Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-κB in RAW 264.7 macrophages

Kim, Jiyeon; Park, Seung Jae; Yun, Kyung-Jin; Cho, Young-Wuk; Park, Hee-Juhn; Lee, Kyung‐Tae

doi:10.1016/j.ejphar.2008.01.032

Cited by 250 publications

(172 citation statements)

References 41 publications

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“…In the present study we found that treatment of fermented licorice extract (FLEx) with HaCaT keratinocytes suppressed UVB-induced reduction of cell viability and production of inflammatory mediators. Kim et al [11] reported that isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis reduced the LPS-induced expressions of inducible nitric oxide synthase (iNOS), COX-2, and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) at the protein and mRNA levels in a dose-dependent manner in macrophages. They also suggested that flavonoid glycosides are possibly due to their different affinities for cellular membranes because affinity for cellular membranes appears to play an important role in the cellular uptake of lipophilic compounds by passive diffusion and because isoliquiritin possesses a sugar moiety, which would reduce its lipophilicity and compatibility with cellular membranes.…”

Section: Effect Of Fermented Licorice Extract On Uvbirradiated Hacat mentioning

confidence: 99%

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Production of Flavonoid Compounds and Anti-inflammatory Property of Fermented Licorice Extract with the Basidiomycete Grifola frondosa HB0071

Bae¹,

Song²,

Kim³

et al. 2012

Journal of the Society of Cosmetic Scientists of Korea

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Liquiritigenin and isoliquiritigenin are the major flavonoids present in licorice. These flavonoid compounds were prepared by submerged culture of Grifola frondosa (G. frondosa) HB0071 mycelia producing β-glucosidase in the aqueous extract of licorice. The contents of liquiritigenin and isoliquiritigenin were increased during the fermentation. This fungus produced a high β-glucosidase (activity of 91.5 mU/mL), thereby achieving high amounts of liquiritigenin and isoliquiritigenin (568.5 µg/mL and 89.6 µg/mL), respectively at 96 h. A reversed-phase high-performance liquid chromatography method was established for simultaneous determination of liquiritigenin and isoliquiritigenin in fermented licorice extract (FLEx). The anti-inflammatory activities were investigated by licorice extract (LEx) before and after fermentation with G. frondosa HB0071. The treatment of UVB-irradiated HaCaT keratinocytes with FLEx resulted in a dose-dependent decrease in the expression level of cyclooxygenase-2 (COX-2) mRNA. Furthermore, FLEx dose-dependently decreased mRNA of the pro-inflammatory cytokines of IL-1β and IL-6 in UVB-irradiated HaCaT cells. These results suggest that FLEx may mitigate the effects of skin inflammation by reducing UVB-induced adverse skin reactions.

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Section: Effect Of Fermented Licorice Extract On Uvbirradiated Hacat mentioning

confidence: 99%

“…Kim et al [11] reported that isoliquiritigenin-isolated licorice extract effectively inhibited lipopolysaccharide (LPS)-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions and iNOS, COX-2, TNF-α, and IL-6 transcriptions in RAW 264.7 macrophages.…”

Section: Introductionmentioning

confidence: 99%

Production of Flavonoid Compounds and Anti-inflammatory Property of Fermented Licorice Extract with the Basidiomycete Grifola frondosa HB0071

Bae¹,

Song²,

Kim³

et al. 2012

Journal of the Society of Cosmetic Scientists of Korea

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“…A possible explanation is that the reduced lipophilicity caused by the sugar moiety complicates cellular uptake of the compound by passive diffusion through the cell membrane [70,127].…”

Section: Structure-activity Relationshipmentioning

confidence: 99%

“…Kim et al [70] reported that the anti-inflammatory properties of isoliquiritigenin (2) are mediated by downregulation of iNOS, COX-2, TNF-a, and IL-6. These proteins were downregulated by inhibition of NF-jB via suppression of IKK, ERK1/2 and reduction in p38 phosphorylation.…”

Section: Inflammation Cell-signaling Pathways Targeted By Chalconesmentioning

confidence: 99%

Dietary chalcones with chemopreventive and chemotherapeutic potential

et al. 2011

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Chalcones are absorbed in the daily diet and appear to be promising cancer chemopreventive agents. Chalcones represent an important group of the polyphenolic family, which includes a large number of naturally occurring molecules. This family possesses an interesting spectrum of biological activities, including antioxidative, antibacterial, anti-inflammatory, anticancer, cytotoxic, and immunosuppressive potential. Compounds of this family have been shown to interfere with each step of carcinogenesis, including initiation, promotion and progression. Moreover, numerous compounds from the family of dietary chalcones appear to show activity against cancer cells, suggesting that these molecules or their derivatives may be considered as potential anticancer drugs. This review will focus primarily on prominent members of the chalcone family with an 1,3-diphenyl-2-propenon core structure. Specifically, the inhibitory effects of these compounds on the different steps of carcinogenesis that reveal interesting chemopreventive and chemotherapeutic potential will be discussed.

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“…P. ginseng extract have been reported to be the potent free radical scavenger and antiinflammatory agents. Anti-inflammatory and antioxidant properties of these extracts are caused by iNOS, COX-2, TNF-a and IL-6 downregulation due to NF-kB inhibition (Cheng et al, 2008;Kim et al, 2008;Lee et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of ginseng total saponins against hepatic ischemia/reperfusion injury in experimental obstructive jaundice rats

Chen

Zhou

et al. 2013

Pharmaceutical Biology

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Context: Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is one of the most extensively used herbs for stroke and chronic debilitating conditions in East Asian countries. Ginsenosides (GS) are the main bioactive compounds for ginseng's efficacy, but the mechanisms have not been fully clarified. Objective: To investigate hepatoprotective effects of GS against ischemia/reperfusion (IR) injury in the experimental obstructive jaundice rats. Materials and methods: GS was fed to cholestatic rats with IR injury daily for 6 d at a dose of 1.10 g/kg. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD) and malondialdehyde (MDA) were determined by colorimetric method. Apoptosis was measured quantitatively by the terminal transferase UTP nick end-labeling method. Protein expression of Bax and Bcl-2 was detected by immunohistochemistry. Results and discussion: After intervention of GS to cholestatic rats with IR injury, the levels of activating blood flow were significantly improved, and the levels of serum ALT were decreased 1.7-times, AST decreased 1.3-times, but SOD activities were increased 1.1-times compared with those of the model rats. It could also reverse histopathological changes and inhibit IR-induced apoptosis of hepatic tissues via decrease of Bax/Bcl-2 ratio (from 2.87 AE 0.57 to 1.65 AE 0.29). Oral administration of GS in a dosage of 26.4 g/kg did not lead to toxic effects in rats. Conclusion: GS attenuated the IR injury in the presence of cholestasis and could be considered for the clinical treatment of cholestasis.

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Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-κB in RAW 264.7 macrophages

Cited by 250 publications

References 41 publications

Production of Flavonoid Compounds and Anti-inflammatory Property of Fermented Licorice Extract with the Basidiomycete Grifola frondosa HB0071

Production of Flavonoid Compounds and Anti-inflammatory Property of Fermented Licorice Extract with the Basidiomycete Grifola frondosa HB0071

Dietary chalcones with chemopreventive and chemotherapeutic potential

Protective effects of ginseng total saponins against hepatic ischemia/reperfusion injury in experimental obstructive jaundice rats

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