Isolation of hypotensive compounds from Solanum sisymbriifolium Lam.

Sub-chronic toxicity study of the methanol root extract ofCnestis ferruginea

“…Based on these facts, it has been said that pharmacological and toxicological evaluations of medicinal plants are essential for drug development (Ahmed et al, 2005;Ibarrola et al, 2000). Due to multiplicity of usage and tendency for prolonged use of the root decoction in traditional medicine, as aphrodisiac and for treatment of conditions like gynecological diseases, skin infections, urethral discharge, and sinusitis (Burkill, 1985), CF methanol root extract was investigated in this study for possible sub-chronic toxicity effects using a 90-day administration schedule at determined sub-therapeutic (80 mg/kg), therapeutic (400 mg/kg), and supra-therapeutic (1000 mg/kg) doses.…”

Antinociceptive activity of methanol extract of leaves of Solanum sisymbriifolium in heat and chemical-induced pain

“…(Solanaceae) is a densely prickly perennial herb commonly known as sticky nightshade. The plant is traditionally used in the treatment of stomachache, remitting fever, hysteria (Uddin, 2016), respiratory tract infections, central nervous system (CNS) disorders and diarrhea (Ibarrola et al, 2000;Ferro et al, 2005). This plant is also used as diuretic, antihypertensive (Gonzales Torrez, 1992), emenagogue and fertility regulator (Martinez-Crovetto, 1981).…”

“…This plant is also used as diuretic, antihypertensive (Gonzales Torrez, 1992), emenagogue and fertility regulator (Martinez-Crovetto, 1981). Pharmacological investigations of different parts of S. sisymbriifolium have reported hypotensive (Ibarrola et al, 2000), analgesic (Shilpi et al, 2005), neuropharmacological and antidiarrheal activity (Apu et al, 2013). Phytochemical analyses confirmed isolation of a number of pharmacologically active compounds from the plant including solamine, solasodiene and solasodine (Mazumdar, 1984), neolignan, designated as sisymbrifolin, and carpesterol together with β-sitosterol and its β-D-glucoside, cuscohygrine, (Evans and Somanabandhu, 1980;Ferro et al, 2005), solacaproine, solamargine, and β-solamarine (Ferro et al, 2005) and isonuatigenin-3-O-β-solatriose (Ibarrola et al, 2000).…”

“…Pharmacological investigations of different parts of S. sisymbriifolium have reported hypotensive (Ibarrola et al, 2000), analgesic (Shilpi et al, 2005), neuropharmacological and antidiarrheal activity (Apu et al, 2013). Phytochemical analyses confirmed isolation of a number of pharmacologically active compounds from the plant including solamine, solasodiene and solasodine (Mazumdar, 1984), neolignan, designated as sisymbrifolin, and carpesterol together with β-sitosterol and its β-D-glucoside, cuscohygrine, (Evans and Somanabandhu, 1980;Ferro et al, 2005), solacaproine, solamargine, and β-solamarine (Ferro et al, 2005) and isonuatigenin-3-O-β-solatriose (Ibarrola et al, 2000). Solasodine, a major alkaloid, isolated from the plant has demonstrated variety of biological activities including antifungal (Kusano et al, 1987), cytotoxic (Nakamura et al, 1996), hepatoprotective (Lin et al, 1988), antinociceptive (Basu and Lahiri, 1977;Pandurangan et al, 2010), anti-inflammatory (Pandurangan et al, 2011), anticonvulsant, CNS depressant (Chauhan et al, 2011) and antiatherosclerotic activity (Dixit et al, 1992).…”

Anti‐inflammatory effect of Solanum lycocarpum fruits

“…The dried white gum obtained from green fruits crushed in aqueous solution is commercialized under the name of 'polvilho-de-lobeira', and has been used for the treatment of diabetes and ulcers (Ortencio, 1994). The genus Solanum has anti-inflammatory (Lin et al, 1995), antihepatotoxic (Grace and Saleh, 1996) and hypotensive activities (Ibarrola et al, 2000), besides inhibiting allergic reactions and histamine release (Kim and Lee, 1998). Additionally, S. americanum Mill.…”