1997
DOI: 10.1016/s0002-9149(97)00096-9
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Isometric Handgrip Exercise Increases Endothelin-1 Plasma Levels in Patients With Chronic Congestive Heart Failure

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Cited by 14 publications
(8 citation statements)
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References 23 publications
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“…There are few data showing increases in circulating vasoconstrictor hormones during static exercise, but they have been obtained in subjects varying in age and health status. It was demonstrated, therefore, that static handgrip caused an increase in plasma vasopressin in healthy young men (Nazar et al 1989), and endothelin-1 in hypertensive patients (Cottone et al 1998), young normotensive offspring of hypertensive parents (Mangieri et al 1998) and patients with congestive heart failure (Mangieri et al 1997). On the other hand, we have recently demonstrated that static handgrip caused also an increase in the plasma adrenomedullin (ADM), which is a potent vasorelaxant probably involved in the fine blood pressure control counteracting the effect of vasoconstrictors.…”
Section: Introductionmentioning
confidence: 99%
“…There are few data showing increases in circulating vasoconstrictor hormones during static exercise, but they have been obtained in subjects varying in age and health status. It was demonstrated, therefore, that static handgrip caused an increase in plasma vasopressin in healthy young men (Nazar et al 1989), and endothelin-1 in hypertensive patients (Cottone et al 1998), young normotensive offspring of hypertensive parents (Mangieri et al 1998) and patients with congestive heart failure (Mangieri et al 1997). On the other hand, we have recently demonstrated that static handgrip caused also an increase in the plasma adrenomedullin (ADM), which is a potent vasorelaxant probably involved in the fine blood pressure control counteracting the effect of vasoconstrictors.…”
Section: Introductionmentioning
confidence: 99%
“…Increase in plasma ET-1 observed in athletes during physical exercise and in patients with chronic congestive heart failure during isometric exercise was reported [3,4], demonstrating that endothelin release rises during changes of vascular stress induced by physical exercise.…”
Section: Introductionmentioning
confidence: 93%
“…ET-1 has been evaluated in humans and its plasma levels of ET-1 were high in patients with CHF, correlated with the degree of pulmo-nary hypertension (99), and exercise impairment (100,101). ET-1 and its precursor were related to both the magnitude of alterations in cardiac hemodynamics and functional class severity of CHF and to the patient's prognosis (102,103).…”
Section: Endothelinsmentioning
confidence: 99%