Isolation of long-chain esters from the rhizome of Polygonatum verticillatum by potent tyrosinase inhibition

Khan, Haroon; Saeed, Muhammad; Khan, Murad Ali; Izhar-Ul-Haq,; Muhammad, Naveed; Ghaffar, Rukhsana

doi:10.1007/s00044-012-0194-8

Cited by 13 publications

(8 citation statements)

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“…It has also been studied for antimalarial and antioxidant, metal accumulating, insecticidal, antibacterial, antipyretic, tracheorelaxant and antiinflammatory, antispasmodic and antidiarrheal, antinociceptive, aphrodisiac [199,235,[238][239][240][241][242]. Lipoxygenase, urease inhibition, anti tyrosinase activity of the aerial parts of the P. verticillatum was also observed which were attributed to the presence of saponins, alkaloids, flavonoids, phenols, tannins and terpenoids in considerable amount [243][244][245].…”

Section: Polygonatum Verticillatummentioning

confidence: 99%

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

Misra¹

2018

JONAM

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Astavarga is nature's most extravagant group of flowering plants found in Himalayan region. As the name Astavarga indicates, it contains eight medicinal plants belonging to Zingiberaceae, Orchidaceae and Liliaceae family viz, Kakoli, Kshirakakoli, Meda, Mahameda, Jeevak, Risbhaka, Riddhi and Vridddhi. As per Ayurveda this group of medicinal plants is classified as Rasayana (Rejuvenation) and is important constituents of preparations like Chyawanprasha rasayan, Ashtavarga churna, Brimhanigutika and Vajikaraghrita, etc. Astavarga plants are mostly used to treat sexual disorders, physical weakness, body pain, strengthen the immune system and as an overall tonic. The plants under this group have been the subject of limited biochemical phytochemical and biological activities investigations. Taking into consideration the therapeutic significance of Astavarga plants as described in the ancient Ayurvedic system of medicine, the detailed phytochemical and pharmacological studies appear imperative to scientifically validate the ancient claims. Thus, the present review article provides detailed information on the Ayurvedic uses, habit and habitats, botanical descriptions, chemical constituents and biological activities reported for this important group of plants. The chemical structures of the isolated compounds from these plants and their reported biological activities in the literature have also been included.The information provided in the present review may stimulate the researchers to explore their phytochemical and pharmacological properties which have not yet been attempted, comprehensively. It will generate the interest on "reverse pharmacology" approach to validate the knowledge that has been known from ancient times.

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Section: Polygonatum Verticillatummentioning

confidence: 99%

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

Misra¹

2018

JONAM

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“…These groups of compounds show different types of activities. Long chain esters from this plant exhibit potent tyrosinase inhibition [13], alkaloid, homoisolflavanone, triterpenoid and steroidal saponin show profound antimicrobial and anticancer properties [14-17] and emodin from Polygonatum has shown ameliorating effects on the memory consolidation [18]. Several compounds have also been isolated from the rhizomes of P. verticillatum including lectins [19], 5-hydroxymethyl-2-furaldehyde and diosgenin [8].…”

Section: Introductionmentioning

confidence: 99%

Studies on tracheorelaxant and anti-inflammatory activities of rhizomes of Polygonatum verticillatum

