Isoquinoline alkaloids induce partial protection of laying hens from the impact of Campylobacter hepaticus (spotty liver disease) challenge

Quinteros, José A.; Scott, Peter C.; Wilson, Timothy B.; Anwar, Arif; Scott, Tyrone; Muralidharan, Chithralekha; Van, Thi Thu Hao; Moore, Robert J.

doi:10.1016/j.psj.2021.101423

Cited by 13 publications

(14 citation statements)

References 48 publications

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“…Though not reported in RCC, flavonols (kaempferol, fisetin and myricetin) play a role in reducing risks for advanced prostate cancer but show no effect on bladder cancer susceptibility [ 89 ]. Interestingly, fisetin, as well as chelerythrine are also reported to be important supplements for poultry to avoid heat stress-associated morbidities and spotty liver disease, respectively [ 90 , 91 ]. Lastly, animal studies on Lycium barbarum polysaccharides, osthole and thymoquinone have also shown satisfactory tolerability in vivo and those products hold promise to the manufacture of relevant supplements [ 92 , 93 , 94 ].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

et al. 2022

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Renal cell carcinoma (RCC) is a common cancer of the urinary system. The potential therapeutic effects of certain natural products against renal cell carcinoma have been reported both in vivo and in vitro, but no reviews have been published classifying and summarizing the mechanisms of action of various natural products. In this study, we used PubMed and Google Scholar to collect and screen the recent literature on natural products with anti-renal-cancer effects. The main mechanisms of action of these products include the induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis and reduction of drug resistance. In total, we examined more than 30 natural products, which include kahweol acetate, honokiol, englerin A and epigallocatechin-3-gallate, among others, have demonstrated a variety of anti-renal-cancer effects. In conclusion, natural products may have a wider application in kidney cancer than previously believed and are potential candidates for treatment in RCC.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

et al. 2022

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“…Nevertheless, gut microbiota composition in hens is not only determined by feedingbased strategies, but can also be a consequence of their behavior and allocation conditions, as reported by Van de Eijk for luminal microbiota (combined content of ileum, ceca, and colon) in high-feather-pecking laying hens that differentiate from low-feather peckers by a higher relative abundance of bacteria genera related to Clostridiales, but lower incidence of Lactobacillus and Staphylococcus, although it not yet elucidated if these differences are causal or a consequence of feather pecking [50]. Another commonly observed conditioning factor is the incidence of infectious agents in the flock, so it is important to highlight the protective effect that phytobiotics may provide, such as the observed in Campylobacter hepaticus-challenged hens supplemented with Isoquinoline alkaloids [50]. Results of that study showed that after 4 weeks of supplementation with isoquinoline alkaloids, hens exposed to C. hepaticus HV10 showed less miliary lesions on the liver surface and lower lesion scores in comparison with exposed but not-supplemented hens with the phytobiotic.…”

Section: Discussionmentioning

confidence: 99%

Allium-Based Phytobiotic for Laying Hens’ Supplementation: Effects on Productivity, Egg Quality, and Fecal Microbiota

et al. 2022

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The poultry industry is constantly demanding novel strategies to improve the productivity and health status of hens, prioritizing those based on the holistic use of natural resources. This study aimed to assess the effects of an Allium-based phytobiotic on productivity, egg quality, and fecal microbiota of laying hens. One hundred and ninety-two 14-week-old Lohmann Lite LSL hens were allocated into an experimental farm, fed with a commercial concentrate with and without the Allium-based phytobiotic, and challenged against Salmonella. Productivity, egg quality, and fecal microbiota were monitored for 20 weeks. Results showed that the phytobiotic caused an increase on the number of eggs laid (p < 0.05) and in the feed conversion rate (p < 0.05); meanwhile, egg quality, expressed as egg weight, albumin height, haugh units, egg shell strength, and egg shell thickness remained unchanged (p > 0.05), although yolk color was decreased. Fecal microbiota structure was also modified, indicating a modulation of the gut microbiota by increasing the presence of Firmicutes and Bacteroidetes but reducing Proteobacteria and Actinobacteria phyla. Predicted changes in the functional profiles of fecal microbiota suggest alterations in metabolic activities that could be responsible for the improvement and maintenance of productivity and egg quality when the phytobiotic was supplemented; thus, Allium-based phytobiotic has a major impact on the performance of laying hens associated with a possible gut microbiota modulation.

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“…Zhang et al ( 19 ) investigated the antibacterial activity and mechanism of SG against Providencia rettgeri and showed that SG could exhibit inhibitory effects on its biofilm formation and disrupt the integrity and permeability of the cell membrane. Moreover, Quinteros et al ( 20 ) showed that SG could effectively inhibit the growth of Campylobacter hepaticus (spotty liver disease) and significantly reduce the proinflammatory cytokines in the blood of infected hens. Hu et al ( 21 ) found that SG had obvious inhibitory and inactivating effects on Candida albicans in vivo and in vitro .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity and mechanism of sanguinarine against Staphylococcus aureus by interfering with the permeability of the cell wall and membrane and inducing bacterial ROS production

Dong²,

Li³

et al. 2023

Front. Vet. Sci.

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Staphylococcus aureus (SA) is representative of gram-positive bacteria. Sanguinarine chloride hydrate (SGCH) is the hydrochloride form of sanguinarine (SG), one of the main extracts of Macleaya cordata (M. cordata). There are few reports on its antibacterial mechanism against SA. Therefore, in this study, we investigated the in vitro antibacterial activity and mechanism of SGCH against SA. The inhibitory zone, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were measured, and the bactericidal activity curve was plotted. In addition, the micromorphology, alkaline phosphatase (AKP) activity, Na+K+, Ca2+Mg2+-adenosine triphosphate (ATP) activity, intracellular reactive oxygen species (ROS), and fluorescein diacetate (FDA) were observed and detected. The results showed that the inhibitory zone of SGCH against SA was judged as medium-sensitive; the MIC and MBC were 128 and 256 μg/mL, respectively; in the bactericidal activity curve, SGCH with 8 × MIC could completely kill SA within 24 h. SGCH was able to interfere with the integrity and permeability of the SA cell wall and membrane, as confirmed by the scanning electron microscopy (SEM) images, the increase in extracellular AKP and Na+ K+, Ca2+ Mg2+-ATP activities as well as the fluorescein diacetate (FDA) staining experiment results. Moreover, a high concentration of SGCH could induce SA to produce large amounts of ROS. In summary, these findings revealed that SGCH has a preferable antibacterial effect on SA, providing an experimental and theoretical basis for using SG as an antibiotic substitute in animal husbandry and for the clinical control and treatment of diseases caused by SA.

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Isoquinoline alkaloids induce partial protection of laying hens from the impact of Campylobacter hepaticus (spotty liver disease) challenge

Cited by 13 publications

References 48 publications

Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

Allium-Based Phytobiotic for Laying Hens’ Supplementation: Effects on Productivity, Egg Quality, and Fecal Microbiota

Antibacterial activity and mechanism of sanguinarine against Staphylococcus aureus by interfering with the permeability of the cell wall and membrane and inducing bacterial ROS production

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