Isolierung, Konstitution und Synthese eines neuen Steroides aus Nebennieren. Über Steroide, 155. Mitteilung

Abstract

A new crystalline substance has been isolated from hog adrenals in a yield of about 30 mg per 1000 kg glands. It appears to act under certain biological conditions as a sodium excreting factor. This compound is shown to be 3β,16α‐dihydroxy‐allopregnan‐20‐one; several syntheses of it as well as a number of derivatives are described.

A Study of the Roles of Adrenocortical Steroids and Glomerular Filtration Rate in the Mechanism of the Diurnal Rhythm of Water and Electrolyte Excretion

“…The discovery of a sodium excreting mechanism or hormone, as yet unknown, could be useful in explaining these rhythms. Evidence that such a mechanism exists has been suggested here and by Leutscher & Curtis (1955) and Neher, Desaulles, Fischer, Wieland & Wettstein (1958). Should this be confirmed and found to be sufficiently powerful, one could postulate that the diurnal variation was due to its raised morning and daytime activity.…”

Impaired Aldosterone Production in “Salt-losing” Congenital Adrenal Hyperplasia*

“…Twenty-four hour urine collections were made Aldosterone secretion was determined by a modification 4Kindly provided by Dr. R. Gaunt, Ciba Pharmaceuticals, Summit, N. J. 5 New England Nuclear Corp., Boston, Mass.…”

“…An abnormal increase of aldosterone excretion in patients with the sodium-losing form of the syndrome suggested an action on the renal tubules of unknown steroids promoting sodium excretion (2). The hypersecretion of aldosterone was thought to be compensatory, and the sodium-losing compounds were sought among the steroids or degradation products of steroids appearing on the biosynthetic pathway before the site of the defect (5)(6)(7)(8). If such steroids are indeed responsible for the sodium loss, it follows that the sodium loss should disappear when abnormal steroid production is prevented by suppression of ACTH secretion.…”

Expedient synthesis of some novel pregnane derivatives and their evaluation as anti-oxidant and anti-dyslipidemic agents

“…The organic layer was washed with water, dried over anhydrous sodium sulphate and then concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel 3b-Hydroxy-16a, 17a-epoxypregn-5-en-20-one (15) Compound 1 was converted into compound 15 by reported method (Das and Kirk, 1984;Neher et al, 1958) …”