Isolation, Purification, Identification, Synthesis, and Kinetics of Activity of the Anticandidal Component ofAllium Sativum, and a Hypothesis for Its Mode of Action

Studies on the Anticandidal Mode of Action of Allium sativum (Garlic)

“…The mechanism of action of garlic is unknown, but Barone & Tansey (1977) proposed that garlic acts by inactivating essential thiols. Adetumbi et al (1986) proposed that blockage of lipid synthesis is likely to be an important feature of the anticandidal activity of garlic.…”

“…Investigations have been undertaken to provide a scientific basis for its medicinal use and several have reported its medicinal, insecticidal, antimicrobial, antiprotozoal and antitumour properties (Adetumbi et al, 1986;Moore & Atkins, 1977). In addition, garlic extract has been reported to possess an in vitro growth inhibition effect against a large number of fungi including yeasts (Appleton & Tansey, 1975;Barone & Tansey, 1977) and to have a protective effect against in vivo experimental fungal infections (Prasad et al, 1982). Kabelik (1970) demonstrated that garlic extract was more effective against pathogenic yeasts, especially Candida albicans, than nystatin, gentian violet or methylene blue.…”

Inhibition of Mycobacteria by Garlic Extract (Allium Sativum).

“…Aristotle and Hippocrates called attention to the healing powers of garlic, and Pasteur mentioned its medicinal and antibacterial properties (7). In addition to its well-documented antibacterial properties (11,12,15,19,20), garlic has also been found to be antifungal (2,5,6,13,14,16,18), antiprotozoal (3), and insecticidal (4).…”

Preliminary Report on Management of HIV/AIDS-Associated Opportunistic Skin Infections with PhytodermaTM, a Natural Myco-Based Cream

“…Although the disease burdens due skin infections are potentially high, they are hardly considered as major public health problems in literature and at the global health stage compared to malaria, tuberculosis and some neglected tropical diseases [1,[3][4][5] in Cameroon and most Sub Saharan Africa countries, skin infections due to fungi are increasingly competing on the scale with opportunistic infections associated with HIV/AIDS [1,[6][7] long term use of imidazole antifungal derivatives such as ketoconazole, fluconazole and econazole are becoming ineffective to treat many of the skin infections seen in these countries and these have been blamed largely on the unavailability of established antifungal gram guided prescription in health centers in these countries [8]. Similarly, other antifungal drugs such as griseofulvin, nystatin, diflucan, benzoic acids, and salicylic acid have also been over prescribed in sub Saharan Africa and over the years; leading to the development of resistant strains of many fungal species [9][10].…”

“…Infectious fungal skin diseases are increasing globally in patients with human immunodeficiency virus (HIV/AIDS) and even in those receiving antiretroviral therapy [1,2]. Although the disease burdens due skin infections are potentially high, they are hardly considered as major public health problems in literature and at the global health stage compared to malaria, tuberculosis and some neglected tropical diseases [1,[3][4][5] in Cameroon and most Sub Saharan Africa countries, skin infections due to fungi are increasingly competing on the scale with opportunistic infections associated with HIV/AIDS [1,[6][7] long term use of imidazole antifungal derivatives such as ketoconazole, fluconazole and econazole are becoming ineffective to treat many of the skin infections seen in these countries and these have been blamed largely on the unavailability of established antifungal gram guided prescription in health centers in these countries [8].…”