Isotretinoín y depresión: ¿una realidad?

Serrano, Antonio Garrido; Rodríguez, Lourdes; Linares, M. Suárez; Muñoz, M; Pulpillo, A.; Conejo‐Mir, Julián

doi:10.1016/s0001-7310(03)76740-4

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…The incidence of depression in isotretinoin users is 0% in studies with a control group and 1–1.5% in studies without controls. These rates are similar to the incidence of depression in the general population, which is known to be about 1% 6–8 …”

Section: Introductionsupporting

confidence: 64%

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Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents

Kaymak¹,

Taner²,

Taner³

2008

Int J Dermatology

111

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Background Since the introduction of isotretinoin to the market, many adverse psychiatric effects, including depression, anxiety and suicide attempts were reported. The aim of this study was to determine whether patients with acne who were treated with isotretinoin experienced significant increases in psychiatric symptoms over a 4-month period compared with patients who received topical acne therapy.Methods Seventy-eight acne patients were allocated either to isotretinoin treatment (study group) (n = 37) or to topical treatment (control group) (n = 41). Their psychological status was evaluated at the baseline, second and fourth months of the treatment. All patients were required to complete the dermatology life quality index (DLQI), the Hospital anxiety and depression (HAD) scale, and the beck depression inventory (BDI). ResultsThe two groups were not different from each other in terms of DLQI, BDI, HAD-A, HAD-D and total HAD scores at baseline. However, at the end of the second month quality of life was more impaired in the topical treatment group compared to the isotretinoin group (P < 0.05), and there were no difference between two groups in terms of BDI, HAD-A, HAD-D, and total HAD scores (P > 0.05). At the end of fourth month quality of life and all psychological test scores had improved more in the isotretinoin group compared to topical treatment group (P < 0.05). ConclusionResults of the present study indicate that there is no increase in depressive and anxiety symptoms in the isotretinoin treatment group compared to that in the topical group.Instead, successful treatment of acne seems to improve both depressive and anxiety symptoms and improve quality of life. IntroductionIsotretinoin is a synthetic oral retinoid that has great efficacy against severe, recalcitrant, nodulocystic acne. Since its introduction to the market, many adverse psychiatric effects, including depression, psychosis, mood swings, violent behavior, suicide, and suicide attempts were reported. [1][2][3] Although some case reports and open label studies investigated the association of depression and isotretinoin treatment, results were conflicting. 4,5 The overall lack of concrete scientific data limits any conclusion that can be drawn about a causal relationship between isotretinoin and adverse psychiatric events. 6 The incidence of depression in isotretinoin users is 0% in studies with a control group and 1-1.5% in studies without controls. These rates are similar to the incidence of depression in the general population, which is known to be about 1%. [6][7][8] Depression is a multifactorial disorder, and both acne and psychiatric disorders, 9,10 often affect people in the 15-24 years age group. Eighty-five to 90% of adolescents and young adults have some degree of acne. The main goal of acne treatment is to prevent physical scarring by limiting the number of lesions and the duration of the disease, thereby minimizing its psychological impact. 11,12 The psychological impact of acne is well documented, particularly in adolesce...

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Section: Introductionsupporting

confidence: 64%

“…These rates are similar to the incidence of depression in the general population, which is known to be about 1%. [6][7][8] Depression is a multifactorial disorder, and both acne and psychiatric disorders, 9,10 often affect people in the 15-24 years age group. Eighty-five to 90% of adolescents and young adults have some degree of acne.…”

Section: Introductionmentioning

confidence: 99%

Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents

Kaymak¹,

Taner²,

Taner³

2008

Int J Dermatology

111

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“…In a third, depression was described in 10 of 94 patients (11%) . In some of the studies, no differences in depressive symptoms and signs emerged in comparisons between isotretinoin‐treated and control groups; some others described a significant improvement (see details in Table ). In addition, some studies have described a beneficial effect of isotretinoin on quality of life and psychosomatic or psychiatric conditions other than depression.…”

Section: Human Studiesmentioning

confidence: 99%

“…studies reporting more than 20 patients or other scientifically relevant information) are listed in Table , together with their most important features. The studies described in these 26 articles vary in terms of study design, number of patients, therapy regimen, and even in their definitions of depression. An association between isotretinoin therapy and depression was investigated in 23 publications.…”

Section: Human Studiesmentioning

confidence: 99%

Does isotretinoin therapy of acne cure or cause depression?

et al. 2013

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Cosmetic defects in acne may provoke a wide range of mental disorders (depressive, social-phobic, etc.). Isotretinoin is a very effective acne treatment; hence, it usually resolves the associated mental disorders. However, more available data show the possible association of taking isotretinoin and the onset of a depressive syndrome that includes frank depression and even suicidal ideation. The frequency of depressive disorders during isotretinoin treatment varies from 1% to 11% in different studies, and it is unclear whether this is a consequence of isotretinoin therapy. Since it crosses the blood-brain barrier, isotretinoin affects the expression of a broad spectrum of genes in the limbic structures, thus affecting the function of the dopaminergic, serotonergic, and noradrenergic neurons involved in the regulation of mood and emotion. It was suggested that isotretinoin in high concentrations inhibits hippocampal neurogenesis and induces apoptosis of hippocampal cells. However, some studies do not confirm this pathogenic role, and isotretinoin was even reported to have a therapeutic effect in acne-associated depression. In this review, we highlight epidemiological data, the underlying molecular pathogenesis, and the aspects of prevention concerning retinoid-induced depression in acne from the practical point of view of a dermatologist.

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Acne Vulgaris

Romano

Dellavalle

2014

Evidence‐Based Dermatology

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Isotretinoín y depresión: ¿una realidad?

Cited by 8 publications

References 17 publications

Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents

Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents

Does isotretinoin therapy of acne cure or cause depression?

Acne Vulgaris

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