ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer

Li, Yue; Fan, Li; Bai, Xiaoyu; Li, Yanlei; Ni, Chunsheng; Zhao, Xiulan; Zhang, Danfang

doi:10.3389/fonc.2021.658547

Cited by 21 publications

(22 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neutrophils infiltrating into the primary tumor interact with circulating tumor cells (CTCs) in the bloodstream and are involved in the establishment of a metastatic niche [ 37 , 38 ]. Circulating monocytes are recruited into breast tumors through chemotactic signals and then differentiate into TAMs to promote tumor growth and metastasis [ 39 , 40 ]. TAMs are transformed into M2 macrophages to enhance tumor angiogenesis in advanced tumors [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer

Fan

Sun

et al. 2021

BMC Cancer

Self Cite

View full text Add to dashboard Cite

Background The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives immune cell infiltration in breast cancer (BRCA) remain uncertain. Methods Oncomine, Timer and UALCAN were used to analyze the expression of eIF4E in various cancers. PrognoScan, Kaplan–Meier plotter, and GEPIA were utilized to analyze the prognostic value of eIF4E in select cancers. In vitro cell experiments were used to verify the role of eIF4E in promoting the progression of BRCA. ImmuCellAI and TIMER database were used to explore the relationship between eIF4E and tumor infiltrating immune cells. The expression of a macrophage marker (CD68+) and an M2-type marker (CD163+) was evaluated using immunohistochemistry in 50 invasive BRCA samples on tissue microarrays. The Human Protein Atlas (HPA) database was used to show the expression of eIF4E and related immune markers. LinkedOmics and NetworkAnalyst were used to build the signaling network. Results Through multiple dataset mining, we found that the expression of eIF4E in BRCA was higher than that in normal tissues, and patients with increased eIF4E expression had poorer survival and a higher cumulative recurrence rate in BRCA. At the cellular level, BRCA cell migration and invasion were significantly inhibited after eIF4E expression was inhibited by siRNA. Immune infiltration analysis showed that the eIF4E expression level was significantly associated with the tumor purity and immune infiltration levels of different immune cells in BRCA. The results from immunohistochemical (IHC) staining further proved that the expression of CD68+ and CD163+ were significantly increased and correlated with poor prognosis in BRCA patients (P < 0.05). Finally, interaction network and functional enrichment analysis revealed that eIF4E was mainly involved in tumor-related pathways, including the cell adhesion molecule pathway and the JAK-STAT signaling pathway. Conclusions Our study has demonstrated that eIF4E expression has prognostic value for BRCA patients. eIF4E may act as an essential regulator of tumor macrophage infiltration and may participate in macrophage M2 polarization.

show abstract

Section: Discussionmentioning

confidence: 99%

High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer

Fan

Sun

et al. 2021

BMC Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Among the ITGAs, ITGA3 in previous studies has been reported elevated in many cancers, including bladder cancer [21], thyroid carcinoma [22], non-small cell lung cancer [23], breast cancer [24], head and neck cancer [25], tongue cancer [26], and colorectal cancer [27]. However, there is only limited evidence regarding the expression of ITGA3 in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis on the Expression and Prognostic value of ITGA Family in Human Pancreatic Adenocarcinoma

Yang

Gao

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Pancreatic adenocarcinoma (PAAD) is the most common histological subtype of pancreatic cancer. Although dramatic progress has been made in multimodal therapies, PAAD still has a poor diagnosis and prognosis. The integrin α (ITGA) family genes play a fundamental role in different cancers. However, the potential values of ITGA family members in PAAD remain elusive. This study aimed to analyze the relationship between and ITGA family genes and PAAD.Methods: A variety of bioinformatic approaches, including UALCAN, GEPIA, Human Protein Atlas (HPA) database, Kaplan-Meier Plotter, cBioPortal, and STRING, which were used to analyze the potential roles of ITGA family members in human PAAD. The results were further verified in PAAD cell lines.Results: The transcriptional levels of ITGA 1/2/3/5/6/9/11 were up-regulated, whereas the expression of ITGA 4/8/10 were not obvious in patients with PAAD compared with that in normal pancreas. And a noticeable correlation was also discovered between the over-expressions of ITGA 2/3/5/6/11 and the clinical cancer stages of PAAD patients. Survival analysis revealed that the high mRNA expression of ITGA 2/3/5/6 and 11 were associated with overall survival (OS) in PAAD patients.Conclusion: Detection of ITGA genes has values in the diagnosis and prognosis of PAAD. ITGA 2/3/5/6/11 might serve as indicators of tumor stages of PAAD, while ITGA 2/5 may be new biomarkers for evaluating the prognosis of PAAD.

show abstract

“…Furthermore, increased integrin β1/lnc005620 regulated chemoresistance to epirubicin in TNBC in vitro and in vivo ( 139 ). However, integrin α3 is a favorable prognostic biomarker in breast cancer via integrin α3-ECM mediated immune cell infiltration ( 173 ). Increased integrin α5 expression induces lower aggressiveness in tamoxifen-resistant breast cancer ( 174 ).…”

Section: Integrin and Endocrine-related Cancersmentioning

confidence: 99%

Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

et al. 2022

View full text Add to dashboard Cite

Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial–mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.

show abstract

ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer

Cited by 21 publications

References 63 publications

High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer

High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer

Comprehensive Analysis on the Expression and Prognostic value of ITGA Family in Human Pancreatic Adenocarcinoma

Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

Contact Info

Product

Resources

About