Isolinderalactone sensitizes oxaliplatin-resistance colorectal cancer cells through JNK/p38 MAPK signaling pathways

Kwak, Ah-Won; Park, Jin Woo; Lee, Seung-On; Lee, Jin Young; Seo, Jeong‐Meen; Yoon, Goo; Lee, Mee-Hyun; Choi, Joon-Seok; Shim, Jung‐Hyun

doi:10.1016/j.phymed.2022.154383

Cited by 20 publications

(19 citation statements)

References 42 publications

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“…And the expression levels of X-linked inhibitors of apoptosis and survivin in glioma cells were suppressed after treatment with ILL ( 30 ). It also demonstrated anti-tumor activity on CRC cells by inhibiting human CRC cell proliferation, inducing endoplasmic reticulum stress, modulating the G2/M phase of cell cycle progression, and inducing reactive oxygen species-mediated apoptosis through c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinases (MAPK) ( 31 ).…”

Section: Pharmacologymentioning

confidence: 99%

“…Besides that, eudesmanes exhibit liver protection (3,8) (13), anti-cancer (18, 19) (15), anti-fibrotic (1,14) (9), and anti-inflammatory properties (11,12) (14); lindenanes exhibit anti-inflammatory properties (36,37) and anti-oxidant activity (23) (20,27); germacranes (53,54) (13) exhibit liver protection activity. Furthermore, in elemanes, the representative compound isolinderalactone (ILL) (70) has significant anti-tumor activity (28)(29)(30)(31). And compound 83 shows anti-inflammatory properties (16).…”

Section: Sesquiterpenoidsmentioning

confidence: 99%

“…Among them, argemexirine (20) is the first time to be isolated from Lauraceae (41). Apart from this, the only β-carboline alkaloid (31) found in LA-R displays significant potential against the superoxide anion generation (43).…”

Section: Alkaloidsmentioning

confidence: 99%

“…Approximately 32 flavonoids and their glycosides have been isolated and identified (seen in Table 3 and Figure 3). The structural types include 27 flavonols (1-27), 3 flavanones (28-30), a flavone (31), and a dihydrochalcone (32) (4,7,18,(44)(45)(46)(47)(48). Among these, quercetin-3-O-β-D-glucoside (4), quercetin-3-O-β-D-arabinofuranoside (5), quercetin-3-O-α-L-rhamnopyranoside (QI) (6), quercetin-5-O-β-D-glucoside (9), kaempferol-7-O-α-Lrhamnopyranoside (24) were isolated and prepared by highspeed countercurrent chromatography (47).…”

Section: Flavonoidsmentioning

confidence: 99%

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A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Zou²,

Zhang³

et al. 2023

Front. Nutr.

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Lindera aggregata (Sims) Kosterm. (L. aggregata), which belongs to the genus Lindera in the family Lauraceae, is widely distributed in Asia and the temperate, tropical regions of North America. Its roots and leaves have been used for thousands of years as traditional Chinese medicine and/or functional food. To further explore its underlying nutritional value, this review provided a comprehensive insight into chemical constituents and pharmacological effects on L. aggregata. The phytochemical investigation of different parts of L. aggregata led to the identification of up to 349 components belonging to sesquiterpenoids, alkaloids, flavonoids, essential oils, and other compounds. Among them, sesquiterpenoids, flavonoids, and alkaloids are assessed as representative active ingredients of L. aggregata. A wide variety of pharmacological effects of L. aggregata, such as anti-hyperlipidemic, anti-tumor, anti-inflammatory, analgesic, and anti-oxidant, have been proved in vitro and in vivo. In summary, this review aims to provide a scientific basis and reference for further research and utilization of L. aggregata and lay the foundation for developing functional foods with potential active ingredients for the prevention and management of related diseases.

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Section: Pharmacologymentioning

confidence: 99%

Section: Sesquiterpenoidsmentioning

confidence: 99%

Section: Alkaloidsmentioning

confidence: 99%

Section: Flavonoidsmentioning

confidence: 99%

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A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Zou²,

Zhang³

et al. 2023

Front. Nutr.

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“…Furthermore, accumulating evidence suggests that epithelial-mesenchymal transition (EMT)[ 14 ] and DNA damage repair[ 15 ] are driving factors that result in chemoresistance and tumor progression. Many studies have reported that various signaling pathways, such as the TGF-β/Smad[ 16 ], JNK/p38 MAPK[ 17 ], Wnt/β-catenin[ 18 ], and MEK/ERK/ELK1[ 19 ] pathways are closely associated with oxaliplatin resistance. As the main regulatory components of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs)[ 20 ] and tumor-associated macrophages[ 21 ] can modulate cancer chemotherapy resistance through complex mechanisms of crosstalk.…”

Section: Introductionmentioning

confidence: 99%

Emerging roles of non-coding RNAs in colorectal cancer oxaliplatin resistance and liquid biopsy potential

Luo¹,

Wang²,

Zhao³

et al. 2023

World J Gastroenterol

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Colorectal cancer (CRC) is one of the most common malignancies of the digestive tract, with the annual incidence and mortality increasing consistently. Oxaliplatin-based chemotherapy is a preferred therapeutic regimen for patients with advanced CRC. However, most patients will inevitably develop resistance to oxaliplatin. Many studies have reported that non-coding RNAs (ncRNAs), such as microRNAs, long non-coding RNAs, and circular RNAs, are extensively involved in cancer progression. Moreover, emerging evidence has revealed that ncRNAs mediate chemoresistance to oxaliplatin by transcriptional and post-transcriptional regulation, and by epigenetic modification. In this review, we summarize the mechanisms by which ncRNAs regulate the initiation and development of CRC chemoresistance to oxaliplatin. Furthermore, we investigate the clinical application of ncRNAs as promising biomarkers for liquid CRC biopsy. This review provides new insights into overcoming oxaliplatin resistance in CRC by targeting ncRNAs.

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DUSP1 Promotes Osimertinib Drug-Tolerant Persistence by Inhibiting MAPK/ERK Signaling in Non-small Cell Lung Cancer

He,

Liu,

Lei

et al. 2024

Mol Biotechnol

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Isolinderalactone sensitizes oxaliplatin-resistance colorectal cancer cells through JNK/p38 MAPK signaling pathways

Cited by 20 publications

References 42 publications

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Emerging roles of non-coding RNAs in colorectal cancer oxaliplatin resistance and liquid biopsy potential

DUSP1 Promotes Osimertinib Drug-Tolerant Persistence by Inhibiting MAPK/ERK Signaling in Non-small Cell Lung Cancer

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