Italy's nutraceutical industry: a process and bioeconomy perspective into a key area of the global economy

Pagliaro, Mario

doi:10.1002/bbb.2059

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…Considering the Italian scenario, about 32 million citizens use dietary supplements, and among these, 18 million use them on a regular (daily or weekly) basis. It has been estimated that Italy's nutraceutical market grew by 126% in the period between 2008 and 2018, during which revenues increased from EUR 1.3 billion to EUR 3.3 billion [24]. Dietary supplements for lipid control based on RYR represented the fourth most important class of nutraceuticals in terms of values during 2017-2018 after probiotics, mineral supplements, and multivitaminmultimineral supplements [24].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market

Marcheluzzo

Faggian²,

Zancato

et al. 2021

Molecules

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The use of dietary supplements for the prevention and management of diseases associated with excess of lipids is spreading in Western countries. Supplements containing red yeast rice (RYR) and extracts from Berberis species, characterized, respectively, by the active compounds monacolin K (MK) and berberine (BBR), are sold in pharmacies as over the counter medicines (OTC) and in regular markets without the need of medical prescription and medical surveillance. However, MK is chemically identical to lovastatin, a drug commonly used to treat hypercholesterolemia, and is characterized by the same mechanism of action, pharmacokinetic profile and toxicity. On the other hand, although BBR-containing supplements are considered to be well-tolerated and safe, they frequently show poor standardization of active ingredients, and this could lead to lack of effects. In this work, with the aim to give an overview on the potency of RYR- and BBR-containing supplements available on the Italian market, we analyzed a pool of supplements bought from both local pharmacies and markets. Results confirm the data already published by other authors, showing scarce standardization of bioactives and discrepancy between the doses of bioactives reported by the manufacturers and the amounts resulting from analysis of the same products. Overall, our data represent a further proof that a strict legislation regulating the production and marketing of dietary supplements and a close monitoring of these products by food and drug regulatory organs is mandatory.

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Section: Discussionmentioning

confidence: 99%

Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market

Marcheluzzo

Faggian²,

Zancato

et al. 2021

Molecules

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“…Finally, the global nutraceutical industry has experienced dramatic growth. Revenue of $231 billion in 2018 is projected to grow at a 7.8% compound annual growth rate from 2018 to 2023 [85]. The growth of Italy's nutraceuticals market, currently the largest in Europe, accompanied that of the rest of the world.…”

Section: Discussionmentioning

confidence: 99%

“…These strategies include loading vitamin E in nanovesicles, solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), nanoemulsions and polymeric nanoparticles (Figure 5). Noting the absence of a shared definition of nutraceuticals, scholars have recently argued that 'the effective use of nutraceuticals in prevention and therapy' is limited by 'the lack of clinical data substantiating in full their efficacy which prevents the obtainment and use on the label of a health claim [85,86]. The industry, however, is aware of the need to support and promote an evidencebased approach.…”

Section: Nanoformulations and Substantiating The Health Benefitsmentioning

confidence: 99%

Biotechnology of Nanostructures Micronutrients Vitamins for Human Health

Madkour¹

2021

J NanoSci Res Rep

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Nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs and nutrients. Micronutrients and nutraceuticals such as vitamins, carotenoids, polyunsaturated fatty acids and polyphenols are classes of food ingredients that are essential for human health and well-being. These compounds are rarely added purely to the targeted food application but rather in encapsulated, solid, dry product forms with added functionalities such as improved stability, bioavailability or handling. Development of new strategies, like nanocarriers, that help to promote the access of neuroprotective molecules to the brain, is needed for providing more effective therapies for the disorders of the central nervous system (CNS). Polymer–lipid hybrid nanoparticles, encapsulating vitamin D3 and vitamin K2, with improved features in terms of stability, loading and mucoadhesiveness were produced for potential nutraceutical and pharmaceutical applications. Recently, nanoformulations that include nanovesicles, solid-lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and polymeric nanoparticles have shown promising outcomes in improving the efficacy and bioavailability of vitamin E. Active targeting of nanoparticles loaded with vitamin D to cancer cells.

