Isopathic Use of Auto-Sarcode of DNA as Anti-Miasmatic Homeopathic Medicine and Modulator of Gene Expression?

Teixeira, Marcus Zulian

doi:10.1055/s-0038-1676810

Cited by 10 publications

(34 citation statements)

References 50 publications

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“…In homeopathy, one investigator recently proposed using an individual's own homeopathically prepared DNA (which is inherently nano-scale), in their unique current epigenetic state of gene expression isopathically to treat miasmatic diseases. 151 Separately, mainstream nano-medicine researchers are already beginning to consider the therapeutic potential of different personalized protein corona coatings on quantitatively higher dose nano-structures. 135,136,143 For most clinical scenarios, however, the simillimum for the patient's current state would still be the single correctly chosen homeopathic medicine whose information resonates with and literally adsorbs onto its surface the most relevant pattern of endogenous proteins reflecting the patient's current state: that is, the biological information pattern of the recipient individual in the protein corona.…”

Section: Homeopathic Medicines As Complex Systemsmentioning

confidence: 99%

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

Bell

2019

Homeopathy

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Background Evidence indicates that homeopathic medicines are complex self-organizing nano-scale systems that generate unique low-intensity electromagnetic signals and/or quantum coherence domains. In Part 1, we reviewed relevant concepts from complex adaptive systems science on living systems for the nature of homeopathic healing. Aim In Part 2, we discuss the complex-system nature of homeopathic medicines. The aim is to relate the evidence on the nature and properties of homeopathic medicines to the complex systems model for homeopathic healing. Methods and Results The work is a narrative review, with complexity model development for the nature of homeopathic medicines. Studies suggest that homeopathic manufacturing generates nano-structures of source material, silica and silicon quantum dots if succussed in glassware or including botanical source materials; or carbon quantum dots if succussed in plastic or including any organic source materials, as well as solute-induced water nano-structures carrying medicine-specific information. On contact with physiological fluids (e.g., blood plasma), there is evidence that nano-structures additionally adsorb individualized patterns of the recipient's own proteins on to their surfaces to create a unique protein corona coat (shell). Thus, the simillimum may generate a personalized biological identity upon administration. Consequently, a medicine can serve as an individually salient, self-similar information carrier, whose protein corona constituent pattern reflects the individual's current internal state of health/disease. Homeopathic medicine complexity emerges from interactions of the component parts from source, silica from glassware or carbon from plastic containers, solvents (lactose, water, ethanol), adsorbed biomolecule layers from plant or animal sources, and adsorbed biomolecules of the recipient. Low doses of these complex medicines can act as biological signaling agents to initiate hormesis via a network-wide pattern of adaptive responses by the recipient complex adaptive system, rather than as conventional pharmaceutical drugs. Biological mediators of adaptive responses include inter-connected network elements of the cell danger/damage defense system: for example, gene expression, reactive oxygen species, heat shock proteins, cytokines, macrophages, T-cells, and associated brain–immune system mediator pathways. Conclusions Every homeopathic medicine is a complex nano-scale system involving multiple inter-connected, interacting components, and emergent properties. Simillimum individualization derives from formation of a unique personalized protein corona shell adsorbed to the reactive surface of the homeopathic nano-structures on contact with the recipient's body fluids. Low doses of such complex nano-structures initiate the adaptive processes of hormesis to mobilize endogenous healing of a disease state. The capacity for self-organization and self-similarity in complex systems is the key to future research on the nature of homeopathic medicines and systemic healing during individualized homeopathic treatment.

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Section: Homeopathic Medicines As Complex Systemsmentioning

confidence: 99%

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

Bell

2019

Homeopathy

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“…238 Then, a possible mechanism of action focuses on genetic material, since experimentation in this field shows that homeopathic medicines produce gene expression. 239,240 Furthermore, the existence of nanoparticles in the ultradilutions 241 allows to establish a physical connection between drugs and cellular response. However, there are nanoparticles within the quantum dots size range 242 and the identification of electromagnetic waves in DNA ultradilutions [243][244][245] and homeopathic preparations 246 points to an energetic effect that goes beyond matter.…”

Section: Sectionmentioning

confidence: 99%

“…In this unpublished article, a correlation has been seen between Silicea terra and iNOS, Arsenicum album and DAO, Argentum nitricum and the sodium-glucose transport protein type 1 (SGLT1), Veratrum album and the serotonin transporter (SERT), and Lycopodium clavatum and serotonin (5-HT). The symptoms of these drugs can be explained from the inhibition, blockade or functional deficiency of said protein products, and the genes that encode them could be the specific place of action of each homeopathic remedy to regulate them (there are various studies that support these statement 239,240 ). As it has already been mentioned, it must be verified.…”

