Isotope dilution gas chromatography - mass spectrometry for the development of certified reference material of ethyl carbamate in hydroalcoholic matrix

Vicentim, Marcos Paulo; Monteiro, Tânia; Almeida, Renato Rubim Ribeiro de; Soares, Anna Dandara Amorim; Rodrigues, Janaína Marques; Rego, Eliane Cristina Pires do

doi:10.1016/j.microc.2019.03.021

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…With no EC standard reference material available, it is difficult to ensure analytical consistency across laboratories. However, some institutions are working to produce a reference material (193). Availability of a reference material becomes increasingly important as laboratories shift from using traditional GC-MS to other methodologies, such as LC-MS or FI-MS.…”

Section: Discussionmentioning

confidence: 99%

“…Alternative methods to be discussed include flow-injection MS (FI-MS), enzymelinked immunosorbent assay (ELISA), infrared (IR) spectroscopy, surface-enhanced Raman spectroscopy (SERS), and nanosensors. Although some efforts have been made to produce a commercial reference material for EC analysis, no such material is currently available (193).…”

Section: Analytical Methods For Determination Of Ec Concentrations In...mentioning

confidence: 99%

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Occurrence of Ethyl Carbamate in Foods and Beverages: Review of the Formation Mechanisms, Advances in Analytical Methods, and Mitigation Strategies

Abt

Incorvati

Robin

et al. 2021

Journal of Food Protection

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Ethyl carbamate (EC) is a process contaminant that can be formed as a byproduct during fermentation and processing of foods and beverages. Elevated EC levels are primarily associated with distilled spirits, but this compound has also been found at lower levels in foods and beverages, including breads, soy sauce, and wine. Evidence from animal studies suggests that EC is a probable human carcinogen. Consequently, several governmental institutions have established allowable limits for EC in the food supply. This review will discuss EC formation mechanisms, occurrence of EC in the food supply, and EC dietary exposure assessments. Analytical methods currently used to detect EC, and advances in experimental technologies, such as nanosensors and surface-enhanced Raman spectroscopy (SERS) will also be discussed. Finally, application of mitigation methods to maintain levels of EC under allowable limits will be covered, including distillation practices, enzymatic treatments, and genetic engineering of yeast. Ongoing research in this field is needed to refine mitigation strategies and develop methods to rapidly detect EC in the food supply.

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Section: Discussionmentioning

confidence: 99%

Section: Analytical Methods For Determination Of Ec Concentrations In...mentioning

confidence: 99%

Occurrence of Ethyl Carbamate in Foods and Beverages: Review of the Formation Mechanisms, Advances in Analytical Methods, and Mitigation Strategies

Abt

Incorvati

Robin

et al. 2021

Journal of Food Protection

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“…Certified reference material (CRM) is a measurement standard that performs an important function in the comparability and consistency of measurement data, and is an essential phase and the material guarantee of analysis and detection work, including the verification of laboratory quality control test and analysis technique [21][22][23][24]. Matrix CRMs are usually selected to be similar to the test sample in real state, and the value was accurately characterized [25].…”

Section: Introductionmentioning

confidence: 99%

Study of novel matrix certified reference material for accurate measurement of AFM1 in milk powder with two different concentrations

Huang,

Liu,

Zhou

et al. 2023

Preprint

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In this study, two different concentrations of matrix certified reference materials (CRMs) were produced for the accurate measurement of aflatoxin M1(AFM1) in milk powder((GBW(E) 100552, GBW(E) 100553)). The raw material was obtained by feeding cows with positive drugs. The homogeneity, stability and characterization of this matrix CRMs were examined by liquid chromatography tandem mass spectrometry with isotope-labeled internal standard method. The certified value for the low concentration of AFM1 in milk powder was 2.45 µg/kg with an uncertainty of 0.43 µg/kg (coverage factor k = 2, at 95% confidence). The certified value for the high concentration of AFM1 in milk powder was 3.45 µg/kg with an expanded uncertainty of 0.49 µg/kg (coverage factor k = 2, at 95% confidence). In addition, the samples were evaluated in detail for homogeneity, long-term stability at -80°C for 6 months, and short-term stability at 4°C for 7 days. The results showed that the samples were stable under the above conditions.

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Certification of a novel matrix reference material for accurate measurements of aflatoxin M1 in milk powder

Huang,

Liu,

Zhou

et al. 2024

Accred Qual Assur

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Isotope dilution gas chromatography - mass spectrometry for the development of certified reference material of ethyl carbamate in hydroalcoholic matrix

Cited by 5 publications

References 6 publications

Occurrence of Ethyl Carbamate in Foods and Beverages: Review of the Formation Mechanisms, Advances in Analytical Methods, and Mitigation Strategies

Occurrence of Ethyl Carbamate in Foods and Beverages: Review of the Formation Mechanisms, Advances in Analytical Methods, and Mitigation Strategies

Study of novel matrix certified reference material for accurate measurement of AFM1 in milk powder with two different concentrations

Certification of a novel matrix reference material for accurate measurements of aflatoxin M1 in milk powder

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