Isolation of Daphnetin-8-β-glucoside From Daphne Papyracea

Antimicrobial inhibitory activity of aqueous, hydroalcoholic and alcoholic extracts of leaves and stem of Daphne mucronata on growth of oral bacteria

“…Because of the increasing antibiotic resistance rates, manufacturing a new antimicrobial compound is a priority for researchers [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]. Since medicinal plants have fewer side effects and are less expensive, they can be used as a source of antibiotics.…”

“…The use of plants of the family Thymelaeaceae has a long history of treating diseases. The genus Daphne is the most medicinally imporant taxon and the most widely used [6], [7], [8], [9], [10]. The highest antimicrobial potentials were observed for the alcoholic extract of leaves.…”

“…This plant has been traditionally used to treat skin diseases and cancer. The daphnetin 8 glycoside obtained from D. mucronata might have cardiotoxic effects [7], [8], [9]. Cytotoxic activity of a hydroalcoholic extract of D. mucronata on different cells has been reported previously, mostly on lung cancer cells [10], [11], [12], [13].…”

Daphne l. Türlerinin kimyasal içeriği ve biyolojik aktiviteleri : chemical constituents and biological activities of daphne l. Species

“…Apigenol ve luteolol ile bunların bazı heterozitlerine D. sericea'nın topraküstü kısımlarında da rastlanmıştır (39). Bu bileşikler özet olarak Tablo 1'de (41,44,45). D. genkwa'dan umbelliferon, dafnoretin ve dafnozit gibi kumarinlerin izole edildiği kayıtlıdır (25,26).…”

Sulfate conjugation of daphnetin by the human cytosolic sulfotransferases

“…Daphnetin, 7,8-Dihydroxycoumarin, is a catecholic plant-derived compound which was first isolated from Daphne papyracea, a shrub belonging to the family Thymelaeaceae [Nasipuri and Ramstad, 1973]. As a biologically-active compound, daphnetin has been shown to exhibit multiple pharmacological effects, including analgesic [Jiang et al, 1984], anti-malarial [Yang et al, 1992], anti-inflammatory [Fylaktakidou et al, 2004], anticancer [Finn et al, 2004], anti-arthritic [Gao et al, 2008], and anti-pyretic [Du et al, 2014] activities.…”