Isotope metallomics approaches for medical research

Mahan, Brandon; Chung, Roger S.; Pountney, Dean L.; Moynier, Frédéric; Turner, Simon

doi:10.1007/s00018-020-03484-0

Cited by 21 publications

(11 citation statements)

References 119 publications

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“…Form of metal(loid) species : Some subgroups within metallomics can be distinguished based on the different natures of various metal species. Thus, studies devoted to the behaviour of different metal isotopes are defined as isotope metallomics [ 53 , 54 ]. The metabolism and behaviours of radioactive elements are related to radiometallomics [ 55 ].…”

Section: Metallomics As a Scientific Approachmentioning

confidence: 99%

Metallophenolomics: A Novel Integrated Approach to Study Complexation of Plant Phenolics with Metal/Metalloid Ions

Fedenko

Landi

Shemet³

2022

IJMS

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Plant adaptive strategies have been shaped during evolutionary development in the constant interaction with a plethora of environmental factors, including the presence of metals/metalloids in the environment. Among adaptive reactions against either the excess of trace elements or toxic doses of non-essential elements, their complexation with molecular endogenous ligands, including phenolics, has received increasing attention. Currently, the complexation of phenolics with metal(loid)s is a topic of intensive studies in different scientific fields. In spite of the numerous studies on their chelating capacity, the systemic analysis of phenolics as plant ligands has not been performed yet. Such a systematizing can be performed based on the modern approach of metallomics as an integral biometal science, which in turn has been differentiated into subgroups according to the nature of the bioligands. In this regard, the present review summarizes phenolics–metal(loid)s’ interactions using the metallomic approach. Experimental results on the chelating activity of representative compounds from different phenolic subgroups in vitro and in vivo are systematized. General properties of phenolic ligands and specific properties of anthocyanins are revealed. The novel concept of metallophenolomics is proposed, as a ligand-oriented subgroup of metallomics, which is an integrated approach to study phenolics–metal(loid)s’ complexations. The research subjects of metallophenolomics are outlined according to the methodology of metallomic studies, including mission-oriented biometal sciences (environmental sciences, food sciences and nutrition, medicine, cosmetology, coloration technologies, chemical sciences, material sciences, solar cell sciences). Metallophenolomics opens new prospects to unite multidisciplinary investigations of phenolic–metal(loid) interactions.

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Section: Metallomics As a Scientific Approachmentioning

confidence: 99%

Metallophenolomics: A Novel Integrated Approach to Study Complexation of Plant Phenolics with Metal/Metalloid Ions

Fedenko

Landi

Shemet³

2022

IJMS

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“…This also contributes to relatively high sample throughput and the ability to analyze a larger series of samples. MC-ICP-MS is widely used in geo- and cosmochemistry and has been demonstrated to be a valuable tool for revealing differences in the stable isotopic compositions of essential mineral elements, such as Cu, Fe, Zn, Mg, and Ca, between body compartments, and for signaling deviations in their homeostasis occurring in the case of disease. − …”

Section: Introductionmentioning

confidence: 99%

Robust Potassium Isotopic Analysis of Geological and Biological Samples via Multicollector ICP-Mass Spectrometry Using the “Extra-High Resolution Mode”

2021

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Potassium isotopic analysis is arousing increasing interest, not only in geochemistry, but also in biomedicine. However, real-life applications are still hindered by the lack of robustness of the methods used. In this work, a novel and robust method for high-precision K isotopic analysis of geological and biological samples was developed, based on the use of a multicollector ICP-mass spectrometer providing a mass resolving power of 15,000 (extra-high resolution mode, XHR). After evaluation of different measurement conditions, i.e., hot vs cold plasma conditions, standard-type vs jet-type sampling cone, and high resolution (HR) vs XHR, a combination of hot plasma conditions, use of the high-transmission jet-type sampling cone, and the XHR mode allowed for high-precision and interference-free K isotopic analysis. Potassium signal monitoring was performed in the ArH+ interference-free 0.006–0.007 amu wide peak shoulder using the XHR mode. The within-run, short-term external, and long-term external precisions for the δ41K value were 0.02‰ (2se, N = 50), 0.03‰ (2SD, N = 7), and 0.06‰ (2SD, N = 163), respectively. A two-stage chromatographic procedure was developed for the isolation of K from both geological and biological samples, and potential matrix effects affecting the K isotope ratio were systematically evaluated. The method was first applied to geological reference materials (RMs) for validation purposes, and the K isotope ratio results were in good agreement with those previously reported. Subsequently, a series of biological RMs, including serum, whole blood, cerebrospinal fluid, bovine muscle, and lobster hepatopancreas, were characterized for their K isotopic composition.

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“…Exploring the utility of metal isotopes in medical research is a relatively new endeavor, yet this field has already shown considerable promise in understanding underlying mechanisms of disease and in developing disease biomarkers. 6 , 15 , 16 , 42–48 The utility of metal isotopes in biological systems owes largely to the fact that isotopes generally fractionate due to: (i) changes in their bonding environments during exchange reactions (equilibrium isotope fractionation, e.g. healthy vs. diseased cells), where stronger bonds favor heavier isotopes 12 , 13 ; and/or (ii) (nonequilibrium) kinetic effects during dominantly unidirectional processes such as diffusion.…”

Section: Introductionmentioning

confidence: 99%

“… 49–51 What is important in terms of the scientific value—and predictive power—of isotope metallomics is that both equilibrium and nonequilibrium isotope fractionation can be well described and modelled through ab initio theoretical calculations, 52–55 allowing for mechanistic interpretations of empirical data. 15 In brief, for equilibrium isotope fractionation, the isotopic composition of a given bodily reservoir, especially in relation to others (e.g. blood relative to brain tissue), is beholden to bonding environment; for kinetic isotope fractionation, along a chain of chemical reactions (e.g.…”

Section: Introductionmentioning

confidence: 99%

Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease

et al. 2022

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Natural stable metal isotopes have shown utility in differentiation between healthy and diseased brain states (e.g. Alzheimer's disease, AD). While the AD brain accumulates some metals, it purges others, namely K (accompanied by increased serum K, suggesting brain-blood transferal). Here, K isotope compositions of Göttingen minipig brain regions for two AD models at mid-life are reported. Results indicate heavy K isotope enrichment where amyloid beta (Aβ) accumulation is observed, and this enrichment correlates with relative K depletion. These results suggest preferential efflux of isotopically light K + from the brain, a linkage between brain K concentrations and isotope compositions, and linkage to Aβ (previously shown to purge cellular brain K+). Brain K isotope compositions differ from that for serum and brain K is much more abundant than in serum, suggesting that changes in brain K may transfer a measurable K isotope excursion to serum, thereby generating an early AD biomarker.

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Isotope metallomics approaches for medical research

Cited by 21 publications

References 119 publications

Metallophenolomics: A Novel Integrated Approach to Study Complexation of Plant Phenolics with Metal/Metalloid Ions

Metallophenolomics: A Novel Integrated Approach to Study Complexation of Plant Phenolics with Metal/Metalloid Ions

Robust Potassium Isotopic Analysis of Geological and Biological Samples via Multicollector ICP-Mass Spectrometry Using the “Extra-High Resolution Mode”

Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease

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