Italian young doctors’ knowledge, attitudes and practices on antibiotic use and resistance: A national cross-sectional survey

Gennaro, Francesco Di; Marotta, Claudia; Amicone, Maria; Bavaro, Davide Fiore; Bernaudo, F.; Frisicale, Emanuela Maria; Kurotschka, Peter Konstantin; Mazzari, Andrea; Veronese, Nicola; Murri, Rita; Fantoni, Massimo

doi:10.1016/j.jgar.2020.08.022

Cited by 59 publications

(58 citation statements)

References 19 publications

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“…In addition, 81% of participants said that ASP was not properly handled during their medical training, and 71% said they did not learn appropriate examples from their tutors. Therefore, proper ASP education for medical doctors is very desperately needed [24].…”

Section: Discussionmentioning

confidence: 99%

Rapid Molecular Tests for Detecting Respiratory Pathogens Reduced the Use of Antibiotics in Children

et al. 2021

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Multiplex polymerase chain reaction (mPCR) is increasingly being used to diagnose infections caused by respiratory pathogens in pediatric inpatient facilities. mPCR assays detect a broader array of viruses, with higher specificity and sensitivity and faster turnaround than previous assays. We adapted the FilmArray Respiratory Panel (FA-RP) for diagnosing respiratory infections. FA-RP is an in vitro mPCR assay that simultaneously and rapidly (in about 1 h) detects 20 pathogens directly from respiratory specimens. Here, we studied the clinical efficacy of FA-RP in children who underwent testing for respiratory pathogens at Yeungnam University Hospital from November 2015 to August 2018. From November 2015 to June 2016, routine mPCR testing was performed on nasopharyngeal swabs using the routine mPCR kit. From November 2016 to July 2018, mPCR testing was performed using FA-RP. A total of 321 tests by routine mPCR and 594 tests by FA-RP were included. The positive detection rates for routine mPCR and FA-RP were 71.3% and 83.3%, respectively. FA-RP reduced the lead time, waiting time, turnaround time, intravenous (IV) antibiotic use, and length of hospital stay for pediatric patients. The decreased use of antibiotics is expected to reduce antibiotic resistance in children.

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Section: Discussionmentioning

confidence: 99%

Rapid Molecular Tests for Detecting Respiratory Pathogens Reduced the Use of Antibiotics in Children

et al. 2021

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“…Preoperative bathing, surgical site preparation, surgical hand preparation, adequate use of antibiotics to reduce the risk of infection, and surgical wound irrigation are the main prevention strategies of SSI [5,19]. Moreover, the Prophylactic antibiotics for all CD was used as general recommendation to prevent SSI and it reduces the risk of infection by up to 75% [20].…”

Section: Introductionmentioning

confidence: 99%

Magnitude and factors associated with surgical site infection among mothers underwent cesarean delivery in Nekemte town public hospitals, western Ethiopia

et al. 2021

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Background Surgical site infection (SSI) is a serious public health problem due to its impacts on maternal morbidity and mortality and it can have a significant effect on quality of life for the patient. However, little has been studied regarding the magnitude and factors associated with SSI among women underwent cesarean delivery (CD) in study area. Therefore, the aim of this study was to assess the magnitude and factors associated with SSI among women underwent cesarean delivery in Nekemte Town Public Hospitals 2020. Methods An institution based cross-sectional study was conducted from January 1/2018 to January 1/2020. A simple random sampling technique was employed to select 401 patient cards from all records women underwent CD from January 1/2018 to January 1/2020. Epidata version 3.2 was used for data entry, and STATA version 14 was used for analysis. A logistic regression model was used to determine the association of independent variables with the outcome variable and adjusted odds ratios (AOR) with 95% confidence interval was used to estimate the strength of the association. Results Three hundred eight two (382) cards of women were selected for analysis making a response rate of 95.2%. The mean (±SD) age of the mothers was 25.9 (±4.8) years. The prevalence of SSIs was 8.9% (95% CI: 6.03, 11.76). Age > 35 years (AOR = 5.03, 95% CI:1.69, 14.95), pregnancy-induced hypertension (AOR = 5.63, 95%CI:1.88, 16.79), prolonged labor (AOR = 4.12, 95% CI:1.01, 32.19), receiving general anesthesia (AOR = 3.96 95% CI:1.02, 15.29), and post-operative hemoglobin less than 11 g/dl (AOR = 4.51 95% CI:1.84, 11.07) were significantly associated with the occurrence of SSI after cesarean delivery. Conclusions and recommendations The magnitude of post CD SSI in this study was comparable with the sphere standards of CDC guidelines for SSI after CD. Concerned bodies should give due attention the proper utilization of partograph to prevent prolonged labor, and provision of iron folate to increase the hemoglobin level of pregnant mothers in all health institution. In addition, we would recommend the use of spinal anesthesia over general anesthesia.

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“…Antimicrobial resistance is a global issue threatening public safety. All healthcare professionals should be aware of the knowledge on antimicrobial resistance and the rational use of antimicrobial agents [17]. The potential and emergence of levornidazole resistance in pathogenic anaerobes should be monitored closely in future trials and clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis

Wu¹,

Wang²,

Yü³

et al. 2021

Infect Dis Ther

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Introduction:Levornidazole is a novel nitroimidazole antimicrobial agent active against anaerobes. We aimed to investigate the pharmacokinetic (PK) profile of levornidazole and PTA [ 99% for B. fragilis (minimum inhibitory concentration B 1.0 mg/l) infections. Conclusion: Levornidazole tablets are absorbed rapidly and completely and distributed extensively with a long half-life and low urinary excretion after a single dose or multiple doses in healthy Chinese subjects. Levornidazole tablets can be taken with or without food. Levornidazole tablets 500 mg q12h and 750 mg q24h are expected to achieve the desired efficacy in B. fragilis infections. Clinical Trail Registration: Trial registration number CTR20160786 at http://www.china drugtrials.org.cn/.

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Italian young doctors’ knowledge, attitudes and practices on antibiotic use and resistance: A national cross-sectional survey

Cited by 59 publications

References 19 publications

Rapid Molecular Tests for Detecting Respiratory Pathogens Reduced the Use of Antibiotics in Children

Rapid Molecular Tests for Detecting Respiratory Pathogens Reduced the Use of Antibiotics in Children

Magnitude and factors associated with surgical site infection among mothers underwent cesarean delivery in Nekemte town public hospitals, western Ethiopia

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis

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