Isolation of an alkaloid from Vinca minor*

Scheindlin, Stanley; Rubin, Nathan

doi:10.1002/jps.3030440605

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…The first isolation of a Vinca alkaloid was made by Lucas in 1859, and since then the research continued along the centuries [26]. In the early 1900 s, Vinca species were still insufficiently studied, and three new alkaloids were described for V. minor and three for V. herbacea [27][28][29]. Later, 43 alkaloids were isolated from V. major, 40 from V. minor and three from V. herbacea.…”

Section: Introductionmentioning

confidence: 99%

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The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

et al. 2021

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The phytochemical analysis of Vinca minor, V. herbacea, V. major, and V. major var. variegata leaf extracts showed species-dependent antioxidant, antibacterial, and cytotoxic effects correlated with the identified phytoconstituents. Vincamine was present in V. minor, V. major, and V. major var. variegata, while V. minor had the richest alkaloid content, followed by V. herbacea. V. major var. variegata was richest in flavonoids and the highest total phenolic content was found in V. herbacea which also had elevated levels of rutin. Consequently, V. herbacea had the highest antioxidant activity followed by V. major var. variegata. Whereas, the lowest one was of V. major. The V. minor extract showed the most efficient inhibitory effect against both Staphylococcus aureus and E. coli. On the other hand, V. herbacea had a good anti-bacterial potential only against S. aureus, which was most affected at morphological levels, as indicated by scanning electron microscopy. The Vinca extracts acted in a dose-depended manner against HaCaT keratinocytes and A375 melanoma cells and moreover, with effects on the ultrastructure, nitric oxide concentration, and lactate dehydrogenase release. Therefore, the Vinca species could be exploited further for the development of alternative treatments in bacterial infections or as anticancer adjuvants.

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Section: Introductionmentioning

confidence: 99%

“…Later, 43 alkaloids were isolated from V. major, 40 from V. minor and three from V. herbacea. After 2010 and up until now, new alkaloids are discovered and isolated almost every year only for V. minor, nine new alkaloids were described and isolated from V. major and two from V. herbacea [19,20,27,30,31].…”

Section: Introductionmentioning

confidence: 99%

The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

et al. 2021

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“…The technique using 133Xe for the measure ment of the regional cerebral blood flow (rCBF), makes it possible to solve some of these problems; this method is used here for studying the cerebral hemodynamic effects of Vinc amine, a synthetic alkaloid of Vinca minor (,Scheindlin, 1955\Kuehne, 1964.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Vincamine on the Regional Cerebral Blood Flow in Man

Depresseux¹

1978

Eur Neurol

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The cerebral hemodynamic action of Vincamine is measured in 17 patients with primary or secondary cerebral circulation disorders, by use of the multiregional ¹³³Xe clearance technique. The statistical analysis of the results justifies the grouping of all the cases and the distinction between reference, ischemic and hyperemic zones by determining for each subject a range of + or –15% of his own mean regional cerebral blood flow. The drug, in a single injection in the internal carotid artery, shows a significant beneficial hemodynamic effect on the ischemic regions of the brain. No steal phenomenon is recorded in the middle cerebral artery territory. The action of the drug leads to a decrease and an equalization of the hemodynamic resistances of the cerebral vascular bed.

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Studies on the hypoglycemic effect of ‘Vincamin’

Káldor¹,

Szabó²

1960

Experientia

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Isolation of an alkaloid from Vinca minor*

Cited by 11 publications

References 8 publications

The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

The Effect of Vincamine on the Regional Cerebral Blood Flow in Man

Studies on the hypoglycemic effect of ‘Vincamin’

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