Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

Ruan, Yongsheng; Chen, Libai; Xie, Dong; Luo, Tingting; Xu, Yiqi; Ye, Tao; Chen, Xiaona; Feng, Xi‐Qiao; Wang, Xuedong

doi:10.3389/fendo.2022.865436

Cited by 7 publications

(4 citation statements)

References 207 publications

(231 reference statements)

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“…The dark reddish purple (Black group) and light peacock green (Green group) are linked to the cell adhesion molecules (CAMs) pathway ( Figure 8 F). CAMs are cell surface molecules that promote cell-to-cell or cell-matrix binding, exerting adhesion and triggering intracellular signaling, thereby regulating various cellular activities ( Ruan et al, 2022 ). The light peacock green (Green group) may exhibit a stronger cell adhesion effect through myelin protein zero ( MPZ ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome and proteome revealed the differences in 3 colors of earlobe in Jiangshan Black-bone chicken

Li,

Du,

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Transcriptome and proteome revealed the differences in 3 colors of earlobe in Jiangshan Black-bone chicken

Li,

Du,

et al. 2024

Poultry Science

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“…Cell adhesion molecules on the cell surface are involved in numerous physiological processes such as cell adhesion, survival, proliferation, epithelial–mesenchymal transition, and drug resistance [ 46 ]. Podocytes are anchored to the GBM via many types of cell adhesion molecules [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment

et al. 2023

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Podocytes play a critical role in maintaining normal glomerular filtration, and podocyte loss from the glomerular basement membrane (GBM) initiates and worsens chronic kidney disease (CKD). However, the exact mechanism underlying podocyte loss remains unclear. Fructose-2,6-biphosphatase 3 (PFKFB3) is a bifunctional enzyme that plays crucial roles in glycolysis, cell proliferation, cell survival, and cell adhesion. This study aimed to determine the role of PFKFB3 in angiotensin II (Ang II) kidney damage. We found that mice infused with Ang II developed glomerular podocyte detachment and impaired renal function accompanied by decreased PFKFB3 expression in vivo and in vitro . Inhibition of PFKFB3 with the PFKFB3 inhibitor 3PO further aggravated podocyte loss induced by Ang II. In contrast, activating PFKFB3 with the PFKFB3 agonist meclizine alleviated the podocyte loss induced by Ang II. Mechanistically, PFKFB3 knockdown likely aggravate Ang II-induced podocyte loss by suppressing talin1 phosphorylation and integrin beta1 subunit (ITGB1) activity. Conversely, PFKFB3 overexpression protected against Ang II-induced podocyte loss. These findings suggest that Ang II leads to a decrease in podocyte adhesion by suppressing PFKFB3 expression, and indicates a potential therapeutic target for podocyte injury in CKD.

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“…Cell adhesion is also an important factors in tumor cell metastasis. Cell adhesion molecules plays a pivotal role in adhesion, triggers intracellular signal transduction, and participates in the regulation of EMT, thereby participating in the progression of distant metastasis of tumor cells ( Ruan et al, 2022 ).…”

Section: Mechanisms Of Malignant Tumor Metastasismentioning

confidence: 99%

Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis

Zhou,

Lan,

Liu

et al. 2024

Front. Pharmacol.

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Osteosarcoma (OS) is a malignant tumor originating from mesenchymal tissue. Pulmonary metastasis is usually present upon initial diagnosis, and metastasis is the primary factor affecting the poor prognosis of patients with OS. Current research shows that the ability to regulate the cellular microenvironment is essential for preventing the distant metastasis of OS, and anoxic microenvironments are important features of solid tumors. During hypoxia, hypoxia-inducible factor-1α (HIF-1α) expression levels and stability increase. Increased HIF-1α promotes tumor vascular remodeling, epithelial-mesenchymal transformation (EMT), and OS cells invasiveness; this leads to distant metastasis of OS cells. HIF-1α plays an essential role in the mechanisms of OS metastasis. In order to develop precise prognostic indicators and potential therapeutic targets for OS treatment, this review examines the molecular mechanisms of HIF-1α in the distant metastasis of OS cells; the signal transduction pathways mediated by HIF-1α are also discussed.

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Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

Cited by 7 publications

References 207 publications

Transcriptome and proteome revealed the differences in 3 colors of earlobe in Jiangshan Black-bone chicken

Transcriptome and proteome revealed the differences in 3 colors of earlobe in Jiangshan Black-bone chicken

PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment

Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis

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