Issues Related to Institutional Animal Care and Use Committees and Clinical Trials Using Privately Owned Animals

Baneux, P.; Martin, Mary E.; Allen, Matthew J.; Hallman, Troy

doi:10.1093/ilar/ilu005

Cited by 17 publications

(15 citation statements)

References 3 publications

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“…The dog owners gave his/her written consent for sample collection and data publication. Besides, according to Dr. Baneux’ recommendations “Privately owned animals that are recruited for clinical studies (not Public Health Service funded) do not need to be subjected to IACUC oversight as long as their involvement includes only procedures that are consistent with the standard of care provided to patients with the same diagnosis that are not included in the clinical study” [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

High detection rate of dog circovirus in diarrheal dogs

Hsu

Lin

et al. 2016

BMC Vet Res

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BackgroundDiarrhea is one of the most common clinical symptoms reported in companion animal clinics. Dog circovirus (DogCV) is a new mammalian circovirus that is considered to be a cause of alimentary syndromes such as diarrhea, vomiting and hemorrhagic enteritis. DogCV has previously only been identified in the United States, Italy, Germany (GeneBank accession number: KF887949) and China (GeneBank accession number: KT946839). Therefore, the aims of this study were to determine the prevalence of DogCV in Taiwan and to explore the correlation between diarrhea and DogCV infection. Clinical specimens were collected between 2012 and 2014 from 207 dogs suffering from diarrhea and 160 healthy dogs.ResultsIn this study, we developed a sensitive and specific SYBR Green-based real-time PCR assays to detected DogCV in naturally infected animals. Of the analyzed fecal samples from diarrheal dogs and health dogs, 58 (28.0 %) and 19 (11.9 %), respectively, were DogCV positive. The difference in DogCV prevalence was highly significant (P = 0.0002755) in diarrheal dogs.ConclusionsThis is the first study to reveal that DogCV is currently circulating in domestic dogs in Taiwan and to demonstrate its high detection rate in dogs with diarrhea.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-016-0722-8) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

High detection rate of dog circovirus in diarrheal dogs

Hsu

Lin

et al. 2016

BMC Vet Res

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“…81,201 Last, clinical trials involving dogs can be limited by rigorous scientific and ethical review, unpredictable case enrollment, variability in disease phenotype among patients, economic challenges (e.g., owner ability to provide care), and owner compliance, to name a few. 6,321 SEBBAG AND MOCHEL | 2591…”

Section: Limitations Of Using Dogs For Translational Researchmentioning

confidence: 99%

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Sebbag

Mochel

2020

Medicinal Research Reviews

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Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (i.e., rabbits, mice, and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help accelerate and improve the framework in which ophthalmic research is translated to the human clinic. Studies can be conducted in canine subjects with naturally occurring or noninvasively induced ocular surface disorders (e.g., dry eye disease, conjunctivitis), reviewed herein, and tear fluid can be easily retrieved from canine eyes for various bioanalytical purposes. In this review, we discuss common tear collection methods, including capillary tubes and Schirmer tear strips, and provide guidelines for tear sampling and extraction to improve the reliability of analyte quantification (drugs, proteins, others).

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“…Much like clinical trials in children, sick animals are unable to accept or decline experimental treatment, and so their owners are entrusted to make these decisions on their behalf and to provide legal guardianship. The American Veterinary Medical Association (AVMA) supports clinical studies and therapy directed at naturally occurring diseases in animals with a goal to inform human medical issues (52). In this regard, each study should be reviewed at the institutional level either by the Institutional Animal Care and Use Committee (IACUC), a Clinical Trials Review Board, or a combination of such committees to ensure thorough scientific and ethical review.…”

Section: Ethical Considerationsmentioning

confidence: 99%

Companion animals: Translational scientist’s new best friends

et al. 2015

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Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.

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Issues Related to Institutional Animal Care and Use Committees and Clinical Trials Using Privately Owned Animals

Cited by 17 publications

References 3 publications

High detection rate of dog circovirus in diarrheal dogs

High detection rate of dog circovirus in diarrheal dogs

An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

Companion animals: Translational scientist’s new best friends

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