Isoquinoline alkaloids from Hylomecon japonica and their potential anti-breast cancer activities

Cao, Zhen; Zhu, Shuang; Xue, Zhaowei; Zhang, Fuxin; Zhang, Lei; Guo, Yuting; Zhan, Guanqun; Zhang, Xinxin; Guo, Zengjun

doi:10.1016/j.phytochem.2022.113321

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…Cao et al investigated the anticancer effects of 13 isoquinoline alkaloids extracted from Hylomecon japonica on MCF-7 breast cancer cells. Among these 13 alkaloids, 6,10-dimethoxydihydrochelerythrine, 6S/R-acroleinyl-dihydrochelerythrine, 9-methoxy-10-hydroxy-norchelerythrine, 10-methoxy boconoline, 6-methoxydihydrosanguinarine, dihydrosanguinaline, and 6-acetaldehyde-dihydrochelerythrine exhibited a significant inhibitory potential with an IC 50 of ˂20 μM on MCF-7 cells [ 102 ]. Freeling et al determined the tumor suppression potential of the plant-based alkaloid veratridine (VTD).…”

Section: Plant-derived Bioactive Compounds As Anti-cancerous Agentsmentioning

confidence: 99%

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs

Asma

Acaröz

Imre

et al. 2022

Cancers

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Cancer is one of the major deadly diseases globally. The alarming rise in the mortality rate due to this disease attracks attention towards discovering potent anticancer agents to overcome its mortality rate. The discovery of novel and effective anticancer agents from natural sources has been the main point of interest in pharmaceutical research because of attractive natural therapeutic agents with an immense chemical diversity in species of animals, plants, and microorganisms. More than 60% of contemporary anticancer drugs, in one form or another, have originated from natural sources. Plants and microbial species are chosen based on their composition, ecology, phytochemical, and ethnopharmacological properties. Plants and their derivatives have played a significant role in producing effective anticancer agents. Some plant derivatives include vincristine, vinblastine, irinotecan, topotecan, etoposide, podophyllotoxin, and paclitaxel. Based on their particular activity, a number of other plant-derived bioactive compounds are in the clinical development phase against cancer, such as gimatecan, elomotecan, etc. Additionally, the conjugation of natural compounds with anti-cancerous drugs, or some polymeric carriers particularly targeted to epitopes on the site of interest to tumors, can generate effective targeted treatment therapies. Cognizance from such pharmaceutical research studies would yield alternative drug development strategies through natural sources which could be economical, more reliable, and safe to use.

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Section: Plant-derived Bioactive Compounds As Anti-cancerous Agentsmentioning

confidence: 99%