Isolation of an inhibitor of hepatic cholesterolgenesis from human milk

Ward, Priscilla; McCarthy, Rose; Kilara, Arun

doi:10.1016/0021-9150(82)90184-8

Cited by 15 publications

(5 citation statements)

References 29 publications

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“…While these publications did not explain the inverse association with cholesterol, it is possible that the cachexia of cancer, which is associated with reduced fat stores and muscle wasting, releases glutamate and glutamine that can increase SUA levels, and indeed elevated SUA has been associated with sarcopenia [27]. On the other hand, in vitro analysis of liver tissue slices demonstrated that UA itself inhibited cholesterol biosynthesis upstream of mevalonic acid, possibly by inhibition of hydroxymethylglutaryl CoA reductase [28], suggesting a potentially broad effect of UA on cholesterol level.…”

Section: Reviewmentioning

confidence: 99%

Contribution of uric acid to cancer risk, recurrence, and mortality

Fini

Elias²,

Johnson

et al. 2012

Clinical & Translational Med

174

166

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Two risk factors for the development and progression of cancers that are amenable to life style modification are chronic inflammation and the metabolic syndrome. This review proposes two new targets that may mechanistically integrate inflammation and metabolic syndrome, have been largely ignored, and are known to be druggable. Recent evidence has demonstrated that elevated serum uric acid (hyperuricemia) is associated with excess cancer risk, recurrence, and mortality. Although uric acid (UA) can function as a systemic antioxidant, its pro‐inflammatory properties have been postulated to play an important role in the pathogenesis of cancer. Furthermore, obesity, Type 2 Diabetes Mellitus (T2DM), and the metabolic syndrome (MetS) are also associated with excess cancer, chronic inflammation, and with hyperuricemia, suggesting that UA may represent an important link between these disorders and the development of cancer. While pharmacological modulation of hyperuricemia could in principal augment anti‐cancer therapeutic strategies, some cancer cells express low intracellular levels of the enzyme Xanthine Oxidoreductase (XOR) that are associated with increased cancer aggressiveness and poor clinical outcome. Thus, systemic pharmacological inhibition of XOR may worsen clinical outcome, and specific strategies that target serum uric acid (SUA) without inhibiting tumor cell XOR may create new therapeutic opportunities for cancer associated with hyperuricemia. This review will summarize the evidence that elevated SUA may be a true risk factor for cancer incidence and mortality, and mechanisms by which UA may contribute to cancer pathogenesis will be discussed in the hope that these will identify new opportunities for cancer management.

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Section: Reviewmentioning

confidence: 99%

Contribution of uric acid to cancer risk, recurrence, and mortality

Fini

Elias²,

Johnson

et al. 2012

Clinical & Translational Med

174

166

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“…Although uric acid has been reported to inhibit hepatic cholesterolgenesis in vitro (Ward et al, 1982), no studies have been done on its hypocholesterolemic effects when fed orally. Since high uric acid levels cause gout, such investigations are not likely to be done in humans, who cannot further metabolize uric acid.…”

Section: Yogurt Compositionmentioning

confidence: 99%

“…Recent evidence suggests that I three organic acids are likely hypocholesterolemic agents. Hydroxymethylglutaric (HMG) and erotic acids lower serum cholesterol when fed to rats (Beg and Siddiqi, 1968;Bernstein et al, 1977) and humans (Robinson and Dombrowski, 1983), while uric acid has been identified as a cholesterol synthesis inhibitor from human milk (Ward et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

Effect of Consuming Yogurts Prepared with Three Culture Strains on Human Serum Lipoproteins

Jaspers

Massey

Luedecke

1984

Journal of Food Science

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Ten human adult males' usual diets were modified by incorporating 681g nonfat, unpasteurized yogurt daily throughout three 1421 day periods. A different set of select culture strains, two commercial and one patented, were used for yogurt production in the three dietary periods. Including yogurt daily in the diet significantly reduced fasting total serum cholesterol l&12% in human adult males on some days, but serum cholesterol returned towards control values with continued yogurt consumption. Serum triglycerides and the proportions of serum lipoproteins were not significantly influenced by increasing yogurt consumption. Differences in concentrations of uric, erotic and hydroxymethylglutaric-like acids in the yogurts were insufficient to account for the differences in temporary hypocholesterolemic effects of yogurt consumption seen between strains.

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“…Quantitative determinations of these acids in dairy products is important not only for flavor studies and as an indicator of bacterial activity, but also for nutritional reasons. The main one is their association with lowering of serum cholesterol (Mann, 1977;Ward et al, 1982;Ahmed et al, 1979;Papa et al, 1982).…”

mentioning

confidence: 99%

Effects of Fermentation and Storage on the Concentration of Orotic Acid and Uric Acid in Skim Milk

Navder

Huang

Fryer

et al. 1990

Journal of Food Science

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Skim milk (SM) and skim milk yogurt (SMY) were produced and analyzed using high performance liquid chromatography (HPLC) for the presence of two organic acids-erotic acid (OA) and uric acid (VA). The concentration of OA in SM and SMY at 0 days was 106.2 and 46.1 ppm, respectively. After fermentation OA concentration was 56% lower (P <0.05) in SMY than in nonfermented SM. UA content of SM and SMY at 0 days was 23.3 and 20.1 ppm, respectively. Unlike OA, the UA contents were not significantly altered after fermentation. No significant differences were detected in the concentrations of OA and UA when values of Sm and SMY of 0 days were compared with those after 3 days storage.

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Isolation of an inhibitor of hepatic cholesterolgenesis from human milk

Cited by 15 publications

References 29 publications

Contribution of uric acid to cancer risk, recurrence, and mortality

Contribution of uric acid to cancer risk, recurrence, and mortality

Effect of Consuming Yogurts Prepared with Three Culture Strains on Human Serum Lipoproteins

Effects of Fermentation and Storage on the Concentration of Orotic Acid and Uric Acid in Skim Milk

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