Section: Sectionmentioning

confidence: 99%

The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement

Macías¹

2020

Homœopathic Links

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The new pandemic disease COVID-19 has wreaked havoc worldwide. Its infectious agent, SARS-CoV-2, uses two key human enzymes called angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) to invade body cells. The first one is encoded by the ACE2 gene and the second by the TMPRSS2 gene. Both have an outstanding expression of RNA and proteins in the small intestine compared with other tissues. This prominent location may be related to the main entry route of SARS-CoV-2 into the organism. In the process of infection, two other genes can play a fundamental role: NOS2, which expresses inducible nitric oxide synthase (iNOS), and AOC1, which encodes diamine oxidase (DAO). Both also highlight in the small intestine and are involved in polyamine metabolism. These biogenic amines are important for viral replication, being enhanced when NOS2 and AOC1 genes are downregulated. In addition, NOS2 shows a negative correlation with ACE2 and TMPRSS2, while nondegraded histamine by DAO can lead to an upregulation of both genes on which the virus depends. Taken together, these data suggest that inhibition or underexpression of NOS2 and AOC1 determines the susceptibility to get sick, increasing the risk of infection. On the other hand, a therapeutic approach to the disease could be made with homeopathic medicines. Experiments show the remedies' ability to stimulate gene and protein expression, but a correlation between the symptoms of each drug and these expressions has not yet been established. Here an analysis of the pathogenesis of Silicea terra and Arsenicum album supported on the scientific literature is done. The objective is to propose a theory about their relationship with key genes whose protein expressed in deficiency can give rise to the chain of events that imbalance the internal environment (homeostasis) and allow the development of symptoms. Silicea seems to be related to NOS2 (gene)/iNOS (protein) and Arsenicum with AOC1 (gene)/DAO (protein), being necessary to carry out studies to corroborate these links. Therefore, the aim of this article is to show the importance of NOS2 and AOC1 genes in the development of COVID-19 and to propose a line of investigation to evaluate if homeopathy can improve their protein expression.

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“…In this context, dozens of experiments show that potentised homeopathic medicines act at the gene regulatory level according to three main types of effects: change in the expression pattern of many genes; cytotoxicity or apoptosis in cancer cells; therapeutic modification in gene expression. 47 As implicated by the homeopathic vitalist concept, homeopathic medicines can be seen to restore the body's state of health because they modulate vital principle dystonia. By inferring that homeopathic medicines restore the body's state of health by modulating gene expression dystonia, the above experimental studies support the hypothetical correlation between genome (exome plus epigenome) and organic vital force.…”

Section: Correlation Between Vitalism and Genetics According To The Pmentioning

confidence: 99%

Correlation between Vitalism and Genetics According to the Paradigm of Complexity

Teixeira

2019

Homeopathy

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Background In homeopathic philosophy, vital force is a non-material substrate that is responsible for maintaining the body's sensations and functions and where homeopathic medicines act. In genetics, the body's vital functions are controlled by biochemical information, which is contained in the cell genome and consists of a protein encoding portion (exome) and another that regulates this encoding scheme (epigenome). Both the philosophical vital force and the genome present properties of complex and dynamic self-organisation systems. Aims This study aimed to explore and develop a philosophical-scientific correlation between vitalism and genetics according to the complexity paradigm. Results Vital principle and genome present inseparable composition among distinct existing components that influence one another and form a network of connections that create complex and dynamic self-organisation behaviour. Described in both models, ‘vortex’ indicates the existence of a force coming from within the system that is externalised as an emergent, information-transmitting phenomenon. Supporting this correlation, some experimental studies show that homeopathic medicines act on the genome by modulating gene expression. Conclusions In line with the similarity of existing characteristics and properties, the genome may be considered as hypothetical biological substrate of organic vital force.

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Isopathic Use of Auto-Sarcode of DNA as Anti-Miasmatic Homeopathic Medicine and Modulator of Gene Expression?

Cited by 10 publications

References 50 publications

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

The Complexity of the Homeopathic Healing Response Part 2: The Role of the Homeopathic Simillimum as a Complex System in Initiating Recovery from Disease

The Intestinal Perspective of COVID-19: NOS2 and AOC1 Genes as Epidemiological Factors, and a Homeopathic Approach to their Functional Improvement

Correlation between Vitalism and Genetics According to the Paradigm of Complexity

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