Distribution and Antimicrobial Resistance of Salmonella Serovars Isolated in Kayseri Region

Abstract

Objective: In this study, serovar distributions and antimicrobial resistance profiles of Salmonella strains isolated from clinical samples of patients admitted to our hospital between 2013 and 2016 were evaluated. Methods: The identification and antimicrobial susceptibility profile of Salmonella isolates obtained from stool, blood, urine, abscess/wound cultures were retrospectively evaluated. The conventional methods, Phoenix 100 (Becton Dickinson Co., Sparks, Maryland, USA) automated system, and KirbyBauer disk diffusion methods were used for identification of the strains at species level and for the antibiotic susceptibility tests. The demographical and clinical features of the patients were obtained from patient files retrospectively. Results: A total of 75 Salmonella serovars were included in this study. The serovar distribution were 27 S. enteritidis, 25 S. typhi, 10 S. typhimurium, 6 S. paratyphi B, 1 S. choleraesuis, and 6 Salmonella spp. The ratio of S. enteritidis isolated from children is significantly higher, while S. typhi was mainly isolated from adults. The antibiotic resistance rates of Salmonella serovars were 55.7%, 7.6%, 7.6%, 6.3%, and 1.3% against ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, cefotaxime, and chloramphenicol respectively. The crude mortality rate was detected to be 6.7%. Conclusions: According to our study S. enteritidis and S. typhi were predominant serovars. In order to control the typhoid fever, preventive measures such as water and food hygiene, enhancement of sewage system are needed. High rate of antibiotic resistance in Salmonella serovars implies that the empirical treatment options will be affected in cases who require antibiotic use. Klimik Dergisi 2017; 30(1): 22-6.