Isovaleric acid in stool correlates with human depression

Szczesniak, Olga; Hestad, Knut; Hanssen, Jon Fredrik; Rudi, Knut

doi:10.1179/1476830515y.0000000007

Cited by 124 publications

(79 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The V3 and V4 region of the 16S rRNA gene was amplified using forward primer PRK341 and reverse primer PRK806 [20], with further processing for Illumina sequencing as previously described [19]. Finally, quantification of butyric acid in cecum content was performed by GC [21]. Butyric acid was chosen as a biomarker because this is the most well-documented short-chain fatty acid to be protective against CRC [17].…”

Section: Methodsmentioning

confidence: 99%

Cecal microbiota association with tumor load in a colorectal cancer mouse model

Bråten

Södring

Paulsen

et al. 2017

Microbial Ecology in Health and Disease

Self Cite

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) is one of the most common cancer types worldwide. The role of the intestinal microbiota in CRC, however, is not well established. In particular, the co-variation between age, tumor progression and microbiota remains largely unknown.Objective and design: We therefore used a recently developed A/J Min/+ mouse model resembling human CRC to investigate how microbial composition in cecum correlates with tumor progression, butyrate and age.Results: We found that the association between the gut microbiota and tumor load was stronger, by far, than the association with both butyrate and age. The strongest direct tumor association was found for mucosal bacteria, with nearly 60% of the significantly correlating operational taxonomic units being correlated with CRC tumor load alone.Conclusion: We favor a systemic association between tumor load and microbiota, since the correlations are associated with tumor load in gut segments other than the cecum (both small and large intestine).

show abstract

Section: Methodsmentioning

confidence: 99%

Cecal microbiota association with tumor load in a colorectal cancer mouse model

Bråten

Södring

Paulsen

et al. 2017

Microbial Ecology in Health and Disease

Self Cite

View full text Add to dashboard Cite

show abstract

“…Szczesniak et al found that bacteria such as Faecalibacterium, Alistipes and Ruminococcus were correlated with depression, as well as the level of isovaleric acid, a type of volatile fatty acid (VFA) [112]. These associations probably occur because gut-derived VFAs can pass the BBB and further interact with synaptic neurotransmitters.…”

Section: Food and Food-derived Metabolitesmentioning

confidence: 99%

The progress of gut microbiome research related to brain disorders

Zhu

Jiang

et al. 2020

J Neuroinflammation

304

213

View full text Add to dashboard Cite

There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior. Cognition was originally thought to be regulated only by the central nervous system. However, it is now becoming clear that many non-nervous system factors, including the gut-resident bacteria of the gastrointestinal tract, regulate and influence cognitive dysfunction as well as the process of neurodegeneration and cerebrovascular diseases. Extrinsic and intrinsic factors including dietary habits can regulate the composition of the microbiota. Microbes release metabolites and microbiota-derived molecules to further trigger host-derived cytokines and inflammation in the central nervous system, which contribute greatly to the pathogenesis of host brain disorders such as pain, depression, anxiety, autism, Alzheimer's diseases, Parkinson's disease, and stroke. Change of blood-brain barrier permeability, brain vascular physiology, and brain structure are among the most critical causes of the development of downstream neurological dysfunction. In this review, we will discuss the following parts: Overview of technical approaches used in gut microbiome studies Microbiota and immunity Gut microbiota and metabolites Microbiota-induced blood-brain barrier dysfunction Neuropsychiatric diseases ■ Stress and depression ■ Pain and migraine ■ Autism spectrum disorders Neurodegenerative diseases ■ Parkinson's disease ■ Alzheimer's disease ■ Amyotrophic lateral sclerosis ■ Multiple sclerosis

show abstract

“…Regarding the gut microbiome’s influence on neurotransmitters, a recent study has shown that patients diagnosed with depression have increased volatile fatty acids such as isovaleric acid in their stool (Szczesniak, Hestad, Hanssen, & Rudi, 2015). Isovaleric acid can cross the blood-brain barrier (BBB) and affect neurotransmitter release in the CNS, thus possibly worsening this disorder.…”

Section: Biomarkers Of Interestmentioning

confidence: 99%

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

Ghaisas

Maher

Kanthasamy

2016

Pharmacology & Therapeutics

431

280

View full text Add to dashboard Cite

The gut microbiome comprises the collective genome of the trillions of microorganisms residing in our gastrointestinal ecosystem. The interaction between the host and its gut microbiome is a complex relationship whose manipulation could prove critical to preventing or treating not only various gut disorders, like irritable bowel syndrome (IBS) and ulcerative colitis (UC), but also central nervous system (CNS) disorders, such as Alzheimer’s and Parkinson’s diseases. The purpose of this review is to summarize what is known about the gut microbiome, how it is connected to the development of disease and to identify the bacterial and biochemical targets that should be the focus of future research. Understanding the mechanisms behind the activity and proliferation of the gut microbiome will provide us new insights that may pave the way for novel therapeutic strategies.

show abstract

Isovaleric acid in stool correlates with human depression

Cited by 124 publications

References 15 publications

Cecal microbiota association with tumor load in a colorectal cancer mouse model

Cecal microbiota association with tumor load in a colorectal cancer mouse model

The progress of gut microbiome research related to brain disorders

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

Contact Info

Product

Resources

About