Inhibition of Mycobacteria by Garlic Extract (Allium Sativum).

Abstract

Thirty strains of mycobacteria, consisting of 17 species, were inhibited by various concentrations of garlic extract incorporated in Middlebrook 7H10 agar. The concentration required ranged from a low of 1.34 mg/ml to a high of 3.35 mg/ml of media. When there were multiple strains of a species, a mean inhibitory concentration was determined for that species. Six strains of Mycobacterium tuberculosis required a mean inhibitory concentration of 1.67 mg/ml of media.

Antimicrobial effects of Allium sativum L. (garlic), Allium ampeloprasum L. (elephant garlic), and Allium cepa L. (onion), garlic compounds and commercial garlic supplement products

“…The MIC values obtained for garlic clove homogenates against E. coli (7.5-15mg/mL) and S . uureus (7.5-15 mg/mL) were somewhat higher than those reported for six strains of Mycobacterium tuberculosis (1.34-3.35 mg/mL) (Delaha and Garagusi, 1985), while the MIC values against Cundidu albicuns (0.47-0.94 mg/mL) were similar to those reported by Ghannoum (1988) (0.8-1.6 mg/mL) for six clinical isolates. The MIC value for allicin against Cundidu ulbi- cum (7-10 pg/mL) is in agreement with that found by Yamada and Azuma (1977) (6.25pg/mL) for strain 381.…”

“…The antimicrobial (Adetumbi and Lau, 1983), cardiovascular (Lau, 1989;Kleijnen et ul., 1989), anticancer (Sumiyoshi and Wargovich, 1989), hypo-and hyperglycaemic, insecticidal and other beneficial properties of garlic (Fenwick and Hanky, 1985) have been the subject of a number of recent review articles. The antimicrobial effects of garlic have been extended to include 30 strains of mycobacteria consisting of 17 species (Delaha and Garagusi, 1985) and a number of medically important fungi (Appleton and Tansey, 1975;Barone and Tansey, 1977;Moore and Atkins, 1977;Fromthing and Bulmer, 1978).…”

Review of the Application of Garlic, Allium sativum, in Aquaculture

“…It appears that the in vitro studies of the inhibitory power of garlic extract against mycobacteria can be interpolated. It may be surmised that very high levels in serum would have to be achieved (Delaha and Garagusi 1985). These high levels could be toxic to the thiol groups of the animal or human being treated.…”

Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe

“…Although herbal medicines such as Chaulmoogra oil and its puri¢ed esters from Hydnocarpus species have long been used for the treatment of leprosy [4], and a few reports have shown anti-M. avium activity of a crude extract of Allium sativum [5,6], the role of chemically de¢ned substances from plants as antimycobacterial agents has not been established. In the present study, we investigated eight chemically de-¢ned natural substances from the tropical £ora in the Caribbean island of Guadeloupe as well as an essential oil fraction, and report on their activity against M. tuberculosis, M. avium and M. kansasii, which have recently emerged as major opportunistic infections among AIDS patients [1,2].…”