Isolation of New Rotenoids fromBoerhaavia diffusaand Evaluation of their Effect on Intestinal Motility

Abstract

A bioassay-guided separation of a methanolic extract obtained from the roots of Boerhaavia diffusa L. (Nyctaginaceae) allowed us to isolate five compounds belonging to the class of rotenoids: the known boeravinone D ( 1), boeravinone E ( 2), compound 5 and two novel compounds that we have named boeravinone G ( 3) and boeravinone H ( 4). The structures of the new molecules have been determined on the basis of their HR-EI-MS, (1)H- and (13)C-NMR and 2D-NMR (HMQC, HMBC) data. All the isolated rotenoids have been evaluated for their effect on intestinal motility in vitro. Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D.

Potent Antioxidant and Genoprotective Effects of Boeravinone G, a Rotenoid Isolated from Boerhaavia diffusa

“…1). The structures of these molecules were identified on the basis of the comparison of their spectral data with those reported in the literature [21], [22].…”

Oxygen species scavenger activities and phenolic contents of four West African plants

“…On the pharmacological level, they share anti-inflammatory properties (Mavar-Manga, Brkic, Marie, & Quetin-Leclercq, 2004). In addition, many scientific works report evidence of their effectiveness in antimicrobial (Agrawal, Srivastava, Srivastava, & Srivastava, 2004), antispasmodic (Borrelli et al, 2005), diuretic (Mishra & Singh, 1980), and immuno-modulating (Pandey, Maurya, Singh, Sathiamoorthy, & Naik, 2005) treatments. Our study, which is the first of its kind, aims at investigating the capacity of all four plants to scavenge reactive oxygen species (ROS) and at determining the compounds responsible for this effect.…”

Tracheal relaxation of five Ivorian anti-asthmatic plants: Role of epithelium and K+ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark

“…The effect of these plants on the muscle contractile tone has been little studied. The methanolic extract of Boerhavia diffusa roots was found to exhibit spasmolytic activity in the guinea pig ileum (Borrelli et al, 2005(Borrelli et al, , 2006 and anti-convulsant activity, which was also observed with its liriodendrin-rich fraction and possibly related to Ca 2+ channel inhibition (Kaur and Goel, 2011). A skeletal muscle-relaxant effect was also described ex vivo and in vivo for a Baphia nitida ethyl acetate extract (Adeyemi et al, 2006).…”