Symbionts, a promising source of bioactive natural products

Zhang, Xuan; Wei, Wei; Tan, Renxiang

doi:10.1007/s11426-015-5398-6

Cited by 30 publications

(16 citation statements)

References 92 publications

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“…This translates in symbiotic partnerships that are usually more dynamic in nature, contrasting many of the ancient nutritional symbioses 3 . There is a growing number of reports on bacteria with bioactive potential found in eukaryotic hosts 6 , 11 , 12 ; however, knowledge on the chemical basis of symbiont-mediated defense in the field is scarce 3 , 5 . Importantly, this in-depth knowledge is fundamental for understanding the ecological context and evolutionary dynamics of protective symbioses 13 – 16 .…”

Section: Introductionmentioning

confidence: 99%

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles

et al. 2018

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Microbial symbionts are often a source of chemical novelty and can contribute to host defense against antagonists. However, the ecological relevance of chemical mediators remains unclear for most systems. Lagria beetles live in symbiosis with multiple strains of Burkholderia bacteria that protect their offspring against pathogens. Here, we describe the antifungal polyketide lagriamide, and provide evidence supporting that it is produced by an uncultured symbiont, Burkholderia gladioli Lv-StB, which is dominant in field-collected Lagria villosa. Interestingly, lagriamide is structurally similar to bistramides, defensive compounds found in marine tunicates. We identify a gene cluster that is probably involved in lagriamide biosynthesis, provide evidence for horizontal acquisition of these genes, and show that the naturally occurring symbiont strains on the egg are protective in the soil environment. Our findings highlight the potential of microbial symbionts and horizontal gene transfer as influential sources of ecological innovation.

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Section: Introductionmentioning

confidence: 99%

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles

et al. 2018

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“…Due to co-evolution with their specific host, microbial symbionts express a variety of uniquely tailored biochemical traits, making them a highly productive source of secondary metabolites with well-defined architectures and medically and commercially attractive bioactivities [5]. As these compounds evolved to interact efficiently with a co-evolving biological target they are often structurally unique; indeed the Dictionary of Natural Products states that over 40% of these chemical scaffolds occupy a chemical space not represented by synthetic compounds [6].…”

Section: Introductionmentioning

confidence: 99%

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

et al. 2017

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Abstract:Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such diversity is mirrored in (or more likely increased by) the microbial symbionts associated with this group and in the marine natural products (or MNPs) that they produce. Since the early 1950s over 20,000 MNPs have been discovered, including compounds produced by symbiotic bacteria, and the chemical diversity of compounds produced from marine sources has led to them being referred to as "blue gold" in the search for new drugs. For example, 80% of novel antibiotics stemming from the marine environment have come from Actinomycetes, many of which can be found associated with marine sponges, and compounds with anti-tumorigenic and anti-diabetic potential have also been isolated from marine symbionts. In fact, it has been estimated that marine sources formed the basis of over 50% of FDA-approved drugs between 1981 and2002. In this review, we explore the diversity of marine microbial symbionts by examining their use as the producers of novel pharmaceutical actives, together with a discussion of the opportunities and constraints offered by "blue gold" drug discovery.

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“…Symbiosic microorganisms from insects, which are well-known as a rich source of bioactive natural products, have attracted widespread attention [ 1 – 3 ]. Especially, due to the special environmental conditions, the bioactive natural products from symbiotic microorganisms as a rich source of various compounds with complex structures and excellent activities, may reshape the experts’ views on the drug ability of natural products [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Setosphlides A–D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10

Gao

Wang

Chen

et al. 2021

Nat. Prod. Bioprospect.

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Investigation of the entomogenous fungus Setosphaeria rostrate LGWB-10 from Harmonia axyridis led to the isolation of four new isocoumarin derivatives, setosphlides A–D (1–4), and four known analogues (5–8). Their planar structures and the relative configurations were elucidated by comprehensive spectroscopic methods. The absolute configurations of isocoumarin nucleus for 1–4 were elucidated by their ECD spectra. The C-10 relative configurations for the pair of C-10 epimers (1 and 2) were established by comparing the magnitude of the computed 13C NMR chemical shifts (Δδcalcd.) with the experimental 13C NMR values (Δδexp.) for the epimers. All of the isolated compounds (1–8) were evaluated for their cytotoxicities against four human tumor cell lines MCF-7, MGC-803, HeLa, and Huh-7. Graphic Abstract

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Symbionts, a promising source of bioactive natural products

Cited by 30 publications

References 92 publications

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Setosphlides A–D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10

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