Isolation of Smooth Muscle Relaxing 1,3-Diarylpropan-2-ol Derivatives from<i>Acacia tortilis</i>

Hagos, Mekonen; Samuelsson, Gunnar; Kenne, Lennart; Modawi, B. M.

doi:10.1055/s-2006-962610

Cited by 16 publications

(9 citation statements)

References 2 publications

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“…So far, the presence of this compound originating from a plant source has been confirmed in one instance [16]. A few more reports exist on the presence of similar diarylpropane-2-ols of plant origin [17,18,19,20].…”

Section: Resultsmentioning

confidence: 91%

“…There are only a handful of reports documenting the presence of 1 or the presence of other structurally similar substances in plants. Rotundifolinol, quracol A and B, propterol I and II, and virolanols II are examples of compounds isolated from plant material possessing similar structures to 1 [16,17,18,19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Among them, (+) catechin has been shown to have an antispasmodic effect in rodents [21]. Moreover, Quracols A and B [18] are structurally similar to 1 and showed smooth muscle relaxation properties; also, phloroglucine is a commercial muscle relaxant in France. Based on these considerations, we evaluated 1 in a smooth muscle relaxing test.…”

Section: Introductionmentioning

confidence: 99%

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Isolation of 1-(3′,4′-Dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol from Grape Seed Extract and Evaluation of its Antioxidant and Antispasmodic Potential

Gleńsk

Hurst²,

Gliński³

et al. 2019

Molecules

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HPLC profiling of phenolics in grape seed extracts revealed a prominent peak of an unknown substance with concentrations up to 5.3%. Spectroscopic data allowed the identification of the compound 1 as 1-(3′,4′-dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol. 1 is known to be produced from catechin and epicatechin through anaerobic bacteria from human, as well as the rat, intestines. It was hypothesized that the marc remaining after expression of juice from grapes became infested during storage, resulting in the production of 1. Because compound 1 is infrequently found in nature and has never been found in grape seeds, its presence may be considered a marker of an unwanted anaerobic bacterial process occurring during production. The antioxidant potential of 1 was determined by DPPH, ABTS, and FRAP (ferric reducing antioxidant power) assays and compared to the potential of the following compounds: phloroglucine, pyrogallol, gallic acid, catechin, and epicatechin. Furthermore, it was established that 1 significantly reduced guinea pig ileum contraction induced by histamine.

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Section: Resultsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Isolation of 1-(3′,4′-Dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol from Grape Seed Extract and Evaluation of its Antioxidant and Antispasmodic Potential

Gleńsk

Hurst²,

Gliński³

et al. 2019

Molecules

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“…In India, this tree was introduced in 1958 from Israel [4]. Various extracts of this plant have the following actions like smooth muscle relaxing activity [5], effective in treatment of α 2 -adrenoceptor related diseases [6], antimicrobial activity against Bacillus subtilis , Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , and Candida albicans [7], in-vitro antiplasmodial and antileishmanial activity [8], antiviral effect against human immunodeficiency virus-1 [9], antiasthmatic [10], and hypotensive and diuretic property [11]. …”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity ofAcacia tortilis(Forsk.) Hayne ssp. raddiana Polysaccharide on Streptozotocin-Nicotinamide Induced Diabetic Rats

Bhateja¹,

Singh²

2014

BioMed Research International

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The present study was designed to investigate the antidiabetic activity of aqueous extract of Acacia tortilis polysaccharide (AEATP) from gum exudates and its role in comorbidities associated with diabetes in STZ-nicotinamide induced diabetic rats. Male albino Wistar rats were divided into control, diabetic control, glimepiride treated (10 mg/kg), and diabetic rats treated with 250, 500, and 1000 mg/kg dose of AEATP groups and fasting blood glucose, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, HDL, SGOT, and SGPT levels were measured. STZ significantly increased fasting blood glucose level, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels, whereas HDL level was reduced as compared to control group. After 7 days of administration, 500 and 1000 mg/kg dose of AEATP showed significant reduction (P < 0.05) in fasting blood glucose level compared to diabetic control. AEATP has also reduced total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels and improved HDL level as compared to diabetic control group. Our study is the first to report the normalization of fasting blood glucose level, lipid profile, and liver enzyme in AEATP treated diabetic rats. Thus, it can be concluded that AEATP may have potentials for the treatment of T2DM and its comorbidities.

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“…The leaves, bark, seeds, and a red gum have medicinal properties. In fact, two pharmacologically active compounds for treating asthma have been isolated from the bark (Hagos et al , 1987). The displacement of native plant species is therefore having a serious detrimental impact on rural communities, especially when one considers how many people depend on medicinal plants.…”

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confidence: 99%

Biofuels and invasive species from an African perspective – a review

Witt¹

2010

GCB Bioenergy

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A large number of proposed biofuel crops share the same traits as known invasive plant species, many of which are already present in Africa and include species such as Prosopis glandulosa Torrey (Mimosaceae), P. juliflora (Sw.) DC, Leucaena leucocephala (Lam.) de Wit (Mimosaceae), Azadirachta indica A. Juss. (Meliaceae), and others. In this paper, we mainly assess the impacts of invasive Prosopis species in Africa, particularly in Kenya and South Africa. Introduced Prosopis species have invaded over 4 million hectares in Africa, threatening crop and pasture production, reducing underground water reserves, and displacing native plant and animal species. This has major implications for millions of people who depend on natural resources for their survival. It is therefore suggested that known invasive or potentially invasive plant species not be introduced to countries or regions for biofuel production. If (after a stringent cost-benefit analysis) the introduction of a potentially invasive species is deemed critical for economic development and the benefits clearly outweigh the potential costs, countries should endeavour to abide by the Principles and Criteria for Sustainable Biofuel Production developed by the Roundtable on Sustainable Biofuels.

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Isolation of Smooth Muscle Relaxing 1,3-Diarylpropan-2-ol Derivatives fromAcacia tortilis

Cited by 16 publications

References 2 publications

Isolation of 1-(3′,4′-Dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol from Grape Seed Extract and Evaluation of its Antioxidant and Antispasmodic Potential

Isolation of 1-(3′,4′-Dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol from Grape Seed Extract and Evaluation of its Antioxidant and Antispasmodic Potential

Antidiabetic Activity ofAcacia tortilis(Forsk.) Hayne ssp. raddiana Polysaccharide on Streptozotocin-Nicotinamide Induced Diabetic Rats

Biofuels and invasive species from an African perspective – a review

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