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“…Limited consumer interest and acceptance may be a major stumbling block to the progress of a circular bio-economy [300,332]. Generating awareness among, disseminating information to, seeking consent and acceptance from and respecting the opinions of all the stakeholders, social groups and competent authorities involved, is of paramount importance, as Kokkinos et al After all, a circular bio-economy is a political (inter-governmental), industrial and societal initiative, necessitating, inter alia: & instillation of a flexible and encouraging organisational change culture in the value chains [211,225] & stronger private-public partnerships [323] & innovative approaches in addition to 'technology-push' traditional R&D or a piecemeal approach to different technologies [323] & willingness to establish bio-based industries to attain self-sufficiency in essential commodities (as exemplified for bio-nutraceuticals in Italy [268]) & collaborations between 'conventional and non-conventional entities' in the economy [322] among various disciplines in academic and industrial research [288] & rural recapitalisation and integration of marginalised communities [226] & robust institutional structures at local and regional levels [363] & systems thinking at all levels [364,365] & strong governance, an effective policy mix, appropriate legal framework conditions and innovative approaches [227,340,366] & a revamp of quality standards to accommodate recycled bio-products [166] & changes in entire systems through the joint efforts of researchers, technology centres, industries, the primary sector, new entrepreneurs, consumers, civil society and governments [140,291,324,325,330] & reimagination of cities which house over 50% of the global population, are centres of direct and indirect consumption of resources and are often vilified as exporters of ecological 'bads', as sites of bioeconomic value [367] It is here that post-modern technologies like cloud computing, social networks and big data promise to be useful enablers [301], while bioinformatics [368] and econometric models [241]…”

Section: Generalmentioning

confidence: 99%

Circular Bio-economy—Paradigm for the Future: Systematic Review of Scientific Journal Publications from 2015 to 2021

Govindarajan

2021

Circ.Econ.Sust.

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While ‘renewable’ is the keyword in a bioeconomy and resource conservation is the motivation behind a circular economy, a circular bioeconomy is one in which waste streams from renewable bio-resources are looped back into the technosphere—open-loop or closed-loop recycling or conversion from matter to energy. This systematic review brings together 385 publications from 2015 to 2021, originating from 50 countries and appearing in 150 journals, into a coherent account of the status quo of published research on circular bioeconomy. The numbers bear testimony to the growing interest in this field of research. Germany is the leading contributor to the scientific literature base (10%), while the Journal of Cleaner Production (9%) tops the list of journals in the fray. The methodology adopted has been clearly explained, and the discussion has been segmented into sub-sections and sub-sub-sections to do justice to the diversity of the nature of the publications. A little flexibility in organisation of the flow of the text has been availed of, to improve readability. The circular bioeconomy can be visualised as a set of ‘many through many to many’ relationships, enabling both economies of scale and scope in the longer run. This calls for extensive collaboration and cooperation among the numerous stakeholders involved. Several barriers will have to be overcome. Technology impact assessments and sustainability risk appraisals need to be carried out in order to ensure and convince stakeholders that they are on the right path. But as one knows and will appreciate, challenges lurk where there exist opportunities to be availed of, to replace the take-make-use-dispose paradigm of a linear economy to the grow-make-use-restore alternative. Graphical abstract

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Italy's nutraceutical industry: a process and bioeconomy perspective into a key area of the global economy

Cited by 10 publications

References 34 publications

Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market

Analysis of Monacolins and Berberine in Food Supplements for Lipid Control: An Overview of Products Sold on the Italian Market

Biotechnology of Nanostructures Micronutrients Vitamins for Human Health

Circular Bio-economy—Paradigm for the Future: Systematic Review of Scientific Journal Publications from 2015 to 2021

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