ISOLATION OF SECONDARY METABOLITE COMPOUNDS FROM Elaeocarpus mastersii KING STEM BARK AND THEIR BIOLOGICAL ACTIVITY EVALUATION

Okselni, Tia; Santoni, Adlis; Efdi, Mai

doi:10.31788/rjc.2022.1525294

Cited by 3 publications

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“…Berdasarkan hasil pengukuran spektrum UV-Vis menunjukkan bahwa pita serapan maksimum (λ max ) pada panjang gelombang 224,80 nm. Pada panjang gelombang ini terjadi transisi elektron n-π* yang menunjukkan terbentuknya kromofor dari ikatan rangkap (C=O) 13 . Hal ini menunjukkan bahwa dari senyawa hasil isolasi tidak ada ikatan rangkap berkonjugasi.…”

Section: Uji Kemurnian Senyawa Dari Fraksi Heksana Tumbuhan Sirih Mer...unclassified

“…Pada bilangan gelombang 1456,26 tekuk CH 2 dan 1367,53 cm -1 menunjukkan adanya gugus geminal dimetil yang merupakan ciri khas dari senyawa triterpenoid. Kemudian pada bilangan ge-lombang 1240,23, 1192,01 cm -1 dan 1051,20 cm -1 menunjukkan adanya gugus C-O (alkohol) 13,15,16 . Perbedaan kekuatan aktivitas antibakteri disebabkan karena adanya perbedaan kandungan metabolit sekunder.…”

Section: Gambar 4 Spektrum Uv Senyawa Hasil Isolasiunclassified

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Isolasi Senyawa Metabolit Sekunder Dari Fraksi Aktif Antibakteri Pada Tumbuhan Sirih Merah (Piper porphyrophyllum)

Efdi,

M. Iqbal Alfarisyi,

Arifin

2022

J. Kim. Unand

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The red betel plant (Piper porphyrophyllum) belongs to the Piperaceae family which is traditionally used to treat various diseases, including headaches, bone pain, chest tightness, leprosy, stomach ache, as well as for various other diseases such as skin diseases and diabetes. In this study, the antibacterial activity was tested for the hexane, ethyl acetate and methanol extracts of red betel nut using the disc diffusion method and the isolation of secondary metabolites from the hexane fraction of red betel nut using column chromatography technique. Determination of the antibacterial activity of the three fractions showed that the methanol extract had better antibacterial activity compared to the hexane extract and ethyl acetate extract. UV spectrum analysis showed 3 bands with absorption of 282 nm in band I, 274.80 nm in band II and 224.80 nm in band III which means that they show characteristics for triterpenoid group compounds. FTIR analysis showed the presence of C-H, CH2, C=O, C-O alcohol and geminal dimethyl functional groups in the isolated compounds.

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Section: Uji Kemurnian Senyawa Dari Fraksi Heksana Tumbuhan Sirih Mer...unclassified

Section: Gambar 4 Spektrum Uv Senyawa Hasil Isolasiunclassified

Isolasi Senyawa Metabolit Sekunder Dari Fraksi Aktif Antibakteri Pada Tumbuhan Sirih Merah (Piper porphyrophyllum)

Efdi,

M. Iqbal Alfarisyi,

Arifin

2022

J. Kim. Unand

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“…This plant has high total phenolic contents [16,17]. Unfortunately, the literature studies showed that the isolated compounds of E. mastersii King were limited to the compounds of anthocyanins, cucurbitacins, ellagic acid derivatives, β-sitosterol, and βsitosterol glucoside [18][19][20]. Therefore, the aim of this study was to isolate the phenolic compounds of E. mastersii King leaves.…”

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Isolation, identification and α-glucosidase inhibition evaluation of a phenolic compound from Elaeocarpus mastersii King leaves

Okselni,

Efdi

2024

E3S Web Conf.

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Elaeocarpus mastersii King is an Indonesian folk medicine with high phenolic content. In this study, the E. mastersii King leaves were extracted using methanol solvent through maceration. The methanol extract was continuously fractionated by the liquid-liquid extraction using hexane, dichloromethane (DCM), and ethyl acetate solvents, respectively. The DCM fraction was purified by column chromatography using Silica gel 60 and Sephadex LH-20 as the stationary phase and monitored by thin-layer chromatography. This isolation process led to obtaining a pure compound with the appearance of white crystalline powder and a melting point of 198-199℃. This compound absorbed the UV light at the wavelength of 229 and 274 nm, as well as produced the bathochromic shift by the addition of NaOH reagent indicating the aromatic compound with the hydroxyl (OH) substituent. The IR spectrum confirmed the presence of aromatic and OH groups along with other functional groups, such as carbonyl (vmax 1693 cm-1) and alkane (C-H, vmax 2953 cm-1). The NMR data suggested the isolated compound as methyl gallate. Furthermore, the m/z value of the isolated compound was 185.04416 Da [M+H]+. It confirmed the monoisotopic mass of the methyl gallate (184.0362 Da). However, biological evaluation as an α-glucosidase inhibitor showed no positive activity.

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A flavonoid compound from Elaeocarpus mastersii king leaves and its activity evaluation as α-glucosidase inhibitor

Okselni,

Efdi

2023

Xvii Mexican Symposium on Medical Physics

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ISOLATION OF SECONDARY METABOLITE COMPOUNDS FROM Elaeocarpus mastersii KING STEM BARK AND THEIR BIOLOGICAL ACTIVITY EVALUATION

Cited by 3 publications

References 0 publications

Isolasi Senyawa Metabolit Sekunder Dari Fraksi Aktif Antibakteri Pada Tumbuhan Sirih Merah (Piper porphyrophyllum)

Isolasi Senyawa Metabolit Sekunder Dari Fraksi Aktif Antibakteri Pada Tumbuhan Sirih Merah (Piper porphyrophyllum)

Isolation, identification and α-glucosidase inhibition evaluation of a phenolic compound from Elaeocarpus mastersii King leaves

A flavonoid compound from Elaeocarpus mastersii king leaves and its activity evaluation as α-glucosidase inhibitor

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