Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

Ch, Chiu; Lh, Su; Chu, Chishih; Chia, JH; Wu, Ting; Lin, TY; Ys, Lee; Ou, JT

doi:10.1016/s0140-6736(04)16003-0

Cited by 69 publications

(57 citation statements)

References 56 publications

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“…In recent years, however, ceftriaxone-resistant Salmonella in humans as well as animals has frequently been reported worldwide, including reports from the United States, Europe, South America, Asia, and Russia (3,7,9,12,13,17,21,26,(32)(33)(34)(36)(37)(38). In Taiwan, a high percentage of Salmonella isolates have been resistant to ampicillin, chloramphenicol, tetracycline, and trimethoprim-sulfamethoxazole since the 1990s (18,22,31,40,41).…”

mentioning

confidence: 99%

“…(7,9,12,13,15,17,(36)(37)(38). This gene was first identified in a multiresistant S. enterica serovar Senftenberg strain isolated in 1994 (21).…”

mentioning

confidence: 99%

“…In Taiwan, this gene was first detected in Escherichia coli isolates collected in 1999 (39). Since then, it has been reported to be carried by various ceftriaxone-resistant Salmonella strains (9,37,38).…”

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confidence: 99%

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Ceftriaxone Resistance of Nontyphoidal Salmonella enterica Isolates in Northern Taiwan Attributable to Production of CTX-M-14 and CMY-2 β-Lactamases

Huang

Liu

et al. 2005

J Clin Microbiol

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. Sixteen of these isolates belonged to Salmonella serogroup B, nine belonged to serogroup C, four belonged to serogroup D, and two belonged to serogroup E. The majority were from stool cultures. The mechanism of resistance was investigated for eight isolates, including three S. enterica serovar Typhimurium, one S. enterica serovar Wagenia, one S. enterica serovar Senftenberg, one S. enterica serovar Derby, one S. enterica serovar Panama, and one S. enterica serovar Duesseldorf isolate. All eight patients from whom these isolates were recovered had community-acquired infections. All eight isolates were resistant to ampicillin, ceftriaxone, and cefotaxime but susceptible to imipenem and ciprofloxacin. Ceftriaxone resistance was due to the production of the CMY-2 AmpC ␤-lactamase by seven isolates and the CTX-M-14 ␤-lactamase by the remaining isolate. Both ␤-lactamase genes were carried on conjugative plasmids. In a 2.5-kb region encompassing the bla CMY-2 gene, at nucleotide 49 upstream of the start codon of bla CMY-2 , three of the seven bla CMY-2 -positive isolates had an A nucleotide and four had a G nucleotide. In conclusion, the ceftriaxone resistance of nontyphoidal Salmonella isolates in our hospital was attributed to the CTX-M-14 and CMY-2 ␤-lactamases.

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confidence: 99%

“…(7,9,12,13,15,17,(36)(37)(38). This gene was first identified in a multiresistant S. enterica serovar Senftenberg strain isolated in 1994 (21).…”

mentioning

confidence: 99%

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Ceftriaxone Resistance of Nontyphoidal Salmonella enterica Isolates in Northern Taiwan Attributable to Production of CTX-M-14 and CMY-2 β-Lactamases

Huang

Liu

et al. 2005

J Clin Microbiol

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“…Son yıllarda tüm dünyada Salmonella izolatlarındaki antimikrobiyal direnç oranlarının artığı bildirilmektedir (7,8). Ampisilin, kloramfenikol, trimetoprimsülfametoksazol gibi geleneksel birinci basamak ilaçların yanı sıra, seftriakson ve florokinolonlara da direnç bildirilmiştir (9)(10)(11)(12). Antibiyotik direncinin giderek artması, antibiyotik kullanımının gerekli olduğu durumlarda, ampirik tedavi seçenek-lerini etkilemesi bakımından oldukça önemlidir.…”

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Distribution and Antimicrobial Resistance of Salmonella Serovars Isolated in Kayseri Region

Gündoğdu¹,

Kılıç²,

Ulu-Kılıç³

et al. 2017

Klimik Dergisi

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Objective: In this study, serovar distributions and antimicrobial resistance profiles of Salmonella strains isolated from clinical samples of patients admitted to our hospital between 2013 and 2016 were evaluated. Methods: The identification and antimicrobial susceptibility profile of Salmonella isolates obtained from stool, blood, urine, abscess/wound cultures were retrospectively evaluated. The conventional methods, Phoenix 100 (Becton Dickinson Co., Sparks, Maryland, USA) automated system, and KirbyBauer disk diffusion methods were used for identification of the strains at species level and for the antibiotic susceptibility tests. The demographical and clinical features of the patients were obtained from patient files retrospectively. Results: A total of 75 Salmonella serovars were included in this study. The serovar distribution were 27 S. enteritidis, 25 S. typhi, 10 S. typhimurium, 6 S. paratyphi B, 1 S. choleraesuis, and 6 Salmonella spp. The ratio of S. enteritidis isolated from children is significantly higher, while S. typhi was mainly isolated from adults. The antibiotic resistance rates of Salmonella serovars were 55.7%, 7.6%, 7.6%, 6.3%, and 1.3% against ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, cefotaxime, and chloramphenicol respectively. The crude mortality rate was detected to be 6.7%. Conclusions: According to our study S. enteritidis and S. typhi were predominant serovars. In order to control the typhoid fever, preventive measures such as water and food hygiene, enhancement of sewage system are needed. High rate of antibiotic resistance in Salmonella serovars implies that the empirical treatment options will be affected in cases who require antibiotic use. Klimik Dergisi 2017; 30(1): 22-6.