Khan

Saeed

Mehmood

et al. 2013

BMC Complement Altern Med

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BackgroundThe present study describes the tracheorelaxant and anti-inflammatory effects of Polygonatum verticillatum which may support its medicinal use in hyperactive airway complaints and inflammatory disorders.MethodsThe tracheorelaxant activity of crude extract of the rhizomes of P. verticillatum (PR) was assessed in isolated guinea-pig tracheal tissues immersed in tissue organ bath filled with Tyrode’s solution and a continuous supply of carbogen gas (95% O2 and 5% CO2). The contractile and relaxant responses of the tissue were measured using isometric transducers coupled with Power-Lab data acquisition system. The anti-inflammatory effect was evaluated in carrageenan-induced rat paw edema model, while the lipoxygenase inhibitory activity was performed in the in-vitro assay. Various chromatographic and spectroscopic techniques were used for the isolation and characterization of pure molecules.ResultsIn isolated guinea-pig tracheal preparations, PR caused complete inhibition of the high K+ (80 mM) and carbachol-induced contractions however, it was more potent against K+ than CCh, similar to verapamil. Pretreatment of the tissue with PR, displaced the Ca2+ concentration-response curves to the right, similar to that induced by verapamil, indicating the presence of Ca2+ channel blocking like activity. When tested on carrageenan-induced rat paw edema, PR demonstrated a marked reduction in edema with 65.22% protection at 200 mg/kg, similar to aspirin. In the in-vitro assay, PR showed lipoxygenase inhibitory activity (IC50: 102 ± 0.19 μg/mL), similar to baicalein. Bioactivity-guided fractionation led to the isolation of 2-hydroxybenzoic acid and β-sitosterol.ConclusionsThese results indicate that the plant possesses tracheorelaxant, mediated possibly through a Ca2+ channel blockade mechanism, and anti-inflammatory activities, which may explain the medicinal use of this plant in airway disorders and inflammation.

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“…More recently, we have scientifically strengthened the ethnobotanical uses of the plant in various established paradigms (Khan et al, 2010(Khan et al, , 2011a, antimalarial and antioxidant (Khan et al, 2012b), metal accumulation (Khan et al, 2012c;Saeed et al, 2010a), phytotoxicity (Saeed et al, 2010b), antipyretic (Khan et al, 2013a) bronchodilatory and antiinflammatory (Khan et al, 2013d), and enzyme inhibition (Khan et al, 2013c) activities. Phytochemically, long-chain esters with potent tyrosinase inhibition have been reported (Khan et al, 2013b).…”

Section: Introductionmentioning

confidence: 99%

Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of K⁺ channels

et al. 2013

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Polygonatum verticillatum has traditionally been used for various purposes. The present study was aimed to validate the antispasmodic and antidiarrheal properties of crude methanolic extract of rhizomes of P. verticillatum (PR). Isolated rabbit jejunum preparations were suspended in tissue baths to measure the isotonic responses using Power Lab data acquisition system for the antispasmodic activity of PR, while the antidiarrheal activity was conducted in vivo in mice. PR caused complete relaxation of the spontaneous contractions of isolated rabbit jejunum preparations in a dose-dependent mode. A complete inhibition was observed against low potassium (K þ ; 25 mM)-induced contractions, while the plant extract partially inhibited the high K þ (80 mM)-induced contractions. From a mechanistic point of view, the spasmolytic effect of PR against low K þ was antagonized by glibenclamide similar to the effect of cromakalim, thus showing the presence of constituents in PR mediating spasmolytic activity predominantly through the activation of adenosine triphosphate-sensitive K þ channels. When tested against castor oil-induced diarrhea in mice, oral administration of the plant extract manifested marked antidiarrheal activity at the doses of 500 and 1000 mg/kg similar to loperamide. This study provided a pharmacological basis for the medicinal use of PR in abdominal colic and diarrhea.

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Isolation of long-chain esters from the rhizome of Polygonatum verticillatum by potent tyrosinase inhibition

Cited by 13 publications

References 18 publications

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

Studies on tracheorelaxant and anti-inflammatory activities of rhizomes of Polygonatum verticillatum

Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of K⁺ channels

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Isolation of long-chain esters from the rhizome of Polygonatum verticillatum by potent tyrosinase inhibition

Cited by 13 publications

References 18 publications

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

Phytochemical, Botanical and Biological Paradigm of Astavarga Plants- The Ayurvedic Rejuvenators

Studies on tracheorelaxant and anti-inflammatory activities of rhizomes of Polygonatum verticillatum

Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of K+ channels

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Antispasmodic and antidiarrheal activities of rhizomes of Polygonatum verticillatum maneuvered predominately through activation of K⁺ channels