Isolation of Asian Virus from Extrapulmonary Tissues in Fatal Human Influenza.,

Kaji, Masahide; Oseasohn, Robert; Jordan, William S.; Dingle, John H.

doi:10.3181/00379727-100-24597

Cited by 45 publications

(21 citation statements)

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“…Kaji et al (3) have provided evidence of extrarespiratory infection by isolating a small amount of virus in autopsies from three influenza-related deaths. Others have demonstrated that virus could be recovered from the blood during the early asymptomatic but not the symptomatic stage (4,5).…”

Section: Discussionmentioning

confidence: 99%

Detection of Influenza Virus Rna in Peripheral Blood Mononuclear Cells of Influenza Patients

Tsuruoka

Kuroda

et al. 1997

JJMSB

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SUMMARY:Gastroenteritis, arthralgaia and myalgia are frequently associated with influenza virus infections in humans.One explanation for these symptoms may be extrarespiratory transmission of virus by peripheral blood mononuclear cells (PBMC). We tried to detect genomic viral RNA of the nucleoprotein (NP) and H3 subtype hemagglutinin (HA) genes by the method of RT-PCR in PBMC of 18 children aged 1-14 who sufferred from an influenza outbreak in the Kansai district of Japan between December 1992 and February 1993 . Three of the 18 samples were RT-PCR positive.The NP gene sequence observed in one patient's PBMC was identical to that obtained from his throat swab fluid. The HA gene sequences observed in the two other PBMC differed from those of RT-PCR-amplified DNA from throat swabs by an order of 3-9 nucleotides.We believe these results suggest the presence of a PBMC-associated virus.

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Section: Discussionmentioning

confidence: 99%

Detection of Influenza Virus Rna in Peripheral Blood Mononuclear Cells of Influenza Patients

Tsuruoka

Kuroda

et al. 1997

JJMSB

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“…Secondly, the use of protease inhibitors has been shown to effectively block the development of generalized infection. Such a treatment could be effective against complications (7, 8, t0, 11, 29, 41, 47) which can arise due to the spread of virus throughout the organism (11,14,18,25,31,37,49). Undoubtedly, further investigations are required so that protease inhibitors with optimal therapeutic action, and which lack toxic side-effects can be selected for the treatment, of influenza in humans.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of protease inhibitors in influenza virus infected animals

Жирнов

Овчаренко

Bukrinskaya

1982

Archives of Virology

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“…Several older studies have documented cardiac changes associated with acute influenza virus infection in 15%-43% of ambulatory patients and in 14%-75% of hospitalized patients [6][7][8]. Influenza virus infection has been associated with 1%-18% of myocarditis cases [9][10][11][12][13][14][15][16][17][18][19][20][21].…”

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confidence: 99%