Isotopic ratio measurement of methane in ambient air using mid-infrared cavity leak-out spectroscopy

Dahnke, Hannes; Kleine, D.; Urban, W.; Hering, P.; Mürtz, Manfred

doi:10.1007/s003400000509

Cited by 50 publications

(28 citation statements)

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“…Laser spectroscopy-based techniques used in breath analysis include, but not limited to, the tunable diode laser absorption spectroscopy, 22,23 cavity ringdown spectroscopy (CRDS), [24][25][26][27] integrated cavity output spectroscopy, [28][29][30][31] cavity enhanced absorption spectroscopy, 32 cavity leak-out absorption spectroscopy, [33][34][35][36][37] photoacoustic spectroscopy, 38 quartz-enhanced photoacoustic spectroscopy, 39 and optical frequency comb cavity-enhanced absorption spectroscopy. 40,41 Although some of these techniques have been used for breath analysis in a lab-based experimental system or a prototype, none of them have been used to develop a commercial or close-to commercial breath instrument for clinical use, except for the lead-salt laser absorption instrument that has been used commercially for breath NO analysis.…”

Section: Introductionmentioning

confidence: 99%

A fully integrated standalone portable cavity ringdown breath acetone analyzer

Sun

Jiang

Gong

et al. 2015

Review of Scientific Instruments

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A laser-locked cavity ring-down spectrometer employing an analog detection scheme Review of Scientific Instruments 71, 347 (2000) Breath analysis is a promising new technique for nonintrusive disease diagnosis and metabolic status monitoring. One challenging issue in using a breath biomarker for potential particular disease screening is to find a quantitative relationship between the concentration of the breath biomarker and clinical diagnostic parameters of the specific disease. In order to address this issue, we need a new instrument that is capable of conducting real-time, online breath analysis with high data throughput, so that a large scale of clinical test (more subjects) can be achieved in a short period of time. In this work, we report a fully integrated, standalone, portable analyzer based on the cavity ringdown spectroscopy technique for near-real time, online breath acetone measurements. The performance of the portable analyzer in measurements of breath acetone was interrogated and validated by using the certificated gas chromatography-mass spectrometry. The results show that this new analyzer is useful for reliable online (online introduction of a breath sample without pretreatment) breath acetone analysis with high sensitivity (57 ppb) and high data throughput (one data per second). Subsequently, the validated breath analyzer was employed for acetone measurements in 119 human subjects under various situations. The instrument design, packaging, specifications, and future improvements were also described. From an optical ringdown cavity operated by the lab-set electronics reported previously to this fully integrated standalone new instrument, we have enabled a new scientific tool suited for large scales of breath acetone analysis and created an instrument platform that can even be adopted for study of other breath biomarkers by using different lasers and ringdown mirrors covering corresponding spectral fingerprints. C 2015 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.[http://dx

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Section: Introductionmentioning

confidence: 99%

A fully integrated standalone portable cavity ringdown breath acetone analyzer

Sun

Jiang

Gong

et al. 2015

Review of Scientific Instruments

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“…The cavity leak−out spectroscopy (CALOS) is a CW variant of CRDS [50][51][52]. After an optical excitation of the cavity, the laser power is turned off and the subsequent power decay of the radiation is observed by a photodetector.…”

Section: Cavity Ring-down Spectroscopymentioning

confidence: 99%

Ultrasensitive laser spectroscopy for breath analysis

Wojtas

Bielecki

Stacewicz

et al. 2012

Opto-Electronics Review

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At present there are many reasons for seeking new methods and technologies that aim to develop new and more perfect sensors for different chemical compounds. However, the main reasons are safety ensuring and health care. In the paper, recent advances in the human breath analysis by the use of different techniques are presented. We have selected non-invasive ones ensuring detection of pathogenic changes at a molecular level. The presence of certain molecules in the human breath is used as an indicator of a specific disease. Thus, the analysis of the human breath is very useful for health monitoring. We have shown some examples of diseases’ biomarkers and various methods capable of detecting them. Described methods have been divided into non-optical and optical methods. The former ones are the following: gas chromatography, flame ionization detection, mass spectrometry, ion mobility spectrometry, proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry. In recent twenty years, the optical methods have become more popular, especially the laser techniques. They have a great potential for detection and monitoring of the components in the gas phase. These methods are characterized by high sensitivity and good selectivity. The spectroscopic sensors provide the opportunity to detect specific gases and to measure their concentration either in a sampling place or a remote one. Multipass spectroscopy, cavity ring-down spectroscopy, and photo-acoustic spectroscopy were characterised in the paper as well.

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“…Kosterev et al 6 reported measurements of isotopic composition with a quantum-cascade laser that probes the 4 P branch of methane at 8.1 m (no measurement uncertainty was reported). Dahnke et al 7 reported a ␦…”

Section: Introductionmentioning

confidence: 99%

Stable isotopic analysis of atmospheric methane by infrared spectroscopy by use of diode laser difference-frequency generation

et al. 2006

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An infrared absorption spectrometer has been constructed to measure the stable isotopic composition of atmospheric methane samples. The spectrometer employs periodically poled lithium niobate to generate 15 W of tunable difference-frequency radiation from two near-infrared diode lasers that probe the 3 rotational-vibrational band of methane at 3.4 m. To enhance the signal, methane is extracted from 25 l of air by use of a cryogenic chromatographic column and is expanded into the multipass cell for analysis. A measurement precision of 12‰ is demonstrated for both ␦ 13 C and ␦D.

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Isotopic ratio measurement of methane in ambient air using mid-infrared cavity leak-out spectroscopy

Cited by 50 publications

References 0 publications

A fully integrated standalone portable cavity ringdown breath acetone analyzer

A fully integrated standalone portable cavity ringdown breath acetone analyzer

Ultrasensitive laser spectroscopy for breath analysis

Stable isotopic analysis of atmospheric methane by infrared spectroscopy by use of diode laser difference-frequency generation

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