Does isotretinoin therapy of acne cure or cause depression?

Borovaya, Alena; Olisova, Olga Yu.; Ruzicka, Thomas; Sárdy, Miklós

doi:10.1111/ijd.12169

Cited by 31 publications

(21 citation statements)

References 46 publications

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“…The use of isotretinoin has been frequently associated with depression and less frequently with suicide and psychosis [14]. Isotretinoin may disrupt the functions of several cerebral regions like hippocampus, corpus striatum, and frontal cortex, particularly the orbitofrontal cortex, which are associated with the pathophysiology of depression [15].…”

Section: Introductionmentioning

confidence: 99%

The association of depression, loneliness and internet addiction levels in patients with acne vulgaris

Öztekin

2020

BioPsychoSocial Med

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Background: Acne vulgaris is a very common skin disorder that has negative effects on the mood, self image and social relations of the patients. We want to evaluate the effects of acne vulgaris and its severity on depression, loneliness, internet addiction levels, and the quality of life of young adult females. Methods: Two hundred three female acne vulgaris patients and 202 healthy controls who admitted to the dermatology clinic of a university hospital formed the study sample. Global Acne Grading System (GAGS) was used to assess the severity of acne. The Young Internet Addiction Scale-Short Form (YIAS-SF), The Acne Quality of Life Scale (AQLS), The University of California Los Angeles-Loneliness Scale (UCLA-LS), and The Beck Depression Inventory (BDI) were used to collect information about the patients. Results: The median BDI and the mean UCLA-LS and YIAS-SF scores were higher in the Acne group than those in the control group. The correlations between acne severity and the 3 scales were not significant but the correlations between AQLS and BDI, UCLA-LS, and YIAS-SF were highly significant. In multiple regression analysis, age and the BDI score predicted the YIAS-SF score significantly. Conclusions: Our findings support the previous findings that acne vulgaris patients are prone to depression and loneliness, and expand these findings to the vulnerability against internet addiction. Loneliness and depression should be assessed and, if found, targeted by psychological means to prevent internet addiction in acne vulgaris patients.

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Section: Introductionmentioning

confidence: 99%

The association of depression, loneliness and internet addiction levels in patients with acne vulgaris

Öztekin

2020

BioPsychoSocial Med

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“…As expected, topic INN into the systemic circulation was high, with systemic exposure to INN being approximately 22 times higher than that in the epidermis [ 37 ]. It can across the blood-brain barrier easily and act in the brain tissue [ 38 ]. Since it crosses the blood-brain barrier, INN affects the expression of a wide spectrum of genes in the limbic structures, thus changing the function of the dopaminergic, serotonergic, noradrenergic neurons involved in the modulation of mood [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…It can across the blood-brain barrier easily and act in the brain tissue [ 38 ]. Since it crosses the blood-brain barrier, INN affects the expression of a wide spectrum of genes in the limbic structures, thus changing the function of the dopaminergic, serotonergic, noradrenergic neurons involved in the modulation of mood [ 38 ]. Our results also suggest that INN can induce depressive behavior ( Fig 3 ) , which is associated with the prevetion of hippocampal 5-HT-5-HT1A/1B system and induces apoptosis (Figs 4 and 5 ) .…”

