Itaconic acid production from wheat chaff by Aspergillus terreus

Krull, Susan; Eidt, Laslo; Hevekerl, Antje; Kuenz, Anja; Prüße, Ulf

doi:10.1016/j.procbio.2017.08.010

Cited by 47 publications

(29 citation statements)

References 45 publications

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“…To the best of our knowledge, deionization of potato waste hydrolysate for IA production is not yet reported in the literature, although deionization of other waste substrates has been investigated by a few studies. Improved IA production by A. terreus was reported by deionization of wheat chaff hydrolysate with cation exchange resin, and deionization of beech wood hydrolysate with equal mixture of anion‐ and cation‐exchangers. The result obtained in this study was different in terms of use of only anion exchange resin for deionization.…”

Section: Discussionmentioning

confidence: 62%

Optimization and scale up of itaconic acid production from potato starch waste in stirred tank bioreactor

Bafana

Sivanesan

Pandey

2019

Biotechnology Progress

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Present study used Aspergillus terreus strain C1 isolated from mangrove soil for itaconic acid (IA) production from potato starch waste. Fermentation parameters were optimized by classical one factor approach and statistical experimental designs, such as Plackett-Burman and response surface designs. Anionic deionization of potato waste was found to be a very effective, economic, and easy way of improving IA production. The increase in IA production by deionization was found to correlate with removal of phosphate. In our knowledge, this is the first report on application of deionization of potato waste to enhance IA production. Other parameters like inoculum development conditions, pH, presence of peptone and certain salts in the medium also significantly affected IA production. IA production by strain C1 increased 143-fold during optimization when compared with the starting condition. The optimized IA level (35.75 g/L) was very close to the maximum production predicted by RSM (38.88 g/L). Bench scale production of IA was further optimized in 3-L stirred tank reactor by varying parameters like agitation and aeration rate. The maximum IA production of 29.69 g/L was obtained under the agitation speed of 200 rpm and aeration rate of 0.25 vvm. To the best of our knowledge, it is the first report on IA production from potato starch waste at bioreactor level.

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Section: Discussionmentioning

confidence: 62%

Optimization and scale up of itaconic acid production from potato starch waste in stirred tank bioreactor

Bafana

Sivanesan

Pandey

2019

Biotechnology Progress

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“…Organic acids , such as citric and lactic acid, have direct applications in the food industry. Succinic, lactic, and itaconic acids are examples of precursors of polymer synthesis that can replace petrochemical‐based products . Organic acids can be produced by the fermentation of sugars, such as glucose, xylose, and sucrose .…”

Section: Lignocellulosic Biomass From Agro‐industrial Residuesmentioning

confidence: 99%

Lignocellulosic biomass from agro‐industrial residues in South America: current developments and perspectives

Magalhães

Carvalho

Pereira

et al. 2019

Biofuels Bioprod Bioref

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South America is a pivotal supplier of agricultural commodities for a growing world population. This large-scale production generates a substantial amount of lignocellulosic residue. Inadequate disposal of this material can lead to putrefaction and leaching, and can attract insects and rodents. Solid residues can be treated by incineration or composting -both causing greenhouse gas emissions. Biotransformation of lignocellulosic residues into valuable products has been proposed as a more sophisticated alternative to burning. However, pretreatment steps are necessary to obtain fermentable sugars for biological or thermochemical transformation into value-added products. In this review, we noted trends in lignocellulosic biomass generation and potential uses, with special attention to the procedures necessary for the generation of fermented products and bio-oil. This survey pointed out that sugarcane bagasse, cereal straws, bananas, and oil-palm biomass can generate about 900 million tonnes of biomass by 2025. Based on production data from several researchers it was estimated that these raw materials have the potential for annual production of more than 550 million tonnes of fermentable sugars (i.e., glucose and xylose), 670 million tonnes of bio-oil, or 4000 TWh of thermal energy. We describe procedures and strategies for the conversion of these residues to produce higher value-added biomolecules and to promote more sustainable application of lignocellulosic biomass

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“…A. terreus was able to utilize multiple sugars derived from lignocellulosic biomass to produce IA . Recently, several research articles, with varying success, have demonstrated the production of IA using A. terreus from lignocellulosic hydrolyzates . Tippkötter et al reported that A. terreus NRRL 1960 could not grow on untreated organosolv beech wood hydrolyzate.…”

Section: Introductionmentioning

confidence: 99%

“…13 Recently, several research articles, with varying success, have demonstrated the production of IA using A. terreus from lignocellulosic hydrolyzates. [14][15][16][17] Tippkötter et al 14 reported that A. terreus NRRL 1960 could not grow on untreated organosolv beech wood hydrolyzate. Several detoxification methods were then used to remove the fermentation inhibitors.…”

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confidence: 99%

Efficient itaconic acid production by Aspergillus terreus: Overcoming the strong inhibitory effect of manganese

Saha

Kennedy

2019

Biotechnology Progress

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Itaconic acid (IA), a building block platform chemical, is produced industrially by Aspergillus terreus utilizing glucose. Lignocellulosic biomass can serve as a low cost source of sugars for IA production. However, the fungus could not produce IA from dilute acid pretreated and enzymatically saccharified wheat straw hydrolyzate even at 100‐fold dilution. Furfural, hydroxymethyl furfural and acetic acid were inhibitory, as is typical, but Mn2+ was particularly problematic for IA production. It was present in the hydrolyzate at a level that was 230 times over the inhibitory limit (50 ppb). Recently, it was found that PO43− limitation decreased the inhibitory effect of Mn2+ on IA production. In the present study, a novel medium was developed for production of IA by varying PO43−, Fe3+ and Cu2+ concentrations using response surface methodology, which alleviated the strong inhibitory effect of Mn2+. The new medium contained 0.08 g KH2PO4, 3 g NH4NO3, 1 g MgSO4·7H2O, 5 g CaCl2·2 H2O, 0.83 mg FeCl3·6H2O, 8 mg ZnSO4·7H2O, and 45 mg CuSO4·5H2O per liter. The fungus was able to produce IA very well in the presence of Mn2+ up to 100 ppm in the medium. This medium will be extremely useful for IA production in the presence of Mn2+. This is the first report on the development of Mn2+ tolerant medium for IA production by A. terreus.

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Itaconic acid production from wheat chaff by Aspergillus terreus

Cited by 47 publications

References 45 publications

Optimization and scale up of itaconic acid production from potato starch waste in stirred tank bioreactor

Optimization and scale up of itaconic acid production from potato starch waste in stirred tank bioreactor

Lignocellulosic biomass from agro‐industrial residues in South America: current developments and perspectives

Efficient itaconic acid production by Aspergillus terreus: Overcoming the strong inhibitory effect of manganese

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