Istopathlogical Changes Caused by the Exposure of Super Benzene on Haematopoietic Tissues (Spleen and Bone Marrow) in Experimental Rats ( Rattus Norvigicus

Abstract

The present study was carried out to determine the effect of super benzene inhalathion and its metabolites on haemopoietic tissues(spleen and bone marrow) on experimental rats.Animals were exposed via inhalation to concentrations of (5 and 10) ppm super benzene for 2 hour/day, 5 days /week for 3 months.Histological studies revealed that spleen of the exposed animals to super benzene, were exposed to 5 ppm showed white pulp atrophy and absence of megakaryocytes in red pulp with blood vessels congestion.In 10 ppm showed increased of extramedulary haemopoiesis, acute splenitis and fibrosis as well as showed aggregation of lymphocytes in lymph node, thickness with centeral artery wall also inflammation of inflammatory cells inside centeral artery and vasodilatation in centeral artery in asplenic nodule.While the bone marrow related to the animals exposed to 5 and 10 ppm showed reduced in haemapoietic tissue which partly replaced by adipose tissue.