Isoprenoid-substituted phenolic compounds of moraceous plants

Nomura, Taro; Hano, Yoshio

doi:10.1039/np9941100205

Cited by 95 publications

(97 citation statements)

References 78 publications

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“…As folhas dessas espécies são consumidas no Japão e Coréia como agentes antihiperglicêmicos por pacientes com diabetes mellitus, devido à presença da 1-desoxinojirimicina, que é conhecida como um dos mais potentes inibidores da á-glicosidase (Kim et al, 2003). Este gênero contém uma variedade de compostos fenólicos, incluindo flavonoides isoprenilados, estilbenos, 2-arilbenzopiranos, cumarinas, cromonas, xantonas e uma variedade de compostos de Diels-Alder (Nomura et al, 1988;Nomura & Hano, 1994). Alguns desses compostos exibem propriedades biológicas interessantes tais como efeito antiflogístico, antiinflamatório, diurético, hipotensor, e alguns são também conhecidos como fitoalexinas (Syah et al, 2000).…”

Section: Introductionunclassified

Avaliação toxicológica pré-clínica do chá das folhas de Morus nigra L. (Moraceae)

Oliveira

Guimarães

et al. 2013

Rev. bras. plantas med.

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RESUMO:O objetivo desse estudo foi realizar um ensaio toxicológico pré-clínico para analisar a toxicidade do chá das folhas de Morus nigra L. (Moraceae). A toxicidade subcrônica do chá (CFMn) foi avaliada durante 30 dias por via oral em ratos. Ao grupo controle foi administrado água, para comparação. Durante o período experimental foi avaliada a presença de sinais de toxicidade, variação do peso corporal, e o consumo de líquido e alimento. Ao final do experimento o sangue dos animais foi retirado para análise de parâmetros hematológicos e bioquímicos. Não foram observados mortalidade e sinais de toxicidade indicando baixa toxicidade da planta. Não houve alterações nos parâmetros hematológicos e bioquímicos. Nas condições do estudo, o CF-Mn pode ser considerado de baixa toxicidade, pois não produziu efeitos tóxicos nos animais tratados. . The subchronic toxicity of this tea (CF-Mn) was orally evaluated during 30 days in rats. The control group was given water for comparison. During the experimental period, signs of toxicity, body weight variation, and water and food consumption were assessed. At the end of the experiment, the blood of animals was removed for analysis of hematological and biochemical parameters. No mortality and no toxicity signs were observed, indicating low toxicity of the plant. There was no alteration in the hematological and biochemical parameters. Under the study conditions, CF-Mn can be considered of low toxicity since it did not produce toxic effects in treated animals. Palavras

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Section: Introductionunclassified

Avaliação toxicológica pré-clínica do chá das folhas de Morus nigra L. (Moraceae)

Oliveira

Guimarães

et al. 2013

Rev. bras. plantas med.

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“…Morus nigra has been used in folk medicine as an analgesic, diuretic, antitussive, sedative, anxiolytic and hypotensive, in addition to its uses in the treatment of a variety of ailments, including inflammatory disorders [17]. There are few studies involving the chemical composition and evaluation of biological and pharmacological properties of Morus nigra.…”

Section: Morus Nigra Lmentioning

confidence: 99%

“…The leaves of mulberry species are consumed in Korea and Japan as anti-hyperglycemic nutraceutical food for patients with diabetes mellitus because the leaves are rich in alkaloid components, including 1-deoxynojirymicin (1), which is known to be one of the most potentglycosidase inhibitors [16] that decreases blood sugar levels. This genus contains a variety of phenolic compounds including isoprenylated flavonoids, stilbenes, 2-arylbenzopyrans, coumarins, chromones, xanthones and a variety of Diels-Alder adduct compounds [14,17]. Some of these compounds exhibit interesting biological properties such as antiphlogistic, antiinflammatory, diuretic, hypotensive effects and some are known as phytoalexins [18].…”

Section: The Family Moraceae and The Genus Morusmentioning

confidence: 99%

Medicinal Plants and Natural Compounds from the Genus Morus (Moraceae) with Hypoglycemic Activity: A Review

