Isomeric Polycyclic Polyprenylated Acylphloroglucinols from the Bark of Mesua ferrea (Clusiaceae)

Abstract

Five new isomeric polycyclic polyprenylated acylphloroglucinols (PPAPs) named mesuaferroic acid A, B, C, E and F (1-5) were isolated from ethyl acetate extract of Mesua ferrea L. (Clusiaceae). The isomeric compounds were obtained after extensive chromatographic procedures mainly using preparative HPLC. Structures were established after detailed spectroscopic analysis mostly by 2D NMR techniques. Compounds 4 and 5 exhibited good α-glucosidase inhibitory activity with IC 50 values of 0.43 and 0.60 mM, respectively, comparing to the positive control, 1-deoxynojirimycin (IC 50 0.63 mM).

Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers

“…The seeds are used as an aromatic and a wound healer, while the flowers are used as expectorant, carminative, cordial and blood tonic agents in traditional Thai medicine [14,15]. This plant species showed a wide range of various phytochemical constituents, including coumarins, xanthones, triterpenoids, anthraquinones and flavonoids [16][17][18][19][20]. The plant has shown various pharmacological activities including anti-oxidant, anti-spasmodic, anti-inflammatory, anti-cancer, anti-ulcer, anti-diabetic, antiarthritic, anti-microbial, anti-venom, anti-convulsant, anti-hemorrhoid, central nervous system depressant, α-amylase inhibitory, immunomodulatory and hormone balancing, hepatoprotective, analgesic, and diuretic activities [21][22][23].…”