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“…CMY-2 was first identified in a human clinical case of K. pneumoniae from Greece (4). Since then, CMY-2 has been identified in a large number of different human and animal Salmonella serovars (Newport [22], Typhimurium [1], Hadar [25], Senftenberg [12], Infantis [7,14], Agona [7], Ohio [1], Bredeney [1], Wien [2], Heidelberg [16], Mikawasima [17], Montevideo [17], Oranienburg [19], and Choleraesuis [8]) from humans and animals.…”

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confidence: 99%

Characterization of AmpC-Mediated Resistance in Clinical Salmonella Isolates Recovered from Humans during the Period 1992 to 2003 in England and Wales

Batchelor

Hopkins²,

Threlfall³

et al. 2005

J Clin Microbiol

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The increase in AmpC-mediated resistance in salmonellae constitutes a serious public health concern, since these enzymes confer resistance to a wide range of ␤-lactams. One hundred six isolates were selected from 278,308 Salmonella isolates based on resistance to ampicillin and cephalosporins and were subjected to further characterization. Nine isolates had a cefoxitin inhibition diameter <17 mm and were proven to be AmpC positive by multiplex PCR. Sequence analysis revealed the presence of bla DHA-1 , bla CMY-2 , and bla CMY-4 genes. All nine isolates presented different pulsed-field gel electrophoresis restriction profiles. The AmpC genetic determinants were present in transferable plasmids of around 11, 42, 70, 98, and 99 MDa. A combination of size and restriction fragment length polymorphism (RFLP) analysis showed that all the bla CMY plasmids investigated in our study were different, which suggests that bla CMY may be located in different plasmid environments. Some United Kingdom isolates linked to foreign travel showed RFLP plasmid patterns consistent with plasmids previously seen in the United States, which suggests that bla CMY-2 has also been disseminated through plasmid transfer. The fact that two of the domestically acquired United Kingdom isolates presented previously unseen RFLP plasmid patterns could indicate that these strains have followed routes different from those prevalent in North America or other parts of the world. This study represents the first report of bla CMY genes in Salmonella isolates in the United Kingdom and the first report of CMY-4 in Salmonella enterica serotype Senftenberg worldwide.Plasmid-mediated AmpC ␤-lactamases originate from the transfer of chromosomal genes onto plasmids. This transfer has resulted in plasmid-mediated AmpC enzymes in isolates of Escherichia coli, Klebsiella pneumoniae, Salmonella spp., Citrobacter freundii, Enterobacter aerogenes, and Proteus mirabilis. These plasmid-mediated ␤-lactamases have similar substrate profiles to the parental enzymes from which they appear to be derived, although the vast majority are noninducible. Several AmpC-type enzymes have been described including FOX, MOX, CMY, DHA, ACC, MIR, ACT, and LAT. Of particular interest in Salmonella are the CMY enzymes, especially CMY-2. There are currently 13 bla CMY genes identified, falling into two distinct groups based on DNA sequence homology. One group includes the genes CMY-2 to -7, LAT-1 to -4, and BIL-1 and originates from C. freundii (21), while the second group includes the genes for MOX-1 and -2, CMY-1, and CMY-8 to -11 and has an unknown origin (21). CMY-2 was first identified in a human clinical case of K. pneumoniae from Greece (4). Since then, CMY-2 has been identified in a large number of different human and animal Salmonella serovars (Newport [22] Most Salmonella infections result in moderate gastroenteritis, which resolves spontaneously. However, systemic infections, such as bacteremia and meningitis, may also develop and require antibiotic treatment. These invasive infec...

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Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

Cited by 69 publications

References 56 publications

Ceftriaxone Resistance of Nontyphoidal Salmonella enterica Isolates in Northern Taiwan Attributable to Production of CTX-M-14 and CMY-2 β-Lactamases

Ceftriaxone Resistance of Nontyphoidal Salmonella enterica Isolates in Northern Taiwan Attributable to Production of CTX-M-14 and CMY-2 β-Lactamases

Distribution and Antimicrobial Resistance of Salmonella Serovars Isolated in Kayseri Region

Characterization of AmpC-Mediated Resistance in Clinical Salmonella Isolates Recovered from Humans during the Period 1992 to 2003 in England and Wales

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