2015
DOI: 10.1126/scitranslmed.aaa9116
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Companion animals: Translational scientist’s new best friends

Abstract: Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring disea… Show more

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Cited by 145 publications
(171 citation statements)
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“…These diseases in companion animals may better reflect the complex genetic, environmental, and physiological variations present in human diseases compared to induced diseases in laboratory animals [20]. Clinical trials in academic veterinary medicine mirror that of human healthcare systems, and animal owners are eager to enroll in these trials [20].…”
Section: Introductionmentioning
confidence: 99%
“…These diseases in companion animals may better reflect the complex genetic, environmental, and physiological variations present in human diseases compared to induced diseases in laboratory animals [20]. Clinical trials in academic veterinary medicine mirror that of human healthcare systems, and animal owners are eager to enroll in these trials [20].…”
Section: Introductionmentioning
confidence: 99%
“…Hence, surgical joint destabilization is the most frequently employed model. Although the value of these rapidly changing rodent OA models should not be underestimated, naturally occurring disease in companion animals more closely reflects the complex genetic, physiological and environmental variations that occur in human OA 9,10 .…”
mentioning
confidence: 99%
“…Academic and private practice veterinary medicine can provide valuable biomedical research data, as referral centres are often equipped with MRI and CT scanners, arthroscopes and state-of-theart pathology and molecular diagnostic capabilities. Academic veterinary centres also pilot advances in the use of anti-inflammatory and pain-modulating OA drug therapies 10,14,15 . In this Review, we summarize research relating to common forms of spontaneous dog OA, focusing on the presentation and genetics of analogous diseases of the hip and knee, within a framework of human OA phenotypes.…”
mentioning
confidence: 99%
“…Nonetheless, a study of naturally occurring diseases is superior to the study of induced disease in rodent models. 49 The number of dogs included in our study was relatively small, although comparable to numbers typically seen in published rodent model studies. The variability that existed among the dogs included in the study, and the relatively small number of animals studied, render some of the statistical comparisons underpowered, increasing the likelihood of type II error.…”
Section: Discussionmentioning
confidence: 56%
“…Moreover, variability existed in medical interventions administered to control secondary hyperparathyroidism (e.g., phosphorous binders). Nonetheless, a study of naturally occurring diseases is superior to the study of induced disease in rodent models . The number of dogs included in our study was relatively small, although comparable to numbers typically seen in published rodent model studies.…”
Section: Discussionmentioning
confidence: 75%