“…It is well recognized that the thiazolo[3,2- a ]pyrimidine; a fused heterocyclic system consisting of six-membered pyrimidine and five-membered thiazole rings with bridgehead nitrogen atom is a privileged motif found in numerous natural products and various synthetic compounds. In the recent times, it has emerged as a potential synthetic area in heterocyclic synthesis due to its widespread applications among as acetylcholinesterase inhibitor 1 , calcium antagonist 2 , cytotoxic agent 3 , antitubercular, CDC25 phosphatase inhibitor 4 , antidepressant 5 as well as in polymerization reactions as co-polymer 6 – 8 . Although short of literature, the synthesis of thiazolo[3,2- a ]pyrimidine nucleus has been reported by the sodium acetate catalyzed reaction of tetrahydropyrimidine-5( H )-2-thione with α-halo carbonyl compounds 1 , 5 , 9 in acetic acid reflux, 1,1,1,3,4,4,5,5,5-nonafluoro-2-(trifluoromethyl)pent-2-ene 10 in triethylamine catalyzed acetonitrile reflux and by the reaction of aromatic aldehydes with 2-aminothiazole and malononitrile/diethyl malonate/ethyl 2-cyanoacetate in piperidine catalyzed ethanolic reflux 11 , 12 .…”