Isolation, Synthesis, and Antiplatelet Aggregation Activity of Resveratrol 3-O-β-d-Glucopyranoside and Related Compounds

Abstract

Resveratrol 3-O-beta-D-glucopyranoside (1) has been isolated from the seeds of Erythrophleum lasianthum (Caesalpinioidae, Leguminosae), a South African plant used in traditional medicine, and has shown antiplatelet aggregation activity. The synthesis of 1, related hydroxystilbenes, and their glucosides has been undertaken to provide larger quantities, for further biological evaluation, and has been accomplished via Wittig reactions followed by glucosylation under phase transfer catalysis.

Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes

“…A number of studies hypothesise that piceid may have biomedical properties similar to those above mentioned for resveratrol: anticarcinogenic effects [12,13] and inhibition of platelet aggregation [14,15] and of oxidation of LDL [16].…”

Glycosylation oftrans-Resveratrol by Plant-Cultured Cells

“…6,7) Several attempts have recently been made to synthesize resveratrol glycosides by chemical methods involving tedious protectiondeprotection procedures, and resulted in low yields. 8,9) Plant cell cultures would be useful for the practical preparation of glycosides, due to the high potential of plant glycosyltransferases to diastereoselectively produce glycosides by one-step enzymatic glycosylation.…”

Phytoestrogens in foods on the Nordic market

“…It is usually not known if the analysed samples have been healthy or had been stressed. Resveratrol has also been identified in many medicinal plants, such as Calligonum leucocladum (Okasaka et al, 2004), Cassia quinquangulata, C. garrettiana (Hata et al, 1979;Pezzuto, 2011), Erythropleum lasiantum (Orsini et al, 1997), Ficus barteri fruits (Ogungbamila et al, 1997), Reynoutria japonica (Kimura et al, 1995), Polygonum cuspidatum (Jayatilake et al, 1993;Vastano et al, 2000), and Smilax glabra (Chen et al, 1999). Paul et al (1999) demonstrated that darakshasava, an ayurvedic medicine from India, which main ingredient is Vitis vinifera, contains resveratrol and pterostilbene.…”