Sub-chronic toxicity study of the methanol root extract ofCnestis ferruginea

Ishola, Ismail O.; Akindele, Abidemi J.; Adeyemi, Olufunmilayo O.

doi:10.3109/13880209.2012.655376

Cited by 14 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some species such as Cnestis ferruginea is abundant in West Africa and in root applications, used in traditional medicine to treat diverse conditions were studied from subchronic toxicity in methanol root extract. The results showed that possible side effects identified as induced delayed platelet anomaly, anemia in females, weight reduction and sterility in males (Ishola et al, 2012).…”

Section: Screening Of Cytotoxic Activitymentioning

confidence: 91%

Bio-activities and phytochemical investigation of Cnestis palala (Lour.) Merr.

Dej-adisai¹,

Tinpun²,

Wattanapiromsakul³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Background: In traditional medicines, the root of Cnestis palala was used for the treatment of stomach ache, malaria, urinary track disorders and snakebite. The seed was used for poisoning rat and stray dogs. However, the bioactivities and chemical constituents have not been reported. So, this will be the first report. Results:The results showed that the ethanol leaf and bark extracts were active against S. aureus and S. epidermidis. The hexane leaf and seed extracts and petroleum ether bark and root extracts showed strongly inhibition values against MCF-7. Moreover, the petroleum ether bark extract exhibited high inhibition value against HT-29. Seven compounds were isolated as β-sitosterol-glucoside (CP1), hydroquinone (CP2), β-sitosterol (CP3), mixture of fatty acids (CP4) and ethyl caffeate (CP5), scopoletin (CP6) and 2-nonenal (CP7). The CP2 was strongly active against S. aureus and S. epidermidis, the MIC was showed 30.10 µg/ml and 15.05 µg/ml and the MBC was showed 15 µg/ml and 7.5 µg/ml, respectively. Conclusion: These results suggested that C. palala is a great potential source of anti-microbial agents. Hence, this is the first study, which will be the database for chemical constituents and bioactivities of C. palala.

show abstract

Section: Screening Of Cytotoxic Activitymentioning

confidence: 91%

Bio-activities and phytochemical investigation of Cnestis palala (Lour.) Merr.

Dej-adisai¹,

Tinpun²,

Wattanapiromsakul³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

show abstract

“…Decoctions from the plant root are also employed as an appetite stimulant, purgative, skin ointment, aphrodisiac, and as remedy for snake bite [122]. Oral administration of 80, 400, and 1000 mg/kg/day of the methanolic root extract of the plant to Wistar rats for 90 days resulted in profound weight loss, reductions in testicular weight loss and sperm count and testicular inflammation and necrosis, reduction in relative liver weight and hepatic steatosis, and interstitial nephritis [122]. Despite withdrawal of the extract from the rats for 30 days, these changes were irreversible [122].…”

Section: Cnestis Ferruginea (Cf) Vahl Ex DC (Connaraceae)mentioning

confidence: 99%

“…Its root decoctions are used to treat headache, migraine, toothache, dysmenorrhea, skin infections, gynecological troubles, dysentery, urethritis, and sinusitis [121]. Decoctions from the plant root are also employed as an appetite stimulant, purgative, skin ointment, aphrodisiac, and as remedy for snake bite [122]. Oral administration of 80, 400, and 1000 mg/kg/day of the methanolic root extract of the plant to Wistar rats for 90 days resulted in profound weight loss, reductions in testicular weight loss and sperm count and testicular inflammation and necrosis, reduction in relative liver weight and hepatic steatosis, and interstitial nephritis [122].…”

Section: Cnestis Ferruginea (Cf) Vahl Ex DC (Connaraceae)mentioning

confidence: 99%

Subchronic and Chronic Toxicities of African Medicinal Plants

Adeneye

2014

Toxicological Survey of African Medicinal Plants

View full text Add to dashboard Cite

“…The mice were further observed for up to 14 days following treatment for any signs of delayed toxicity and mortality. The median lethal dose (LD 50 ) was estimated according to the method described by Ishola et al [12].…”

Section: Acute Toxicitymentioning

confidence: 99%

Antidepressant, anxiolytic, and anticataleptic effects of aqueous leaf extract of Antiaris toxicaria Lesch. (Moraceae) in mice: possible mechanisms of actions

Agbaje

Ishola

Oniyire

2014

Journal of Basic and Clinical Physiology and Pharmacology

Self Cite

View full text Add to dashboard Cite

Background: The leaves of Antiaris toxicaria Lesch. (Moraceae) are used by traditional medicine practitioners in southwest Nigeria in the management of epilepsy, wounds, and neurological disorders. Hence, this study was undertaken to investigate the effect of the aqueous leaf extract of A. toxicaria on the central nervous system. Methods: One hour after administration of A. toxicaria [50-300 mg/kg orally (p.o.)], its antidepressant effect was evaluated using the forced swimming test (FST), anxiolytic effect using elevated plus maze (EPM) test, and anticataleptic effect using haloperidol-induced catalepsy, whereas its effects on hypnosis and motor coordination were studied using hexobarbitone-induced sleeping time and open-field tests, respectively, in mice. Results: Antiaris toxicaria (300 mg/kg) significantly increased swimming activity (36.88%) and reduced immobility time (38.54%). Pretreatment of mice with prazosin (an α1-adrenoceptor antagonist), sulpiride (a D2 receptor antagonist), and l-NG-nitro-arginine (nitric oxide synthase inhibitor) 15 min before A. toxicaria (300 mg/kg p.o.) treatment significantly prevented its antidepressant-like effect by 35.58%, 53.30%, and 56.11%, respectively, in the FST. However, pretreatment with metergoline (5-HT2 receptor antagonist), and atropine (muscarinic cholinergic antagonist) failed to reverse this effect. Interestingly, A. toxicaria (50 mg/kg) significantly increased open-arm exploration in the EPM by 70.31%, which was reversed by 82.66% in the presence of flumazenil [3 mg/kg intraperitoneally (i.p.)]. Haloperidol (1 mg/kg i.p.) induced cataleptic behavior in mice, which was reversed by A. toxicaria (300 mg/kg) (p<0.001) treatment. Conclusions: The results suggest that A. toxicaria possesses an antidepressant-like effect involving interaction with α1-adrenoceptor, D2 dopamine receptor, and nitrergic pathway; an anxiolytic-like effect linked to the benzodiazepine system; and a neuroprotective effect.

show abstract

Sub-chronic toxicity study of the methanol root extract ofCnestis ferruginea

Cited by 14 publications

References 15 publications

Bio-activities and phytochemical investigation of <i>Cnestis palala</i> (Lour.) Merr.

Bio-activities and phytochemical investigation of <i>Cnestis palala</i> (Lour.) Merr.

Subchronic and Chronic Toxicities of African Medicinal Plants

Antidepressant, anxiolytic, and anticataleptic effects of aqueous leaf extract of Antiaris toxicaria Lesch. (Moraceae) in mice: possible mechanisms of actions

Contact Info

Product

Resources

About