Issledovanie intervala QT u detey i podrostkov, bol'nykh sakharnym diabetom 1 tipa, pri kholterovskom monitorirovanii EKG

Ryabykina, G V; Лаптев, Д. Н.; Соболев, А В; Seid-Gusseynov, A A; Волков, Array Ю.

doi:10.14341/2072-0351-5791

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Широко изучена взаимосвязь удлиненного QT с синдромом внезап-ной детской смерти, ишемической болезнью серд-ца, а также повышенным риском смерти у взрослых пациентов с СД2 [15][16][17]. У значительной части де-тей и подростков с СД1 отмечается удлинение ин-тервала QT [18].…”

Section: результаты и обсуждениеunclassified

The cardiovascular form of autonomous neuropathy in the adolescents with type 2 diabetes mellitus

Еремина¹,

Лаптев²,

Zilberman³

et al. 2014

Probl Endokrinol (Mosk)

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Objective. To estimate the prevalence of the cardiovascular form of autonomous neuropathy (CAN) and the factors associated with this condition in the adolescents suffering from type 2 diabetes mellitus (DM2) in comparison to the adolescents present- ing with type 1 diabetes mellitus (DM1). Material and methods. The study included 24 adolescents with DM2 and 30 ones with DM1 matched for the age, duration of the disease, and the quality of its compensation. The control group was comprised of 17 adolescents with exogenous constitutional obesity (ECO). All the patients were examined by means of Holter ECG monitoring with the estimation of the daily cardiac rhythm variability based on the mean weighted variation of rhythmogram (MWVR) and the length of the QTc interval. In addition, standard cardiovascular tests were performed including deep-breath test, the Valsalva maneuver, and the 30:15 intermittent fitness test. Cardiovascular autonomous neuropathy was diagnosed in the patients exhibiting deviation from the normal values in 3 of the five parameters of interest, viz. MWVR, QTc length, and three functional tests. Results. CAN at the subclincal stage was more frequently diagnosed in the adolescents with DM2 than in those suffering DM1 (29.2 and 10% of the cases respectively; p<0.05). This condition was not found in any of the patients presenting with endogenous constitutional obesity. MWVR in the adolescents with DM2 was lower than in the patients with DM1 (p=0.02) or ECO (p=0.04). The QTc duration was greater in the DM2 patients than in the adolescents of the same age presenting with ECO (p=0.02) and comparable with that in the patients suffering DM1 (p=0.3). In the adolescents with DM2, positive correlation between CAN, the duration of diabetes, the quality of its compensation, and the patient’s age was documented while the length of the QTc interval negatively correlated with these three variables. Moreover, the occurrence of CAN positively correlated with peripheral neuropathy. No relationship with the severity of insulin resistance was observed.

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Section: результаты и обсуждениеunclassified

The cardiovascular form of autonomous neuropathy in the adolescents with type 2 diabetes mellitus

Еремина¹,

Лаптев²,

Zilberman³

et al. 2014

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

show abstract

Arrhythmogenic effects of hypoglycemia in children and adolescents with type 1 diabetes mellitus

Лаптев

Никитич²,

Ryabykina

et al. 2013

Diabetes mellitus

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Aim. To determine the effects of hypoglycemia on the duration of QT interval, heart rate variability (HRV) and frequency of arrhythmic events, as well as to closer investigate the factors associated with the development of various heart rhythm disorders in children and adolescents with type 1 diabetes mellitus (T1DM). Materials and methods. The study included 150 children and adolescents with T1DM at the age of 6?18 years. All participants underwent Holter monitoring and continuous glucose monitoring (CGM) for 24 hours. QTc and HRV parameters (SDNN, RMSSD, SVVR) were calculated automatically. Data was averaged for 5?-interval and juxtaposed with CGM. Patients identified with hypoglycemic events (blood glucose

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Issledovanie intervala QT u detey i podrostkov, bol'nykh sakharnym diabetom 1 tipa, pri kholterovskom monitorirovanii EKG

Cited by 2 publications

References 13 publications

The cardiovascular form of autonomous neuropathy in the adolescents with type 2 diabetes mellitus

The cardiovascular form of autonomous neuropathy in the adolescents with type 2 diabetes mellitus

Arrhythmogenic effects of hypoglycemia in children and adolescents with type 1 diabetes mellitus

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