Isolation of Boswelliains A—E, Cembrane‐Type Diterpenoids from Boswellia papyifera, and an Evaluation of Their Wound Healing Properties

Abstract

Main observation and conclusion Boswelliains A—E (1—5), five new cembrane‐type diterpenoids, were isolated from the resin of Boswellia papyifera. Their structures, determined by using spectroscopic, computational and chemical methods, demonstrate that 2—5 are novel 4,5‐seco‐, 4,5‐seco‐, 9,10‐seco‐, and 6,7‐seco‐cembrane diterpenoids, and that 1, 4 and 5 bear aldehyde moieties. An evaluation of the wound healing properties of these natural products along with a derivative of 2 shows that compounds 2 and 3 significantly stimulate proliferation, mobility and tuber formation of human umbilical vein endothelial cells (HUVECs) at the concentration of 20 μmol/L.

Racemic Norlignans as Diastereoisomers from Ferula sinkiangensis Resins with Antitumor and Wound-Healing Promotion Activities

“…Previous research has shown that norlignans possessed an anti-tumor potential [19,20]. Inspired by the traditional medicinal applications of F. sinkiangensis, antitumor and wound-healing activities of compounds 1a/1b-4a/4b by using cell proliferation and cell migration assays in TNBC cells and HUVECs were evaluated [17,26].…”

“…Plant resins have become our research interest in recent years. As a result, several structure intriguing compounds have been described by us from resins with different sources [15][16][17]. Considering the medicinal importance of F. sinkiangensis resins, an investigation of the EtOAc extracts of this material was initiated and four new norlignans that Plant resins have become our research interest in recent years.…”

“…Considering the medicinal importance of F. sinkiangensis resins, an investigation of the EtOAc extracts of this material was initiated and four new norlignans that Plant resins have become our research interest in recent years. As a result, several structure intriguing compounds have been described by us from resins with different sources [15][16][17]. Considering the medicinal importance of F. sinkiangensis resins, an investigation of the EtOAc extracts of this material was initiated and four new norlignans that possess tetrahydrofuran rings were isolated.…”

Uncommon Capnosane Diterpenes with Neuroprotective Potential from South China Sea Soft Coral Sarcophyton boettgeri

“…Initiated by the 1,14-cyclisation of a GGPP precursor, the following bond formations of cembrane lead to a range of polycyclic diterpenes with diverse scaffolds, including 1,2-cyclized casbanes [ 10 ], 2,11-cyclized eunicellins [ 11 ], 3,7-cyclized capnosanes [ 12 , 13 ], and 2,20-cyclized sarsolenanes [ 12 , 13 ], as well as the newly discovered carbocyclic skeletons [ 14 , 15 ]. Additionally, the bond cleavages of cembrane afford an array of norcembranoids [ 16 , 17 ] and seco-cembranes [ 18 , 19 ]. These derivatives might originate from various types of enzymatic and/or non-enzymatic reactions, such as the Diels–Alder reaction, Michael addition, Pinacol rearrangement, Baeyer–Villiger oxidation, etc.…”

Sesquiterpenoid-Chromone Heterohybrids from Agarwood of Aquilaria sinensis as Potent Specific Smad3 Phosphorylation Inhibitors

“…Our interest in recent years is focusing on the characterization of natural products from plant resins. As a result, structurally intriguing compounds with important biological properties have been isolated from various resins such as those of Commiphora , Boswellia , and Populus euphratica. − In the course of our systematic studies on plant resins, 15 kg of the title material was investigated, resulting in the isolation of two heterodimers, aquilarines A ( 1) and B ( 2 ), consisting of a sesquiterpenoid and a chromone or chromone-like moiety (Figure ). In particular, compound 1 is characteristic of a pyridine core that bridges the sesquiterpenoidal and chromone-like blocks.…”