Section: Discussionmentioning

confidence: 99%

Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice

Feng

et al. 2016

PLoS ONE

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Dermatosis often as a chronic disease requires effective long-term treatment; a comprehensive evaluation of mental health of dermatology drug does not receive enough attention. An interaction between dermatology and psychiatry has been increasingly described. Substantial evidence has accumulated that psychological stress can be associated with pigmentation, endocrine and immune systems in skin to create the optimal responses against pathogens and other physicochemical stressors to maintain or restore internal homeostasis. Additionally, given the common ectodermal origin shared by the brain and skin, we are interested in assessing how disruption of skin systems (pigmentary, endocrine and immune systems) may play a key role in brain functions. Thus, we selected three drugs (hydroquinone, isotretinoin, tacrolimus) with percutaneous excessive delivery to respectively intervene in these systems and then evaluate the potential neurotoxic effects. Firstly, C57BL/6 mice were administrated a dermal dose of hydroquinone cream, isotretinoin gel or tacrolimus ointment (2%, 0.05%, 0.1%, respectively, 5 times of the clinical dose). Behavioral testing was performed and levels of proteins were measured in the hippocampus. It was found that mice treated with isotretinoin or tacrolimus, presented a lower activity in open-field test and obvious depressive-like behavior in tail suspension test. Besides, they damaged cytoarchitecture, reduced the level of 5-HT-5-HT1A/1B system and increased the expression of apoptosis-related proteins in the hippocampus. To enable sensitive monitoring the dose-response characteristics of the consecutive neurobehavioral disorders, mice received gradient concentrations of hydroquinone (2%, 4%, 6%). Subsequently, hydroquinone induced behavioral disorders and hippocampal dysfunction in a dose-dependent response. When doses were high as 6% which was 3 times higher than 2% dose, then 100% of mice exhibited depressive-like behavior. Certainly, 6% hydroquinone exposure elicited the most serious impairment of hippocampal structure and survival. The fact that higher doses of hydroquinone are associated with a greater risk of depression is further indication that hydroquinone is responsible for the development of depression. These above data demonstrated that chronic administration of different dermatology drugs contributed into common mental distress. This surprising discovery of chemical stressors stimulating the hippocampal dysfunction, paves the way for exciting areas of study on the cross-talk between the skin and the brain, as well as is suggesting how to develop effective and safe usage of dermatological drugs in daily practice.

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“…Depressive disorders are more of a concern with interferon-α (especially interferon-α2b) than interferon-β (Raison 2005). Isotretinoin is known to be associated with depression, suicidal ideation and psychosis (Borovaya 2013). The frequency of depressive disorders during treatment with this drug varies from 1 to 11% in different studies, but it is unclear whether this is a consequence of isotretinoin therapy (Borovaya 2013).…”

Section: Important Drugs With Adverse Psychiatric Effectsmentioning

confidence: 99%

“…Isotretinoin is known to be associated with depression, suicidal ideation and psychosis (Borovaya 2013). The frequency of depressive disorders during treatment with this drug varies from 1 to 11% in different studies, but it is unclear whether this is a consequence of isotretinoin therapy (Borovaya 2013). The effect is not known to be related to dose or duration of treatment, or to previous psychiatric illness.…”

Section: Important Drugs With Adverse Psychiatric Effectsmentioning

confidence: 99%

Adverse psychiatric effects of non-psychotropic medications

Gupta

Chadda

2016

BJPsych advances

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SummaryPatients presenting to psychiatrists frequently have comorbid medical conditions for which they are receiving treatment. A range of medications used for treatment of these conditions can have adverse effects resembling psychiatric symptoms. This article presents the results of our review of the literature on psychiatric adverse effects of various non-psychotropic medications, and discusses the mechanisms of such effects, their assessment and management. Among the commonly prescribed drugs found to have psychiatric adverse effects are corticosteroids, anti-Parkinsonian drugs, anti-epileptics, antiretrovirals, antibiotics, anticancer drugs, analgesics, drugs targeting endocrine and cardiovascular disorders, immunosuppressants, skeletal muscle relaxants and bronchodilators. Some adverse effects are predictable and dose dependent, whereas others are rare and idiosyncratic, and psychiatrists need to be aware of them for accurate diagnosis and appropriate treatment.

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Does isotretinoin therapy of acne cure or cause depression?

Cited by 31 publications

References 46 publications

The association of depression, loneliness and internet addiction levels in patients with acne vulgaris

The association of depression, loneliness and internet addiction levels in patients with acne vulgaris

Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice

Adverse psychiatric effects of non-psychotropic medications

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