Issues of pathology of a new coronavirus infection CoVID-19

Zinserling, Vsevolod; Vashukova, М. А.; Vasilyeva, Marina; Isakov, A. N.; Lugovskaya, N. A.; Narkevich, T. A.; Sukhanova, Yu. V.; Semenova, N. Yu.; Гусев, Д. А.

doi:10.22625/2072-6732-2020-12-2-5-11

Cited by 33 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pathological investigation was done by using bright lineage of immunohistochemistry (CD2, 3,5,7,8,20,31,34,69). Our study allowed us to demonstrate the role of different mechanisms of death [128]. Of special interest was the diffuse infiltration of the lungs, along with focal infiltration of the kidney, liver, intestine, adrenals, pancreas and pericard by lymphocytes, which were seen in different grade in all our cases.…”

Section: Probable Histopathological Signs Of Autoimmune Reactions In mentioning

confidence: 80%

Covid-19 and autoimmunity

Ehrenfeld

Tincani

Andréoli

et al. 2020

Autoimmunity Reviews

454

416

View full text Add to dashboard Cite

show abstract

Section: Probable Histopathological Signs Of Autoimmune Reactions In mentioning

confidence: 80%

Covid-19 and autoimmunity

Ehrenfeld

Tincani

Andréoli

et al. 2020

Autoimmunity Reviews

454

416

View full text Add to dashboard Cite

show abstract

“…летальных исходов, связанных с COVID-19. В ходе исследования были выявлены следующие факторы, связанные с тяжестью заболевания и смертностью: возраст старше 60 лет, мужской пол, ожирение, сахарный диабет, тяжелая степень бронхиальной астмы, заболевания дыхательных путей, хроническая сердечная недостаточность, заболевания печени, почек, инсульт, деменция и другие неврологические заболевания, хроническая болезнь почек, аутоиммунные заболевания (ревматоидный артрит, волчанка или псориаз) и прочие иммунодепрессивные состояния [6], что согласуется с результатами исследований, проведенных во многих странах мира [7][8][9][10][11][12].…”

Section: клинические формы инфекции и факторы риска неблагоприятного теченияunclassified

“…Временные рекомендации ВОЗ рекомендуют выполнять экстракорпоральную мембранную оксигенацию (ЭКМО) пациентам с острым респираторным дистресссиндромом (ОРДС), связанным с COVID-19 7 .…”

Section: современные подходы к терапииunclassified

Topical issues of diagnostics, examination and treatment of patients with COVID-19-associated pneumonia in different countries and continents

et al. 2021

View full text Add to dashboard Cite

The lack of effective etiotropic methods of treatment and prevention of the new coronavirus infection (COVID-19), which caused the pandemic in 2020, determines the relevance of the review of researches of medicines for etiotropic and pathogenetic therapy. Most patients are diagnosed with pneumonia, the disease is especially difficult in people with concomitant chronic diseases, since COVID-19 leads to their decompensation, which can lead to death. To assess risk factors for mortality, scientists are developing programs to transfer the patient to appropriate treatment in a timely manner. This article analyzes the clinical efficacy of various agents for etiotropic and pathogenetic treatment of a new coronavirus infection based on data from international researches. Etiotropic medicines used at the beginning of the pandemic did not show their effectiveness in reducing the duration of treatment, the development of death, and preventing the transition to the use of mechanical ventilation. There are described researches of vaccines against a new coronavirus infection, developed in the Russian Federation, the USA, Germany and the UK, which showed the greatest efficiency (more than 90%) in preventing COVID-19. The World Health Organization initiated the international clinical research SOLIDARITY, according to which all medicines participating in the trials have little or no effect on overall mortality, the onset of ventilation requirements and the length of hospital stay in hospitalized patients. Now, only systemic glucocorticosteroids have proven effective against severe and critical forms of COVID-19. Thus, effective etiotropic drugs for the treatment of COVID-19 have not been developing, however, an active search for these funds and the development of vaccines to prevent the incidence of coronavirus infection are underway.

show abstract

“…Морфологические признаки COVID-19 на современном этапе сводятся в основном к описанию изменений ранней (экссудативной) и поздней (пролиферативной) стадий ОРДС. Также верифицируется повреждение эндотелиоцитов микроциркуляторного русла с нарушениями в системе свертывания крови, развитием ДВС-синдрома с мультифокальным микротромбозом и последующей полиорганной дисфункцией с преобладанием острой почечной недостаточности [2,3,29…”

Section: Abstract: Covid-19 Patho-morphogenesis Covid-19 Interstitiunclassified

PULMONARY PATHOLOGY OF NEW CORONAVIRUS DISEASE (COVID- 19). THE PRELIMINARY ANALYSIS OF POST-MORTEM FINDINGS

Забозлаев

Кравченко²,

Gallyamova

et al. 2020

Journal of Clinical Practice

View full text Add to dashboard Cite

Background. Currently, the patho- and morphogenesis of a new coronavirus infection (COVID-19) is being studied in depth. Conducting a comparative analysis of the morphological changes in the lungs of deceased patients at various time periods after the onset of the first clinical symptoms. Clinical and morphological comparisons should help to increase qualified medical care for patients in the resuscitation profile and reduce hospital mortality. The aim of the study was to formulate a working hypothesis of a conceptual scheme of clinical and morphological forms of development of a new coronavirus infection (COVID-19). Methods. An analysis of 80 fatal cases was carried out in the COVID-center of the Federal Research Clinical Center of FMBA of Russia. Along with the assessment of macro- and microscopic changes in the respiratory tract, an additional histochemical staining according to van Gieson was applied and immunohistochemical studies were performed to assess the condition of the lungs with COVID-19. Results. The revealed features of diffuse alveolar damage in case of a new coronavirus infection (COVID-19) made it possible to present a working hypothesis of the pathomorphogenesis of specific acute coronavirus (COVID-19) alveolitis (pneumonitis). It goes through 3 stages-forms: fulminant, persistent and fibrotic. Each stage is conditionally limited by certain time parameters and is characterized by certain morphological characters. Dysregulatory activation of monocytic phagocytes, development of generalized microthrombosis, persistent signs of the exudative phase, pathological repair, progressive intraalveolar and interstitial fibrosis are the main links in the pathomorphogenesis of specific acute coronavirus (COVID-19) alveolitis (pneumonitis).

show abstract

Issues of pathology of a new coronavirus infection CoVID-19

Cited by 33 publications

References 10 publications

Covid-19 and autoimmunity

Covid-19 and autoimmunity

Topical issues of diagnostics, examination and treatment of patients with COVID-19-associated pneumonia in different countries and continents

PULMONARY PATHOLOGY OF NEW CORONAVIRUS DISEASE (COVID- 19). THE PRELIMINARY ANALYSIS OF POST-MORTEM FINDINGS

Contact Info

Product

Resources

About