Isolation of Commisterone, a new phytoecdysone fromCyanotis vaga

Santos, Alfredo C.; Chua, Modesto Tan; Eufemio, N.; Abela, C.

doi:10.1007/bf02112664

Cited by 7 publications

(2 citation statements)

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“…Medium to high values were obtained with species from the genera Cyanotis and Palisota, which had already been reported to contain ecdysteroids (Chua et al, 1982;Kusamba et al, 1995;Santos et al, 1970Santos et al, , 1972Tan et al, 2001Tan et al, , 2002aTan et al, ,b, 2003aTan et al, ,b, 2005. In a few genera (e.g., Aneilema, Commelina), values were generally low to very low, but one species was shown to contain high or very high concentrations (Table 3).…”

Section: Analysis Of Other Species In the Commelinaceaementioning

confidence: 84%

“…Our preliminary investigation of other Commelinaceae species has resulted in the identification of several ecdysteroid-rich species and not only in the previously investigated Cyanotis (Santos et al, 1970;Tan, 2002), Palisota (Kusamba et al, 1995), and Murdannia (Hou et al, 1980) genera. Several new ecdysteroid-rich species have been identified that deserve further investigation.…”

Section: Discussionmentioning

confidence: 96%

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Ecdysteroids from Cyanotis longifolia Benth. (Commelinaceae)

Crouzet¹,

Maria²,

Dinan³

et al. 2009

Arch Insect Biochem Physiol

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Cyanotis longifolia Benth. (Commelinaceae) contains ecdysteroids, which are highly concentrated in the roots and flowers, whereas leaves contain only very low amounts and stems intermediate amounts. 20-Hydroxyecdysone is the major component found in all tissues, but roots also contain large amounts of 20-hydroxyecdysone 3-acetate and ajugasterone C. A preparative experiment has shown that roots contain a complex ecdysteroid mixture, and the analysis of minor components has allowed the isolation of several already known ecdysteroids (polypodine B, 2-deoxy-20,26-dihydroxyecdysone, isovitexirone, poststerone) together with five new (ajugasterone C 3-acetate, 5beta-hydroxy-poststerone, poststerone 2-acetate, 14(15)-dehydro-poststerone 2-acetate, 24-epi-atrotosterone A [=24-methyl-ajugasterone C]) ecdysteroids that have been fully characterized. A preliminary investigation of 55 species belonging to 15 different genera of the Commelinaceae has shown that several of them contain significant concentrations of ecdysteroids, among which some previously uninvestigated ones appear to be very promising sources of ecdysteroids.

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Section: Analysis Of Other Species In the Commelinaceaementioning

confidence: 84%

Section: Discussionmentioning

confidence: 96%

Ecdysteroids from Cyanotis longifolia Benth. (Commelinaceae)

Crouzet¹,

Maria²,

Dinan³

et al. 2009

Arch Insect Biochem Physiol

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Innovative and Future Applications for Ecdysteroids

Lafont

Dinan

Ecdysone: Structures and Functions

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We review the current and potential importance and applications of ecdysteroids in the areas of agriculture, medicine and ecotoxicology. Since ecdysteroids are not only the steroid hormones of arthropods (and probably other invertbrate groups), but also have significant pharmaceutical effects on vertebrates, man's use of ecdysteroid agonists and antagonists (steroidal or non-steroidal) could potentially have considerable impact upon human health and the environment. The challenge is to maximise the benefits, while minimising the potential negative impacts. As agrochemicals, ecdysteroids themselves have little potential as exogenous pest control agents, but the many analogues are highly useful for determining the structural and spatial requirements for binding to nuclear and taste receptors and elevation of phytoecdysteroid levels in selected plant species could provide an environmentally benign approach to protect crop species against phytophagous predators (insects and nematodes). We briefly summarise the many attributed positive pharmaceutical effects of ecdysteroids in vertebrates (especially humans) and critically assess the reports associating ecdysteroids with cancer and embryotoxicity and the probable use of ecdysteroids as doping substances for athletes. We stress the need for much more extensive research into the metabolism and mode of action of ecdysteroids particularly in mammals. The presence of natural and, increasingly, man-made ecdysteroid agonists and antagonists may have considerable impact on the environment. On the one hand, non-steroidal (ant)agonists offer considerable promise as environmentally friendlier, more selective pesticides, but, on the other hand, could become endocrine disruptors of non-target species, especially in aquatic ecosystems. We consider in some depth the development of strategies for the identification and environmental monitoring of potential endocrine disruptors affecting ecdysteroid hormonal systems in invertebrates and emphasise the overwhelming need for basic research into the endocrinology of aquatic invertebrates which would be suitable as signal species.R. Lafont ( ) and L. Dinan

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Ecdysones of Plant Origin

Hara¹,

Takemoto²

1974

Invertebrate Endocrinology and Hormonal Heterophylly

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Isolation of Commisterone, a new phytoecdysone fromCyanotis vaga

Cited by 7 publications

References 0 publications

Ecdysteroids from Cyanotis longifolia Benth. (Commelinaceae)

Ecdysteroids from Cyanotis longifolia Benth. (Commelinaceae)

Innovative and Future Applications for Ecdysteroids

Ecdysones of Plant Origin

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