Isolation, structure elucidation and biological activity of metabolites from Sch-642305-producing endophytic fungus Phomopsis sp. CMU-LMA

Adelin, Emilie; Servy, Claudine; Cortial, Sylvie; Lévaique, Hélène; Martin, Marie‐Thérèse; Retailleau, Pascal; Goff, Géraldine Le; Bussaban, Boonsom; Lumyong, Saisamorn; Ouazzani, Jamal

doi:10.1016/j.phytochem.2011.08.010

Cited by 28 publications

(20 citation statements)

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“…CMU-LMA isolated from healthy wild galanga (Alpinia malaccensis) (Bussaban et al, 2005;Adelin et al, 2011b). We previously reported the bioconversion of Sch-642305 by Aspergillus ochraceus ATCC 1009 resting cells, which catalyzed the oxido-reductions of the six-membered ring (Adelin et al, 2011a).…”

Section: Resultsmentioning

confidence: 99%

Biotransformation of natural compounds: Unexpected thio conjugation of Sch-642305 with 3-mercaptolactate catalyzed by Aspergillus niger ATCC 16404 cells

et al. 2012

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Section: Resultsmentioning

confidence: 99%

Biotransformation of natural compounds: Unexpected thio conjugation of Sch-642305 with 3-mercaptolactate catalyzed by Aspergillus niger ATCC 16404 cells

et al. 2012

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“…CMU-LMA was isolated from Alpinia malaccensis. LMA-P1 exhibited the highest cytotoxic activity against the colonic epithelial cancer cell line HCT-116 cells with an IC 50 of 41 nM, benquoine and Sch-642305 had lower activity at 210 and 140 nM, respectively (Adelin et al 2011).…”

Section: Compounds From Endophytic Fungi Of Terrestrial Plantsmentioning

confidence: 96%

Fungal Endophytes: An Amazing and Hidden Source of Cytotoxic Compounds

Deshmukh

Verekar

2014

Microbial Diversity and Biotechnology in Food Security

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This review covers substantially the cytotoxic compounds isolated from endophytic fungi from terrestrial and mangrove plants during [2009][2010][2011][2012]. Endophytes living asymptomatically within plant tissues have been found in almost all plants studied to date. Many of the compounds reported here were originally isolated from plants, then from endophytic fungi, whereas some are exclusively isolated from endophytic fungi. The anticancer activities in this review are from the published cytotoxicity against specific cancer cell lines. Development of these natural compounds is based on their cytotoxic activity profiles, chemical structures, and potential structure-activity relationship deduced from the biochemical and cytotoxic studies.

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“…Compounds 103 and 104 with spirocyclic anhydride moiety represent a new structural type and inhibit the release of -glucuronidase from polymorphonuclear leukocyte [33]. Eight lactones (105-112, Scheme 7) were isolated from the endophytic fungus Phomopsis species CMU-LMA, and metabolite 106 exhibits a remarkable cytotoxicity against the colonic epithelial cancer cell line HCT-116 cells with an IC 50 value of 41 nmol/L [34]. Four cytotoxic macrolides including three new (113-115, Scheme 7) and roridin E (116, Scheme 7) were isolated from two Myrothecium roridum strains IFB-E009 and IFB-E012 [35].…”

Section: Esters and Lactonesmentioning

confidence: 99%