Effect of Consuming Yogurts Prepared with Three Culture Strains on Human Serum Lipoproteins

Abstract

Ten human adult males' usual diets were modified by incorporating 681g nonfat, unpasteurized yogurt daily throughout three 1421 day periods. A different set of select culture strains, two commercial and one patented, were used for yogurt production in the three dietary periods. Including yogurt daily in the diet significantly reduced fasting total serum cholesterol l&12% in human adult males on some days, but serum cholesterol returned towards control values with continued yogurt consumption. Serum triglycerides and the proportions of serum lipoproteins were not significantly influenced by increasing yogurt consumption. Differences in concentrations of uric, erotic and hydroxymethylglutaric-like acids in the yogurts were insufficient to account for the differences in temporary hypocholesterolemic effects of yogurt consumption seen between strains.

Genetic and Proteomic Analysis of Factors Affecting Serum Cholesterol Reduction by Lactobacillus acidophilus A4

“…It has been reported that probiotic bacteria and dairy products can modulate serum cholesterol levels in many animal models of induced hypercholesterolemia (8,19,39), but the mechanism responsible for this phenomenon is still not clear. The aim of these in vivo experiments was to establish that the microbial molecular factors identified in the in vitro experiments would affect serum cholesterol in vivo.…”

Some Beneficial Effects of Probiotic Bacteria

“…Rao et al (41) reported that metabolites from orotic acid formed during fermentation of fermented dairy products may help lower cholesterol level. According to Jaspers et al (19), uric acid inhibits cholesterol synthesis and orotic acid and hydroxymethylglutanic acid reduce serum cholesterol.…”

Effects ofLactobacillus acidophilus43121 and a Mixture ofLactobacillus caseiandBifidobacterium longumon the Serum Cholesterol Level and Fecal Sterol Excretion in Hypercholesterolemia-Induced Pigs

“…6) Fermented dairy products such as yogurt have been reported to have hypocholesterolemic effects in humans and rats. [7][8][9] The possible hypocholesterolemic effect of lactic acid bacteria may be mediated by: i) enhanced bile acid excretion into feces by bile acid deconjugation; 10) ii) enhanced bile acid excretion into feces by bile acid assimilation; 11,12) or iii) enhanced dietary cholesterol excretion into feces by direct cholesterol assimilation. 11,13,14) Enhanced bile acid excretion would result in a decrease in quantity of bile acids returning to the liver, resulting in reduced feedback inhibition of bile acid synthesis and increased conversion of cholesterol to bile acids.…”