning

confidence: 99%

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling

Tang

Kitisin

Jogunoori

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

297

261

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Section: Resultsmentioning

confidence: 99%

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling

Tang

Kitisin

Jogunoori

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

297

261

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“…Inhibition of actin polymerization and phagocytosis has also been reported as a consequence of the action of the protein in polymorphonuclear cells (7). Additional functions involving roles in liver development and regeneration have recently been reported for ITIH4 (4). The facts that kallikrein acting upon PK-120 may release peptides with kinin activity (33) and that ITIH4 is an APP in different species open a new gate to the study of the complex process of inflammation and infection.…”

Section: Discussionmentioning

confidence: 98%

ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 4) Is a New Acute-Phase Protein Isolated from Cattle during Experimental Infection

et al. 2004

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We have isolated from calf serum a protein with an apparent M r of 120,000. The protein was detected by using antibodies against major acute-phase protein in pigs with acute inflammation. The amino acid sequence of an internal fragment revealed that this protein is the bovine counterpart of ITIH4, the heavy chain 4 of the inter-alpha-trypsin inhibitor family. The response of this protein in the sera was determined for animals during experimental bacterial and viral infections. In the bacterial model, animals were inoculated with a mixture of Actinomyces pyogenes, Fusobacterium necrophorum, and Peptostreptococcus indolicus to induce an acute-phase reaction. All animals developed moderate to severe clinical mastitis and exhibited remarkable increases in ITIH4 concentration in serum (from 3 to 12 times the initial values, peaking at 48 to 72 h after infection) that correlated with the severity of the disease. Animals with experimental infections with bovine respiratory syncytial virus (BRSV) also showed increases in ITIH4 concentration (from two-to fivefold), which peaked at around 7 to 8 days after inoculation. Generally, no response was seen after a second infection of the same animals with the virus. Because of the significant induction of the protein in the animals in the mastitis and BRSV infection models, we can conclude that ITIH4 is a new positive acute-phase protein in cattle.The acute-phase response occurs in animals as a consequence of infection, inflammation, or trauma. It is a nonspecific response mediated by inflammation-related cytokines (mainly by interleukin-6 [IL-6], IL-1, and tumor necrosis factor alpha) and is characterized by several systemic reactions, including fever, catabolism of muscle protein, alterations in sleep and appetite patterns, and changes in the concentrations of a group of serum proteins called acute-phase proteins (APP) (3,22,27,40).APP have been studied extensively in humans and in many animal species, mostly rats (38), though the panel of these proteins is probably not complete. The APP response differs among species. For domestic animals, the studies on APP are relatively recent (reviewed in reference 18). For cattle, several APP, including serum amyloid A, haptoglobin, alpha-1-acid glycoprotein, and alpha-1-proteinase inhibitor (alpha-1-antitrypsin), have been shown to increase in different inflammatory processes, in both in vivo (9,14,18,20,23,25,32) and in vitro models (2, 31). The course of infection in human patients is monitored by the determination of APP in blood samples (43), and a similar clinical use has been proposed for veterinary medicine (15,18,26) as well as for monitoring the health status of animals during farm production and at slaughter (42).In previous works from our laboratory, a new 120-kDa plasma glycoprotein, designated major acute-phase protein or pig MAP, was described as an APP occurring in pigs with turpentine-induced inflammation (16,29). This protein, which is also called porcine inter-alpha-trypsin inhibitor human-related protein (pig IHRP) (...

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“…13) Pig MAP is considered to be the IHRP counterpart of an acute phase protein, based on Northern blot analysis of the mouse IHRP expression during the inflammatory reaction induced by turpentine or LPS. Mouse IHRP mRNA expression peaked and then gradually fell to control levels 12 hr after the administration of turpentine or LPS (Figs.…”

Section: Discussionmentioning

confidence: 99%

Mouse Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein is an Acute Phase Protein Induced by Inflammation

Sano

Tobe

Saguchi

et al. 2006

JOURNAL OF HEALTH SCIENCE

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The mouse counterpart of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), inter-alpha-trypsin inhibitor family heavy chain-related protein, was partially purified from mouse serum through Western blot analysis using anti-human IHRP antibody. The amino-terminal amino acid sequence was then determined, and the cDNA clone encoding mouse IHRP was isolated and characterized. The mouse IHRP amino-terminal amino acid sequence matched the predicted sequence from the cDNA, and has high homology compared with human and pig IHRP. Furthermore, the whole mouse IHRP amino acid sequence predicted from the cDNA nucleotide sequence showed reasonable homology to that of both human and pig IHRP. Mouse IHRP expression was induced by treatment with typical inflammation-inducing compounds, such as turpentine and lipopolysaccharide.

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Itih‐4, a serine protease inhibitor regulated in interleukin‐6–dependent liver formation: role in liver development and regeneration

Cited by 50 publications

References 59 publications

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling

ITIH4 (Inter-Alpha-Trypsin Inhibitor Heavy Chain 4) Is a New Acute-Phase Protein Isolated from Cattle during Experimental Infection

Mouse Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein is an Acute Phase Protein Induced by Inflammation

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