Almeida¹,

Souza²,

Araújo³

et al. 2012

Glucose Tolerance

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“…The mulberry belongs to the genus Morus of the family Moraceae (ALMEIDA et al, 2011) and has been widely used in folk medicine as hepatoprotective, hypotensive, antipyretic, analgesic, diuretic, expectorant and antidiabetic (NOMURA, 1988;CHEN et al, 1995). Several compounds have been isolated from the roots, trunk bark and leaves of M. nigra, such as the piperidine alkaloid (moranoline), glycoproteins and phenolic compounds (flavonoids, stilbenes, coumarins) (NOMURA; HANO, 1994;KIM et al, 1999;TOSHIO et al, 2005;MAZIMBA et al, 2011). Some of these compounds (for example, flavonoids) have antioxidant properties, reducing oxidative stress, reactive oxygen species (ROS) levels, lipid peroxidation and DNA damage in different cell types (MAZIMBA et al, 2011;VOLPATO et al, 2011;MATA-CAMPUZANO et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effect of ovarian tissue storage in Morus nigra extract on the morphology and DNA fragmentation of ovine preantral follicles

Cavalcante

Barberino

Gouveia

et al. 2017

SCA

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This study demonstrated the effect of Morus nigra leaf extract during ovine ovarian tissue transportation on the survival and apoptosis of preantral follicles in vitro. High Performance Liquid Chromatography (HPLC) was used to determine the fingerprint chromatogram of the crude ethanolic extract. Four pairs of ovaries from four sheep were collected. The ovarian cortex was fragmented and one fragment was fixed in 10% buffered formaldehyde and processed for histological and TUNEL analyses (fresh control). The other fragments were placed in Minimal Essential Medium (MEM -control medium) or M. nigra extract (0.025; 0.05 or 0.1 mg/mL) and stored (simulating transport) at 4ºC for 6, 12 or 24 h. Preserved fragments (6 h) were also destined to histological and TUNEL analyses. HPLC analysis confirmed the presence of antioxidant compounds (rutin, isoquercetin e kaempferitrin) in the extract. There was a decrease (P < 0.05) in the percentage of morphologically normal preantral follicles after preservation in all treatments compared to the fresh control. The percentage of normal preantral follicles after preservation in M. nigra at 0.05 mg/mL for 6 h was higher (P < 0.05) than in MEM or 0.025 mg/ mL M. nigra and similar (P > 0.05) to 0.1 mg/mL of the extract. Apoptosis increased (P < 0.05) after conservation for 6 h in all treatments compared to the fresh control. Moreover, TUNEL positive cells decreased (P < 0.05) after preservation in 0.05 or 0.1 mg/mL M. nigra compared to MEM or 0.025 mg/ mL M. nigra. In conclusion, 0.05 mg/mL M. nigra extract can be used as a preservation medium for ovine ovarian tissue at 4°C for up to 6 h. ResumoEste estudo demonstrou o efeito do extrato das folhas de Morus nigra durante o transporte na sobrevivência e apoptose de folículos pré-antrais in vitro. A CLAE (Cromatografia Líquida de Alta Eficiência) foi usada para determinar a impressão digital cromatográfica do extrato etanólico. Foram coletados 4 pares de ovários de 4 ovelhas. O córtex ovariano foi fragmentado e um dos fragmentos foi fixado em formaldeído tamponado a 10% e destinado às análises histológica e de TUNEL (controle fresco). Os demais fragmentos foram colocados em Meio Essencial Mínimo (MEM -meio controle) ou extrato de M. nigra (0,025, 0,05 ou 0,1 mg/mL) e conservados (simulando transporte) à 4 ºC por 6, 12 ou 24 h. Os fragmentos conservados (6 h) também foram destinados às análises histológica e de TUNEL. A análise de CLAE confirmou a presença de compostos antioxidantes (rutina, isoquercetina e canferitrina) no extrato. Houve uma redução (P < 0,05) na percentagem de folículos pré-antrais morfologicamente normais após conservação em todos os tratamentos em comparação com o controle fresco. A percentagem de folículos pré-antrais normais após conservação em M. nigra a 0,05 mg/mL por 6 h foi maior (P < 0,05) do que em MEM ou M. nigra a 0,025 mg/mL e similar (P > 0,05) ao extrato a 0,1 mg/mL. A apoptose aumentou (P < 0,05) após conservação durante 6 h em todos os tratamentos em comparação com o controle fresco. Além diss...

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Isoprenoid-substituted phenolic compounds of moraceous plants

Cited by 95 publications

References 78 publications

Avaliação toxicológica pré-clínica do chá das folhas de Morus nigra L. (Moraceae)

Avaliação toxicológica pré-clínica do chá das folhas de Morus nigra L. (Moraceae)

Medicinal Plants and Natural Compounds from the Genus Morus (Moraceae) with Hypoglycemic Activity: A Review

Effect of ovarian tissue storage in Morus nigra extract on the morphology and DNA fragmentation of ovine preantral follicles

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