Isometric Handgrip Exercise Increases Endothelin-1 Plasma Levels in Patients With Chronic Congestive Heart Failure

Madon, E; Tanzilli, Gaetano; Barillà, Francesco; Ciavolella, Massimo; Serafini, Gianluca; Nardi, Marcello Schiavo; Mangiaracina, Francesco; Scibilia, G; Dell’Italia, Louis J.; Campa, Pietro Paolo

doi:10.1016/s0002-9149(97)00096-9

Cited by 14 publications

(8 citation statements)

References 23 publications

(15 reference statements)

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“…There are few data showing increases in circulating vasoconstrictor hormones during static exercise, but they have been obtained in subjects varying in age and health status. It was demonstrated, therefore, that static handgrip caused an increase in plasma vasopressin in healthy young men (Nazar et al 1989), and endothelin-1 in hypertensive patients (Cottone et al 1998), young normotensive offspring of hypertensive parents (Mangieri et al 1998) and patients with congestive heart failure (Mangieri et al 1997). On the other hand, we have recently demonstrated that static handgrip caused also an increase in the plasma adrenomedullin (ADM), which is a potent vasorelaxant probably involved in the fine blood pressure control counteracting the effect of vasoconstrictors.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

et al. 2011

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The purpose of this study was to investigate the effect of age on cardiovascular changes and plasma concentrations of adrenomedullin (ADM), catecholamines, endothelin-1 (ET-1) and plasma renin activity (PRA) in healthy men. A total of 15 young (21 ± 0.3 years) and 15 older (64 ± 0.7 years) healthy men performed two 3-min bouts of static handgrip at 30% of maximal voluntary contraction, alternately with each hand without any break between the bouts. During exercise heart rate (HR), blood pressure (BP), stroke volume (SV) and pre-ejection period (PEP) and left ventricle ejection time (LVET) were measured. Blood samples were taken before exercise, at the end of both exercise bouts and in the fifth minute of the recovery period. The handgrip-induced increases in HR and cardiac output were significantly smaller in older than in young men (p < 0.01). SV decreased only in older men (p < 0.001). There were no differences between groups in BP increases. The baseline plasma ADM and catecholamines were higher in older man compared to young subjects. Handgrip caused increases in plasma ADM, ET-1 and PRA only in older men (p < 0.05). The increases in plasma ADM correlated positively with those of noradrenaline (NA), PRA, ET-1 and LVET and negatively with changes in total peripheral resistance (TPR), SV, PEP and PEP/LVET ratio. The increases in plasma ET-1 correlated positively with those of NA, PRA, TPR, mean BP and SV. These results revealed that ADM, ET-1 and angiotensin II can contribute to maintain vascular tone during static exercise in older but not in younger men.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

et al. 2011

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“…Increase in plasma ET-1 observed in athletes during physical exercise and in patients with chronic congestive heart failure during isometric exercise was reported [3,4], demonstrating that endothelin release rises during changes of vascular stress induced by physical exercise.…”

Section: Introductionmentioning

confidence: 93%

Influence of Vascular Load on Plasma Endothelin-1, Cytokines and Catecholamine Levels in Essential Hypertensives

COTTONE

1998

Blood Pressure

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In vitro studies demonstrated a relationship between ET-1 and basic Fibroblast Growth Factor (bFGF), and of bFGF with Platelet Derived Growth Factor (PDGF). The present study was carried out to investigate in vivo the behaviour after vascular stress of circulating ET-1, bFGF and PDGF, and catecholamines, and their relationship. In 12 healthy normotensives (NTs) and 15 essential hypertensives (Ehs) venous blood samples to determine circulating ET-1, bFGF and PDGF, and catecholamine (EPI and NE) levels were drawn before and at the third minute of a handgrip test. Blood pressures (BP) and heart rate were automatically recorded before starting, and at 1, 2, and 3 minutes during the test. The NTs showed, in basal condition, lower values than the EHs of all the examined parameters; later, the handgrip test induced significant increases in circulating levels of ET-1, bFGF and catecholamine. In the EHs at the third minute of the exercise significant increases in plasma ET-1 (p < 0.002), bFGF (p < 0.006), and EPI and NE (p < 0.0005) levels were observed. Systolic and diastolic BP significantly increased after handgrip test in NTs and EHs. Plasma ET-1 correlated with bFGF both before (p < 0.01) and at the acme (p < 0.05) of the isometric exercise. Our results show that in EHs plasma ET-1 and bFGF correlate each other, indicating that in human hypertension a linkage between ET-1 and bFGF exists.

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“…ET-1 has been evaluated in humans and its plasma levels of ET-1 were high in patients with CHF, correlated with the degree of pulmo-nary hypertension (99), and exercise impairment (100,101). ET-1 and its precursor were related to both the magnitude of alterations in cardiac hemodynamics and functional class severity of CHF and to the patient's prognosis (102,103).…”

Section: Endothelinsmentioning

confidence: 99%

Chronic Heart Failure and the Immune System

Mari

Berardino

Cugno

2002

CRIAI

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Several lines of evidence support a role of immune mechanisms in the pathogenesis of chronic heart failure (CHF). Proinflammatory cytokines (interleukin-1, -2, -6, and tumor necrosis factor) and chemokines are involved in cardiac depression and in the progression of heart failure. Other components believed to be relevant to the pathogenesis of CHF are adhesion molecules, autoantibodies, nitric oxide (NO), and endothelin-1. The origin of the immune activation in patients with CHF is still unknown, however two hypotheses have been proposed on the basis of experimental and clinical data. One suggests that the bowel wall edema leads to bacterial translocation with subsequent endotoxin release and immune activation. The second suggests that the heart in CHF is the main source of cytokines, as is shown by the fact that TNFα is produced by the failing myocardium but not by a normal one. No single source of cytokine production (gut or heart) seems sufficient to fully explain the multiple organ involvement and the systemic inflammation of CHF, which is probably related to systemic hypoxia, a potent stimulus for activation of the immune system and for cytokine production. The effort to define the immune system's role has opened new perspectives of therapeutic strategies, such as anti-cytokine drugs, to treat CHF.

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Isometric Handgrip Exercise Increases Endothelin-1 Plasma Levels in Patients With Chronic Congestive Heart Failure

Cited by 14 publications

References 23 publications

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

Cardiovascular and hormonal responses to static handgrip in young and older healthy men

Influence of Vascular Load on Plasma Endothelin-1, Cytokines and Catecholamine Levels in Essential Hypertensives

Chronic Heart Failure and the Immune System

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