Issues and prospects of image‐guided thermal ablation in the treatment of primary and metastatic lung tumors

Wang, Mei‐Xiang; Wei, Zhigang; Ye, Xin

doi:10.1111/1759-7714.14742

Cited by 3 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with limited respiratory function, different local therapeutic options are available, including sublobar resection, stereotaxic radiotherapy, cryoablation and microwave or radiofrequency ablation. The above-mentioned options are suitable for preserving healthy lung tissue and preventing impairment to the patient's physical state despite the lack of oncological radicality [17][18][19]. Sublobar resection is the alternative surgical choice to lobectomy for high-risk patients, characterized by marginal pulmonary function, advanced age or other severe comorbidities [20].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Robotic and Open Lobectomy for Lung Cancer in Marginal Pulmonary Function Patients: A Single-Centre Retrospective Study

Zirafa,

Manfredini,

Romano

et al. 2023

Current Oncology

View full text Add to dashboard Cite

Background: The treatment of non-small-cell lung cancer (NSCLC) patients with reduced respiratory function represents a challenge for thoracic surgeons. Minimally invasive surgery seems to be beneficial for these patients because it reduces tissue trauma and its impact on respiratory mechanics. Application of the robotic technique, the use of CO2 insufflation and longer surgical time are factors that could influence the outcomes of marginal pulmonary function patients. The objective of this study was to evaluate the impact of the robotic technique on the postoperative outcomes of patients with poor lung function. Methods: We retrospectively collected and analyzed data from consecutive marginal respiratory function patients who underwent robotic or open lobectomy for NSCLC. Data regarding clinical, operative and postoperative details were compared between the open and robotic approaches. Results: The outcomes of 100 patients with reduced respiratory function were evaluated, of whom 59 underwent open lobectomies and 41 underwent robotic lobectomies. Robotic lobectomy was characterized by a longer operative time, a reduced hospital stay and a lower incidence of postoperative complications (22% vs. 33.9%), when compared to the open approach. Conclusion: Robotic lobectomy is a safe and feasible procedure for patients with marginal pulmonary function.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of Robotic and Open Lobectomy for Lung Cancer in Marginal Pulmonary Function Patients: A Single-Centre Retrospective Study

Zirafa,

Manfredini,

Romano

et al. 2023

Current Oncology

View full text Add to dashboard Cite

show abstract

“…Yet, certain limitations exist when applying thermal ablation techniques to lung tumors. The potential of integrating thermal ablation with molecularly targeted drug therapy and immunotherapy has been explored and warrants further research (25,26).…”

Section: Overview Of Various Thermal Ablation Techniquesmentioning

confidence: 99%

Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation

Sang,

2023

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Biomarkers can offer insights into the patient’s immune response and outcomes, such as local tumor control, recurrence, overall survival, and progression-free survival. Identifying and validating such biomarkers can significantly impact clinical decision-making, leading to personalized treatment strategies and improved patient outcomes. This review provides a comprehensive overview of the current state of research on potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation, including their potential role in lung cancer management, and the challenges and future directions.

show abstract