Isolation of Coxsackievirus A24 variant from patients with hemorrhagic conjunctivitis in Cuba, 2008–2009

Fonseca, Magilé; Sarmiento, Luis; Resik, Sonia; Pereda, Niurka; Rodríguez, Hermis; Kourí, Vivian; Martínez, Pedro A.; Piñón, Alexander; Limonta, Daniel; Más, Pedro; Hung, Lai Heng

doi:10.1016/j.jcv.2011.10.006

Cited by 17 publications

(11 citation statements)

References 23 publications

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“…Acute hemorrhagic conjunctivitis (AHC) is a highly contagious, epidemic, eye disease that has been most commonly caused by an antigenic variant of CV-A24 (CV-A24v) over the past twenty years 13 34 35 . The VP1 sequences of Xinjiang CV-A24 strains were compared with those of other CV-A24 strains obtained from other provinces in China or from other counties.…”

Section: Resultsmentioning

confidence: 99%

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

Zhang¹,

Sun²,

Cui

et al. 2016

Sci Rep

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Poliomyelitis associated with circulating vaccine-derived polioviruses (cVDPVs) is a serious public health issue in the post-eradication era, and the occurrence of recombinant cVDPVs emphasizes the need to elucidate enterovirus C (EV-C) epidemiology. Stool samples were collected from 826 healthy children in Southern Xinjiang in 2011 to investigate EV-C circulation and epidemiology. Thirty-six EV-Cs were isolated and assigned to eight EV-C serotypes by molecular serotyping, suggesting the circulation of diverse EV-Cs in Xinjiang. Phylogenetic analysis showed that the Xinjiang EV-C strains had larger variation compared to the prototype and other modern strains. Additionally, the results showed unique characteristics of Xinjiang EV-Cs, such as the cytopathicity of CV-A1 strains to RD cells; the high divergence in CV-A11, CV-A13, CV-A17, and CV-A20 strains; the divergence of Xinjiang CV-A24 from AHC-related CV-A24 variant stains distributed worldwide; and the circulation of two novel EV-C serotypes (EV-C96 and EV-C99). Evaluations of this dense and diverse EV-C ecosystem will help elucidate the processes shaping enteroviral biodiversity. This study will improve our understanding of the evolution of enteroviruses and the recombination potential between polioviruses and other EV-Cs.

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Section: Resultsmentioning

confidence: 99%

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

Zhang¹,

Sun²,

Cui

et al. 2016

Sci Rep

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“…CA24v is a major etiological agent of AHC. After its first description in Singapore in 1970, AHC outbreaks caused by CA24v have occurred periodically throughout the world [2], [4], [8]–[11], [13]–[17]. According to previous studies, four genotypes of CA24v can be distinguished and identified by phylogenetic analysis of the 3Cpro and VP1 regions [18], [19].…”

Section: Discussionmentioning

confidence: 99%

Genetic Characteristics of the Coxsackievirus A24 Variant Causing Outbreaks of Acute Hemorrhagic Conjunctivitis in Jiangsu, China, 2010

et al. 2014

PLoS ONE

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During September 2010, an outbreak of acute hemorrhagic conjunctivitis reemerged in Jiangsu, three years after the nationwide epidemic in China in 2007. In total, 2409 cases were reported, 2118 of which were reported in September; 79.8% of those affected were students or teachers, with a median age of 16 years. To identify and demonstrate the genetic characteristics of the etiological agent, 52 conjunctival swabs were randomly collected from four different cities. After detection and isolation, 43 patients were positive for coxsackievirus A24 variant according to PCR and 20 according to culture isolation. Neither adenovirus nor EV70 was detected. A phylogenetic study of the complete 3Cpro and VP1 regions showed that the Jiangsu isolates clustered into a new lineage, GIV-C5, with two uniform amino-acid mutations that distinguished them from all previous strains. Another new cluster, GIV-C4, formed by Indian isolates from 2007 and Brazilian isolates from 2009, was also identified in this study. Interestingly, our isolates shared greatest homology with the GIV-C4 strains, not with the isolates that were responsible for the nationwide acute hemorrhagic conjunctivitis epidemic in China in 2007. Although all our isolates were closely related, they could be differentiated into two subclusters within GIV-C5. In conclusion, our study suggests that a new cluster of coxsackievirus A24 variant that had already evolved into diverse strains was associated with the acute hemorrhagic conjunctivitis outbreaks in Jiangsu in September 2010. These viruses might have originated from the virus isolated in India in 2007, rather than from the epidemic strains isolated in China in 2007.

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“…Epidemics were first described in Ghana in 1969 [12], and CV-A24v was first isolated during an epidemic in Singapore in 1970 [13]. In the past four decades, CV-A24v was recognised as the major pathogen responsible for acute haemorrhagic conjunctivitis epidemics [14][15][16] and has recently been responsible for outbreaks in Brazil, China, Cuba, Sudan and Uganda [17][18][19][20]. Human-to-human direct transmission is usually through lachrymal secretions or respiratory contamination [21].…”

Section: Discussionmentioning

confidence: 99%

2012 outbreak of acute haemorrhagic conjunctivitis in Indian Ocean Islands: identification of Coxsackievirus A24 in a returned traveller

et al. 2012

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In May 2012, a Coxsackievirus A24 haemorrhagic conjunctivitis was diagnosed in Marseille, France, in a traveller returning from the Comoros Islands. This case allowed identification of the cause of an ongoing outbreak of haemorrhagic conjunctivitis in Indian Ocean Islands, illustrating that returning travellers may serve as sentinels for infectious diseases outbreaks in tropical areas where laboratory investigation is limited.

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Isolation of Coxsackievirus A24 variant from patients with hemorrhagic conjunctivitis in Cuba, 2008–2009

Cited by 17 publications

References 23 publications

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

Genetic Characteristics of the Coxsackievirus A24 Variant Causing Outbreaks of Acute Hemorrhagic Conjunctivitis in Jiangsu, China, 2010

2012 outbreak of acute haemorrhagic conjunctivitis in Indian Ocean Islands: identification of Coxsackievirus A24 in a returned traveller

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