Synthesis, Antifungal, and Antioxidant Evaluation of New Class of Thiazolo[3,2-a]pyrimidine and Pyrimido[5,4-d]thiazolo[3,2-a]pyrimidine Derived from α,α-Ketene Dithioacetals as Five and Six-membered Heterocycles Analogues

Moharam, Marwa Mostafa; Saleh, Ebraheem Abdu Musad; Hassan, Ismail; Husain, Kakul

doi:10.1134/s1068162023050199

Russ J Bioorg Chem

2023

DOI: 10.1134/s1068162023050199

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Synthesis, Antifungal, and Antioxidant Evaluation of New Class of Thiazolo[3,2-a]pyrimidine and Pyrimido[5,4-d]thiazolo[3,2-a]pyrimidine Derived from α,α-Ketene Dithioacetals as Five and Six-membered Heterocycles Analogues

Marwa Mostafa Moharam,

Ebraheem Abdu Musad Saleh,

Ismail Hassan

et al.

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2024

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Cited by 2 publications

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A Robust In Vitro Anti‐tuberculosis, Antimicrobial, and Anti‐inflammatory Activities Based on Azomethine Chelates Incorporating Co(II), Ni (II), Cu(II), and Zn(II) Ions: Synthesis, Characterization, and Investigation of the Aspects of Docking Interaction

Rani,

Devi,

Kumar

et al. 2024

Applied Organom Chemis

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In recent times, there has been a growing exploration of transition metal complexes as potential solutions for significant health challenges, including tuberculosis, microbes infection, and inflammation. Therefore, in our ongoing effort to identify biologically effective agents, Co(II), Ni(II), Cu(II), and Zn(II) metal complexes of H2L1–H2L2 hydrazone ligands were synthesized. The structural features of synthesized compounds were recognized by employing several techniques such as FT‐IR, 1H NMR, 13C NMR, powder x‐ray diffraction (XRD), UV‐Vis, ESR, TG‐DTA, mass spectrometry, and molar conductance measurements. The bonding of ligands via Ophenolic, Oenolic, and Nazomethine donor atoms and the attachment of the three water molecules with metal ion to form the octahedral structure of complexes were corroborated by different spectroscopic techniques. The anti‐tuberculosis, antimicrobial, and anti‐inflammatory activities of the synthesized compounds were assessed using the microplate alamar blue assay, serial dilution, and bovine serum albumin (BSA) methods, respectively, and highlighted the more potency of the complexes than ligands. The synthesized Cu(II) (9) and Zn(II) (10) metal complexes exhibited excellent ability to inhibit the growth of H37Rv strain of Mycobacterium tuberculosis in comparison to standard drug streptomycin. The Cu(II) (6 and 9) and Zn(II) (10) complexes showed superb ability as antimicrobial agents, whereas Cu(II) (5) and Zn(II) (6) complexes exhibited significant anti‐inflammatory ability. The in vitro findings on the antituberculosis activity were reinforced by a significant molecular docking study, which has become a crucial component of computational research utilizing the enzyme Mtb Pks13 thioesterase domain of M. tuberculosis. Additionally, in this research work, the absorption–distribution–metabolism–excretion–toxicity (ADMET) study sparked the compounds' drug‐like behavior.

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A Robust In Vitro Anti‐tuberculosis, Antimicrobial, and Anti‐inflammatory Activities Based on Azomethine Chelates Incorporating Co(II), Ni (II), Cu(II), and Zn(II) Ions: Synthesis, Characterization, and Investigation of the Aspects of Docking Interaction

Rani,

Devi,

Kumar

et al. 2024

Applied Organom Chemis

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Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects

Venugopala,

Kamat

2024

Pharmaceuticals

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Pyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of synthesis, easily available precursor, and less duration for the reaction, for the synthesis, not many technical skills are needed. All these factors attract chemists to focus more on pyrimidines. Apart from the synthesis of biological applications of pyrimidines, medicinal chemists have gathered to explore more pyrimidine scaffolds due to their interesting medicinal properties and easy targeting of various binding sites. This review delves into the diverse biological activities of compounds derived from pyrimidine during the year 2024. We have attempted to explore the growing significance of pyrimidine derivatives and provide a new path for designing new potent molecules.

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Synthesis, Antifungal, and Antioxidant Evaluation of New Class of Thiazolo[3,2-a]pyrimidine and Pyrimido[5,4-d]thiazolo[3,2-a]pyrimidine Derived from α,α-Ketene Dithioacetals as Five and Six-membered Heterocycles Analogues

Cited by 2 publications

References 42 publications

A Robust In Vitro Anti‐tuberculosis, Antimicrobial, and Anti‐inflammatory Activities Based on Azomethine Chelates Incorporating Co(II), Ni (II), Cu(II), and Zn(II) Ions: Synthesis, Characterization, and Investigation of the Aspects of Docking Interaction

A Robust In Vitro Anti‐tuberculosis, Antimicrobial, and Anti‐inflammatory Activities Based on Azomethine Chelates Incorporating Co(II), Ni (II), Cu(II), and Zn(II) Ions: Synthesis, Characterization, and Investigation of the Aspects of Docking Interaction

Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects

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